País: Estados Unidos
Idioma: inglés
Fuente: NLM (National Library of Medicine)
CALCITRIOL (UNII: FXC9231JVH) (CALCITRIOL - UNII:FXC9231JVH)
Avera McKennan Hospital
CALCITRIOL
CALCITRIOL 0.5 ug
PRESCRIPTION DRUG
Abbreviated New Drug Application
CALCITRIOL- CALCITRIOL CAPSULE, LIQUID FILLED AVERA MCKENNAN HOSPITAL ---------- CALCITRIOL CAPSULES 0.5 MCG RX ONLY DESCRIPTION Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. It is available as capsules containing 0.25 mcg or 0.5 mcg calcitriol. Each capsule also contains the following inactive ingredients: butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) as antioxidants, and triglycerides (medium chain). Gelatin capsule shell contains gelatin, glycerol, mannitol, red iron oxide, sorbitanhydrides, sorbitol, superior polyols, titanium dioxide and yellow iron oxide. Imprinting ink contains propylene glycol, shellac modified, and titanium dioxide. Calcitriol is a white, crystalline compound which occurs naturally in humans. It is soluble in organic solvents but relatively insoluble in water. Chemically, calcitriol is 9,10-seco(5Z,7E)-5,7,10(19)- cholestatriene-1α,3β,25-triol and has the following structural formula: C H O M.W. 416.65 The other names frequently used for calcitriol are 1α,25-dihydroxycholecalciferol, 1,25- dihydroxyvitamin D , 1,25-DHCC, 1,25(OH) D and 1,25-diOHC. CLINICAL PHARMACOLOGY Man’s natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol in the skin to vitamin D (cholecalciferol). Vitamin D must be metabolically activated in the liver and the kidney before it is fully active as a regulator of calcium and phosphorus metabolism at target tissues. The initial transformation of vitamin D is catalyzed by a vitamin D -25-hydroxylase enzyme (25-OHase) present in the liver, and the product of this reaction is 25-hydroxyvitamin D [25-(OH)D ]. Hydroxylation of 25-(OH)D occurs in the mitochondria of kidney tissue, activated by the renal 25-hydroxyvitamin D -1 alpha-hydroxylase (alpha-OHase), to produce 1,25-(OH) D (calcitriol), the active form of vitamin D . Endogenous synthesis and cata Leer el documento completo