Atropine Sulfate Injection

Riik: Austraalia

keel: inglise

Allikas: Department of Health (Therapeutic Goods Administration)

Toimeaine:

Atropine sulfate

Saadav alates:

Pfizer Australia Pty Ltd

Klass:

Medicine Registered

Infovoldik

ATROPINE SULFATE INJECTION BP
1
ATROPINE SULFATE
INJECTION BP
_Atropine sulfate_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions people ask about
Atropine Sulfate Injection BP.  It
does not contain all the information
that is known about atropine sulfate.
IT DOES NOT TAKE THE PLACE OF TALKING
TO YOUR DOCTOR OR PHARMACIST.
All medicines have risks and
benefits.  Your doctor will have
weighed the risks of you taking
Atropine Sulfate Injection BP against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT ATROPINE SULFATE
INJECTION BP  IS FOR
Atropine Sulfate Injection BP is most
commonly used to reduce body
secretions such as saliva, during
surgery.
Atropine Sulfate Injection BP can
also be used as an antidote for certain
types of poisons.  It is also
sometimes used because of its actions
on the heart.
After surgery, it is used to reverse the
effects of medicines given to you to
stop your muscles moving during the
operation.
Atropine Sulfate Injection BP works
by stopping some of the actions of a
naturally occurring substance called
acetylcholine.
Your doctor will have explained why
you are being treated with Atropine
Sulfate Injection BP.
FOLLOW ALL DIRECTIONS GIVEN TO YOU
BY YOUR DOCTOR CAREFULLY.
They may differ from the
information contained in this leaflet.
Your doctor may prescribe this
medicine for another use.  Ask your
doctor if you want more information.
Atropine sulfate is not addictive.
BEFORE YOU ARE GIVEN
ATROPINE SULFATE
INJECTION BP
You may already have been given
Atropine Sulfate Injection BP.  Your
doctor will have considered the
situation carefully and decided to use
it.  However, if any of the following
applies to you, tell your doctor
immediately.
_WHEN YOU MUST N

Toote omadused

Atropine Sulfate Injection BP Product Information
1 (11)
ATROPINE SULFATE INJECTION BP
PRODUCT INFORMATION
NAME OF THE DRUG
Atropine sulfate is
bis[(1_R_,3_r_,5_S_)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2_RS_)-3-
hydroxy-2-phenylpropanoate] sulphate monohydrate.
The Australian Approved Name is atropine sulfate.
The CAS Registry Number for atropine sulfate is 5908-99-6.
The chemical structure for atropine sulphate is:
DESCRIPTION
Atropine, a naturally occurring belladonna alkaloid, is a racemic
mixture of equal
parts of d- and l-hyoscyamine, whose activity is due almost entirely
to the laevo
isomer of the drug.  Atropine sulfate is a white crystalline powder
or colourless
crystals, very soluble in water, freely soluble in alcohol and
practically insoluble in
ether.  Empirical formula (C
17
H
23
NO
3 
)
2
, H
2
SO
4
, H
2
O.  MW 694.8
The injection is a clear, colourless, sterile solution containing
atropine sulfate and
sodium chloride in Water for Injections BP, adjusted to pH 2.8 - 4.5
with hydrochloric
acid.  Atropine sulfate injection contains no antimicrobial agent.
 It should be used
only once in one patient only, and any residue discarded.
PHARMACOLOGY
Atropine is often classified as an anticholinergic drug but is more
accurately
described as an antimuscarinic agent since it inhibits the muscarinic
actions of
acetylcholine, possessing both central and peripheral activity.
Atropine has activity both on structures innervated by postganglionic
cholinergic
nerves, and on smooth muscles which respond to endogenous
acetylcholine but are
not so innervated.  As with other antimuscarinic agents, the major
action of atropine
is a competitive or surmountable antagonism which can be overcome by
increasing
the concentration of acetylcholine at receptor sites of the effector
organ (e.g. by using
anticholinesterase agents which inhibit the enzymatic destruction of
acetylcholine).
The receptors antagonised by atropine in therapeutic doses are
primarily the
peripheral structures that are stimulated or inhi