País: Malasia
Idioma: inglés
Fuente: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
COLCHICINE
Noripharma Sdn. Bhd.
COLCHICINE
60tablet Tablets; 100tablet Tablets; 1000tablet Tablets; 500tablet Tablets
Noripharma Sdn. Bhd.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ GOUTNOR TABLET Colchicine (0.5mg, 0.6mg) 1 WHAT IS IN THIS LEAFLET 1. What Goutnor is used for 2. How Goutnor works 3. Before you use Goutnor 4. How to take Goutnor 5. While you are using Goutnor 6. Side effects 7. Storage and disposal of Goutnor 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT GOUTNOR IS USED FOR Colchicine is an anti-gout agent. Goutnor are used to treat acute gout. They are also used to prevent flare-ups of gout when treatment is started with allopurinol and uricosuric drugs. HOW GOUTNOR WORKS In gout, crystals of uric acid are deposited in joints causing pain and inflammation. Colchicine is considered to act against the inflammatory response to urate crystals, by possibly inhibiting the migration of granulocytes into the inflamed area. Other properties of colchicine, such as interaction with the microtubules, could also contribute to the operation. BEFORE YOU USE GOUTNOR _When you must not use it _ Do not take Colchicine if: you are allergic to colchicine or any of the other ingredients of this medicine you have blood disorder you are pregnant you are breast-feeding you have severe kidney or liver problems you are undergoing haemodialysis you have uric acid kidney stone You are under 2 years of age If you are not sure whether any of the above apply to you, talk to your doctor or pharmacist before taking colchicine tablets. _Before you start to use it _ Talk to your doctor or pharmacist before taking Colchicine Tablets if you: have problems with your heart, kidneys, liver or digestive system are elderly and weak have a blood disorder have intolerance to some sugars (This product contains lactose) _Taking other medication _ Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. When Colchicine Tablets are taken together with any of the following medicines, side effects due to colchicine toxicity are m Leer el documento completo
1 GOUTNOR 0.5MG TABLET COMPOSITION: Each tablet contains Colchicine 0.5mg DESCRIPTION: A white to off white round shaped tablet with ‘C’ engraved on one side. PHARMACODYNAMICS: Colchicine acts against the inflammatory response to urate crystals, by possibly inhibiting the migration of granulocytes into the inflamed area. This reduces the release of lactic acid and proinflammatory enzymes that occurs during phagocytosis and breaks the cycle that leads to the inflammatory response. PHARMACOKINETICS: Peak plasma concentrations of colchicines are reached within 2 hours of oral administration. Colchicine is partially deacetylated in the liver and unchanged drug and its metabolites are excreted in the bile and undergo intestinal reabsorption. Colchicine is found in high concentration in leucocytes, kidneys and the liver and spleen. Most of the drug is excreted in the faeces but 10% to 20% is excreted in the urine and this proportion rises in patients with liver disorders. INDICATION: For the treatment of acute gout, and for the prophylaxis of recurrent gout and to prevent acute attacks during initial therapy with allopurinol and uricosuric drugs. RECOMMENDED DOSE: For oral administration For treatment of acute gout: 1mg initially then 0.5mg every 2-3 hours until pain is relieved or diarrhoea or vomiting or until a total dose of 6mg is reached. Do not repeat the course of treatment within 3 days. For prophylaxis; 0.5mg two or three times daily. ROUTE OF ADMINISTRATION: Oral administration CONTRAINDICATION: The use of colchicine is contraindicated in pregnancy and lactation people who are hypersensitive to colchicines children under 2 years of age blood dyscrasias uric acid kidney stones Colchicine should not be used in patients undergoing haemodialysis since it cannot be removed by dialysis or exchange transfusion. WARNING AND PRECAUTIONS: Colchicine should be given with care to elderly and debilitated patients who may be particularly susceptible to cumulative toxicity; and to those with cardiac, Leer el documento completo