País: Sudáfrica
Idioma: inglés
Fuente: South African Health Products Regulatory Authority (SAHPRA)
Zoetis South Africa (Pty) Ltd
See ingredients
TABLET
EACH CHEWABLE TABLET CONTAINS CARPROFEN 100,0 mg
Registered
2004-12-10
Zoetis South Africa (Pty) Ltd RIMADYL CHEWABLE 25 Carprofen 25 mg per chewable tablet 2.1 VMRF1 – Part 1C Date of amendment: 15 November 2016 RIMADYL ® CHEWABLE 25 RIMADYL ® CHEWABLE 75 RIMADYL ® CHEWABLE 100 Chewable Tablets VETERINARY MEDICINE SCHEDULING STATUS: Schedule 3 PROPRIETARY NAMES (AND DOSAGE FORMS): RIMADYL CHEWABLE 25 chewable tablets RIMADYL CHEWABLE 75 chewable tablets RIMADYL CHEWABLE 100 chewable tablets COMPOSITION: RIMADYL CHEWABLE 25: Each tablet contains 25 mg Carprofen RIMADYL CHEWABLE 75: Each tablet contains 75 mg Carprofen RIMADYL CHEWABLE 100: Each tablet contains 100 mg Carprofen PHARMACOLOGICAL CLASSIFICATION: C 3.1.2.2 NSAIDs, Selective COX2 inhibitors PHARMACOLOGICAL ACTION: Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity. The exact mode of action of carprofen has not been established; however, inhibition of prostaglandin synthesis accounts for at least part of its mechanism of action. Carprofen is a moderately potent inhibitor of phospholipase A 2 and a reversible inhibitor of cyclo-oxygenase (COX). In _ in-vitro _ cell-culture of canine origin, carprofen displayed selectivity for COX-2, the inducible form of the enzyme upregulated in damaged and inflamed tissue, compared with its inhibition of COX-1, the iso-enzyme which is involved in normal gastric function. Carprofen has also been shown to inhibit the release of prostaglandins in acute polymorphonuclear leukocytes and chronic inflammatory reactions. Zoetis South Africa (Pty) Ltd RIMADYL CHEWABLE 25 Carprofen 25 mg per chewable tablet 2.1 VMRF1 – Part 1C Date of amendment: 15 November 2016 Carprofen has modulatory effects on both humoral and cellular immune responses. It inhibits the production of osteoclast-activating factor (OAF), PGE 1 and PGE 2 by its inhibitory effects on prostaglandin biosynthesis. Following repeat therapeutic dosing for eight weeks, carprofen has shown to have no detrimental effect on canine arthritic cartilag e . In addition Leer el documento completo