País: Nueva Zelanda
Idioma: inglés
Fuente: Medsafe (Medicines Safety Authority)
Sodium cromoglicate 20mg;
Douglas Pharmaceuticals Limited
Sodium cromoglicate 20 mg
20 mg
Powder for inhalation
Active: Sodium cromoglicate 20mg
Blister pack, use with spinhaler, 50 dose units
Prescription
Prescription
Aventis Pharma Manufacturing Pte Ltd
Package - Contents - Shelf Life: Blister pack, use with spinhaler - 50 dose units - 36 months from date of manufacture stored at or below 30°C
1969-12-31
INTAL SPINCAPS _SODIUM CROMOGLICATE 20 MG CAPSULES _ NAME OF THE MEDICINE INTAL SPINCAPS Sodium Cromoglicate 20 mg capsules. DESCRIPTION Sodium cromoglicate is a white or almost white, crystalline powder. The chemical name of sodium cromoglicate is disodium 5,5’-[(2-hydroxypropane-1,3- diyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylate. The molecular formula of sodium cromoglicate is C 23 H 14 Nz 2 O 11 and the molecular weight is 512.3. The structural formula is: INTAL SPINCAPS are micronised sodium cromoglicate in a yellow/colourless gelatin capsule, overprinted with “SODIUM CROMOGLICATE 20 mg” for use with the SPINHALER inhalation device. PHARMACOLOGY _MECHANISM OF ACTION _ Sodium cromoglicate is a derivative of chromone-2-carboxylic acid, which inhibits the activation of many of the cell types involved in the development and progression of asthma. Thus, sodium cromoglicate prevents the formation of IgE antibody or B lymphocytes, inhibits the release of inflammatory mediators including cytokines form mast cells and reduces the chemotactic activity of eosinophils and neutrophils. Activation and mediator release from monocytes and macrophages is also reduced with sodium cromoglicate. Sodium cromoglicate inhibits antigen-induced early and late phase airway obstruction in conscious animals and reduces the influx of inflammatory cells into the airways. The drug also inhibits sensory nerve (C fibre) activation in the dog lung and inflammatory responses in the airways of animals induced by neuronal stimulation. This diverse range of activities of the drug may be explained by the ability of sodium cromoglicate to block chloride channels in different cell types that are important in cell activation. In acute bronchial provocation tests sodium cromoglicate has been shown to inhibit or diminish the Leer el documento completo