Amlodipine Pfizer

Riik: Austraalia

keel: inglise

Allikas: Department of Health (Therapeutic Goods Administration)

Toimeaine:

Amlodipine

Saadav alates:

Pfizer Australia Pty Ltd

Klass:

Medicine Registered

Infovoldik

AMLODIPINE PFIZER

_amlodipine (am-load-i-peen) besylate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about AMLODIPINE
PFIZER.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking
AMLODIPINE PFIZER against the
benefits it is expected to have for
you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT AMLODIPINE
PFIZER IS USED FOR
_WHAT IT DOES_
AMLODIPINE PFIZER is used to
•
lower high blood pressure
(hypertension).
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems.
•
treat angina pectoris.
Angina is a pain or uncomfortable
feeling in the chest, often spreading
to the arms or neck, and sometimes
to the shoulders and back. The pain
of angina is due to a shortage of
oxygen to the heart.
AMLODIPINE PFIZER is not for
the relief of a sudden attack of
angina. Your doctor will give you
other medication to treat this.
_HOW IT WORKS_
AMLODIPINE PFIZER belongs to a
group of medicines called calcium
channel blockers or calcium ion
antagonists. They work by widening
your blood vessels, making it easier
for your heart to pump blood around
the body and help increase the supply
of blood and oxygen to your heart.
Calcium channel blockers do not
change the amount of calcium in
your blood or bones.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY
AMLODIPINE PFIZER HAS BEEN
PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
This medicine is available only with
a doctor's prescription.
_USE IN CHILDREN_
There is not enough information to
recommend the use of this medicine
in children.
BEFORE YOU TAKE

Toote omadused

 
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PRODUCT INFORMATION

AMLODIPINE PFIZER (AMLODIPINE BESYLATE) 
NAME OF THE MEDICINE 
AMLODIPINE PFIZER amlodipine (as besylate) 5 mg and
10 mg tablets. 
AMLODIPINE PFIZER contains
the active ingredient amlodipine besylate.  Amlodipine 
besylate is a dihydropyridine derivative and has
the following structural formula: 
N
Cl
H
3
CO
2
C
H
3
C
H
CH
2
OCH
2
CH
2
NH
2
CO
2
CH
2
CH
3
SO
3
H

Chemical name: 
3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-
dihydro-6-methyl-3,5-pyridinedicarboxylate benzene sulphonate 
Molecular formula: 
C
20
H
25
ClN
2
O
5.
C
6
H
6
O
3
S 
Molecular weight: 
567.1 (free base 408.9) 
CAS registry numbers:  amlodipine 88150-42-9; amlodipine besylate 111470-99-6. 
DESCRIPTION 
Amlodipine  besylate  is  a  white  crystalline  powder,  and  is  slightly  soluble  in  water  and 
sparingly soluble in ethanol. 
In  addition  to  amlodipine  besylate,  each  AMLODIPINE  PFIZER  tablet  contains  the 
following  inactive  ingredients:  microcrystalline  cellulose;  calcium  hydrogen  phosphate; 
sodium starch glycollate; magnesium stearate. 
PHARMACOLOGY 
PHARMACODYNAMICS 
Amlodipine is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) 
and  inhibits  the  transmembrane  influx  of  calcium  ions  into  cardiac  and  vascular  smooth 
muscle. 
Experimental  data  suggest  that  amlodipine  binds  to  both  dihydropyridine  and 
nondihydropyridine binding sites.  The contractile processes of cardiac muscle and vascular 
smooth  muscle  are  dependent  upon  the  movement  of  extracellular  calcium  ions  into  these 

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cells  through  specific  ion  channels.    Amlodipine