País: Estados Unidos
Idioma: inglés
Fuente: NLM (National Library of Medicine)
CARPROFEN (UNII: FFL0D546HO) (CARPROFEN - UNII:FFL0D546HO)
Elanco US Inc.
ORAL
PRESCRIPTION
quellin is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. quellin should not be used in dogs exhibiting previous hypersensitivity to carprofen.
quellin soft chewable tablets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 30 or 120 tablets.
Abbreviated New Animal Drug Application
QUELLIN- CARPROFEN TABLET, CHEWABLE ELANCO US INC. ---------- QUELLIN (carprofen) soft chewable tablets Non-steroidal anti-inflammatory drug FOR ORAL USE IN DOGS ONLY CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: quellin (carprofen) is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen and ketoprofen. Carprofen is the nonproprietary designation for a substituted carbazole, 6-chloro-α-methyl-9H-carbazole- 2-acetic acid. The empirical formula is C H ClNO and the molecular weight 273.72. The chemical structure of carprofen is: Carprofen is a white, crystalline compound. It is freely soluble in ethanol, but practically insoluble in water at 25°C. CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models. The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in 15 12 2 1 2 inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. In an _in vitro_ study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Clinical relevance of these data has not been shown. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition of acute (PMN sy Leer el documento completo