EPHEDRINE SULFATE injection, solution

País: Estados Unidos

Idioma: inglés

Fuente: NLM (National Library of Medicine)

Ingredientes activos:

Ephedrine Sulfate (UNII: U6X61U5ZEG) (Ephedrine - UNII:GN83C131XS)

Disponible desde:

Nexus Pharmaceuticals Inc

Designación común internacional (DCI):

Ephedrine Sulfate

Composición:

Ephedrine Sulfate 50 mg in 1 mL

Vía de administración:

INTRAVENOUS

tipo de receta:

PRESCRIPTION DRUG

indicaciones terapéuticas:

Ephedrine Sulfate Injectionn, USP is indicated in the treatment of allergic disorders, such as bronchial asthma The drug has long been used as a pressor agent, particularly during spinal anesthesia when hypotensionn frequently ooccurs. In Stokes-Adams syndromeme with complete heart block, ephedrine has a value similar to that of epinephrine. It is indicated as a central nervous system stimulant in narcolepsy and depressive states. It is also used in myasthenia gravis. Allergic reactions to ephedrine sulfate are rare. The hypersensitivity, if known, is a specific contraindication. Patients hypersensitive to other sympathomimetics may also be hypersensitive to ephedrine sulfate. Prolonged abuse of Ephedrine Sulfate Injection, USP can lead to symptoms of paranoid schizophrenia. When this occurs, patients exhibit such physical signs as tachycardia, poor nutrition and hygiene, fever, cold sweat and dilated pupils. Some measure of tolerance may develop with prolonged or excessive use but addiction does not occur. T

Resumen del producto:

Ephedrine Sulfate Injection USP, 50 mg/mL 1 mL vial in packs of 10, NDC 14789-014-01 STORAGE: Store at 20 ° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light.

Estado de Autorización:

unapproved drug other

Ficha técnica

EPHEDRINE SULFATE- EPHEDRINE SULFATE INJECTION, SOLUTION
NEXUS PHARMACEUTICALS INC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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EPHEDRINE SULFATE INJECTION USP, 50 MG/ML
Forr IM, IV or SC Use
RX ONLY
DESCRIPTION
Ephedrine Sulfate Injection, USP is a sterile solutionn of 50 mg
ephedrine sulfate in Water for Injection.
Ephedrine ooccurs as fine, white, oodorless crystals or powder and
darkens on exposure to light. It is
freely soluble in water and sparingly soluble in alcohol.
The chemical name of ephedrine sulfate is (C
H NO) •H SO benzenemethanol α-[l - (methylamino)
ethyl] - sufate (2:1) (salt). Its molecular weight is 428 .54. The
structural formula is:
CLINICAL PHARMACOLOGY
Ephedrine sulfate is a potent sympathomimetic that stimulates both α
and β receptors and has clinical
uses related to both actions. Its peripheral actions, which it owes in
part to the release of
norepinephrine, simulate responses that are obtained when adrenegenic
nerves are stimulated. These
include an increase in blood pressure, stimulation of heart muscle,
constriction of arterioles, relaxation
of the smooth muscle of the bronchi and gastrointestinal tract, and
dilation of the pupils. In the bladder,
relaxation of the detrusor muscle is not prominent, but the tone of
the trigone and vesicle sphincter is
increased.
Ephedrine sulfate also has a potent effect on the CNS. It stimulates
the cerebral cortex and sub-cortical
centers, which accounts for its use in narcolepsy.
The cardiovascular responses reported in man include moderate
tachycardia, unchanged or augmened
stroke volume, enhanced cardiac output, variable alterations in
peripheral resistance and usually a rise in
blood pressure. The action of ephedrine is more prominent on the heart
than on the blood vessels.
Ephedrine sulfate increases the flow of coronary, cerebral and muscle
blood.
In patients with myasthenia gravis, admini