ATROPINE SULFATE- atropine sulfate injection, solution

Riik: Ameerika Ühendriigid

keel: inglise

Allikas: NLM (National Library of Medicine)

Toimeaine:

ATROPINE SULFATE (UNII: 03J5ZE7KA5) (ATROPINE - UNII:7C0697DR9I)

Saadav alates:

Cardinal Health

Manustamisviis:

INTRAVENOUS

Retsepti tüüp:

PRESCRIPTION DRUG

Näidustused:

Atropine Sulfate Injection, USP is indicated (1) as an antisialogogue for preanesthetic medication to prevent or reduce secretions of the respiratory tract, (2) to restore cardiac rate and arterial pressure during anesthesia when vagal stimulation produced by intra-abdominal surgical traction causes a sudden decrease in pulse rate and cardiac action, (3) to lessen the degree of atrioventricular (A-V) heart block when increased vagal tone is a major factor in the conduction defect as in some cases due to digitalis, (4) to overcome severe bradycardia and syncope due to a hyperactive carotid sinus reflex, (5) as an antidote (with external cardiac massage) for cardiovascular collapse from the injudicious use of a choline ester (cholinergic) drug, (6) in the treatment of anticholinesterase poisoning from organophosphorus insecticides, and (7) as an antidote for the “rapid” type of mushroom poisoning due to the presence of the alkaloid, muscarine, in certain species of fungus such as Amanita muscaria . Atropine ge

Toote kokkuvõte:

Atropine Sulfate Injection, USP is supplied in single-dose containers as follows: List No. Needle Size    Conc. Total Content (Atropine)   LifeShield ® Abboject Unit of Use Syringe with male luer lock adapter and protected needle 4910 20-G              5 mL 0.1 mg/mL (Adult)              0.5 mg 4911 20-G            10 mL 0.1 mg/mL (Adult)              1 mg Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]   Revised: February, 2007   Printed in USA                                            EN-1435 Hospira, Inc., Lake Forest, IL 60045 USA Cardinal Health Zanesville, OH 43701 IA60031111

Volitamisolek:

unapproved drug other

Toote omadused

ATROPINE SULFATE- ATROPINE SULFATE INJECTION, SOLUTION
CARDINAL HEALTH
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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ATROPINE SULFATE
Injection, USP
0.1 MG/ML
LIFESHIELD
ABBOJECT UNIT OF USE SYRINGE
R only
DESCRIPTION
Atropine Sulfate Injection, USP is a sterile, nonpyrogenic isotonic
solution of atropine sulfate
monohydrate in water for injection with sodium chloride sufficient to
render the solution isotonic. It is
administered parenterally by subcutaneous, intramuscular or
intravenous injection.
Each milliliter (mL) contains atropine sulfate, monohydrate 0.1 mg
(adult strength) and sodium chloride,
9 mg. May contain sodium hydroxide and/or sulfuric acid for pH
adjustment 0.308 mOsmol/mL (calc.).
pH 4.2 (3.0 to 6.5).
The solution contains no bacteriostat, antimicrobial agent or added
buffer (except for pH adjustment) and
is intended for use only as a single-dose injection. When smaller
doses are required the unused portion
should be discarded.
Atropine Sulfate Injection is a parenteral anticholinergic agent and
muscarinic antagonist.
Atropine Sulfate, USP is chemically designated 1α H, 5α
H-Tropan-3-α ol (±)-tropate (ester), sulfate
(2:1) (salt) monohydrate, (C
H NO ) • H SO • H O, colorless crystals or white crystalline
powder
very soluble in water.
It has the following structural formula:
Atropine, a naturally occurring belladonna alkaloid, is a racemic
mixture of equal parts of d- and 1-
hyocyamine, whose activity is due almost entirely to the levo isomer
of the drug.
®
x
17
23
3 2
2
4
2
Sodium Chloride, USP is chemically designated NaCl, a white
crystalline powder freely soluble in
water.
CLINICAL PHARMACOLOGY
Atropine is commonly classified as an anticholinergic or
antiparasympathetic (parasympatholytic) drug.
More precisely, however, it is termed an antimuscarinic agent since it
antagonizes the muscarine-like
actions of acetyl-choline and other cho