Riik: Austraalia
keel: inglise
Allikas: Department of Health (Therapeutic Goods Administration)
hydrochlorothiazide,valsartan
Apotex Pty Ltd
Hydrochlorothiazide,Valsartan
Registered
APO-VALSARTAN HCTZ TABLETS _Contains the active ingredients valsartan and hydrochlorothiazide_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about valsartan HCTZ. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is APO- Valsartan HCTZ. It contains the active ingredients valsartan and hydrochlorothiazide. It is used to treat hypertension (high blood pressure). High blood pressure increases the workload of the heart and blood vessels. If it continues for a long time, it can damage the blood vessels in the brain, heart and kidneys. This can lead to stroke, heart failure or kidney failure. High blood pressure increases the risk of heart attacks. Lowering your blood pressure reduces the chance of these disorders happening. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Valsartan HCTZ reduces blood pressure in two different ways. 1. Vals Lugege kogu dokumenti
Product Information APO-VALSARTAN HCTZ TABLETS Page 1 APO-VALSARTAN HCTZ 80/12.5, 160/12.5, 160/25, 320/12.5, 320/25 TABLETS NAME OF THE MEDICINE Valsartan and hydrochlorothiazide. VALSARTAN Chemical Name: (2_S_)-3-Methyl-2-[pentanoyl[[2′-(1_H_-tetrazol-5-yl)biphenyl-4- yl]methyl]amino]butanoic acid Structural Formula: Molecular Formula: C 24 H 29 N 5 O 3 Molecular Weight: 435.5 CAS Registry Number: 137862-53-4 HYDROCHLOROTHIAZIDE Chemical Name: 6-Chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide] Structural Formula: Molecular Formula: C 7 H 8 ClN 3 O 4 S 2 Molecular Weight: 297.7 CAS Registry Number: 58-93-5 DESCRIPTION Valsartan is a white or almost white, hygroscopic powder. It is practically insoluble in water, freely soluble in anhydrous ethanol, sparingly soluble in methylene chloride, soluble in methanol, neutral and basic aqueous solution, and very slightly soluble in solutions with pH < 7. Hydrochlorothiazide (HCTZ) is structurally related to the thiazide group of diuretics. It is a white or almost white crystalline powder. Hydrochlorothazide is very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent) and freely soluble in dimethylsulfoxide. It dissolves in dilute solutions of alkali hydroxides. pKa: Valsartan: Carboxylic acid group: 3.9 & Tetrazole group: 4.7; Hydrochlorothiazide: 7.9, 9.2 Partition Coefficient: Valsartan (n-octanol/aq phosphate buffer): 0.033; LogP for Hydrochlorothiazide: - 0.07 Product Information APO-VALSARTAN HCTZ TABLETS Page 2 Each tablet contains the following amount of valsartan and hydrochlorothiazide respectively: 80/12.5mg, 160/12.5mg, 160/25mg, 320/12.5mg and 320/25mg. In addition, each tablet contains the following inactive ingredients: powdered cellulose, calcium hydrogen phosphate, colloidal anhydrous silica, croscarmellose sodium, magnesium stearate, hypromellose, hydroxypropyl cellulose, titanium dioxide, iron oxide red (80/12.5mg, 160/12.5mg, 160/25mg & 320/12.5mg), iron oxide black (160/25mg & 320/12.5mg Lugege kogu dokumenti