País: Estados Unidos
Idioma: inglés
Fuente: NLM (National Library of Medicine)
PAPAVERINE HYDROCHLORIDE (UNII: 23473EC6BQ) (PAPAVERINE - UNII:DAA13NKG2Q)
American Regent, Inc.
PAPAVERINE HYDROCHLORIDE
PAPAVERINE HYDROCHLORIDE 30 mg in 1 mL
INTRAVENOUS
PRESCRIPTION DRUG
Papaverine is recommended in various conditions accompanied by spasm of smooth muscle, such as vascular spasm associated with acute myocardial infarction (coronary occlusion), angina pectoris, peripheral and pulmonary embolism, peripheral vascular disease in which there is a vasospastic element, or certain cerebral angiospastic states; and visceral spasm, as in ureteral, biliary, or gastrointestinal colic. Intravenous injection of papaverine is contraindicated in the presence of complete atrioventricular heart block. When conduction is depressed, the drug may produce transient ectopic rhythms of ventricular origin, either premature beats or paroxysmal tachycardia. Papaverine Hydrochloride is not indicated for the treatment of impotence by intracorporeal injection. The intracorporeal injection of papaverine hydrochloride has been reported to have resulted in persistent priapism requiring medical and surgical intervention. Drug dependence resulting from the abuse of many of the selective depressants, includin
Papaverine Hydrochloride Injection, USP, 30 mg/mL 0517-4002-25 2 mL Vial packaged in boxes of 25 0517-4010-01 10 mL Multiple Dose Vial* packaged individually *The 10 mL Multiple Dose Vial contains chlorobutanol 0.5% as a preservative. Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) (See USP Controlled Room Temperature). PROTECT FROM LIGHT. RETAIN IN CARTON UNTIL TIME OF USE. AMERICAN REGENT, INC. SHIRLEY, NY 11967 IN4002 Rev. 1/09
unapproved drug other
PAPAVERINE HYDROCHLORIDE- PAPAVERINE HYDROCHLORIDE INJECTION, SOLUTION AMERICAN REGENT, INC. _Disclaimer: This drug has not been found by FDA to be safe and effective, and this_ _labeling has not been approved by FDA. For further information about unapproved_ _drugs, click here._ ---------- PAPAVERINE HYDROCHLORIDE INJECTION, USP RX ONLY This product is to be used by or under the direction of a physician. Each vial contains a sufficient amount to permit withdrawal and administration of the volume specified on the label. DESCRIPTION Papaverine Hydrochloride, USP, is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. It does not contain a phenanthrene group as do morphine and codeine. Papaverine Hydrochloride, USP, is 6,7-dimethoxy-1- veratrylisoquinoline hydrochloride and contains, on the dried basis, not less than 98.5% of C H NO •HCI. The molecular weight is 375.85. The structural formula is as shown. Papaverine Hydrochloride occurs as white crystals or white crystalline powder. One gram dissolves in about 30 mL of water and in 120 mL of alcohol. It is soluble in chloroform and practically insoluble in ether. Papaverine Hydrochloride Injection, USP, is a clear, colorless to pale-yellow solution. Papaverine Hydrochloride, for parenteral administration, is a smooth-muscle relaxant that is available in vials containing 30 mg/mL. Each vial also contains edetate disodium 0.005%. The 10 mL vials also contain chlorobutanol 0.5% as a preservative. pH may be adjusted with sodium citrate and/or citric acid. CLINICAL PHARMACOLOGY The most characteristic effect of papaverine is relaxation of the tonus of all smooth 20 21 4 muscle, especially when it has been spasmodically contracted. Papaverine Hydrochloride apparently acts directly on the muscle itself. This relaxation is noted in the _vascular_ _system _and _bronchial musculature _and in the _gastrointestinal, biliary _and _urinary tracts_. The main actions of papaverine are exerted on Leer el documento completo