CALCITRIOL capsule liquid filled

País: Estados Unidos

Idioma: inglés

Fuente: NLM (National Library of Medicine)

Ingredientes activos:

CALCITRIOL (UNII: FXC9231JVH) (CALCITRIOL - UNII:FXC9231JVH)

Disponible desde:

Cardinal Health

Designación común internacional (DCI):

CALCITRIOL

Composición:

CALCITRIOL 0.25 ug

tipo de receta:

PRESCRIPTION DRUG

Estado de Autorización:

Abbreviated New Drug Application

Ficha técnica

CALCITRIOL- CALCITRIOL CAPSULE, LIQUID FILLED
CARDINAL HEALTH
----------
CALCITRIOL CAPSULES, 0.25 MCG AND 0.5 MCG
0657
0658
RX ONLY
DESCRIPTION
Calcitriol is a synthetic vitamin D analog which is active in the
regulation of the absorption of calcium
from the gastrointestinal tract and its utilization in the body. It is
available as capsules containing 0.25
mcg or 0.5 mcg calcitriol. Each capsule also contains the following
inactive ingredients: butylated
hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) as
antioxidants, and triglycerides (medium
chain). Gelatin capsule shell contains gelatin, glycerol, mannitol,
red iron oxide, sorbitanhydrides,
sorbitol, superior polyols, titanium dioxide and yellow iron oxide.
Imprinting ink contains ammonium
hydroxide, isopropyl alcohol, propylene glycol, shellac and titanium
dioxide.
Calcitriol is a white, crystalline compound which occurs naturally in
humans. It is soluble in organic
solvents but relatively insoluble in water. Chemically, calcitriol is
9,10-seco(5Z,7E)-5,7,10(19)-
cholestatriene-1α,3β,25-triol and has the following structural
formula:
C
H O M.W. 416.65
The other names frequently used for calcitriol are
1α,25-dihydroxycholecalciferol, 1,25-
dihydroxyvitamin D , 1,25-DHCC, 1,25(OH) D and 1,25-diOHC.
CLINICAL PHARMACOLOGY
Man’s natural supply of vitamin D depends mainly on exposure to the
ultraviolet rays of the sun for
conversion of 7-dehydrocholesterol in the skin to vitamin D
(cholecalciferol). Vitamin D must be
metabolically activated in the liver and the kidney before it is fully
active as a regulator of calcium and
phosphorus metabolism at target tissues. The initial transformation of
vitamin D is catalyzed by a
vitamin D -25-hydroxylase enzyme (25-OHase) present in the liver, and
the product of this reaction is
25-hydroxyvitamin D [25-(OH)D ]. Hydroxylation of 25-(OH)D occurs in
the mitochondria of kidney
tissue, activated by the renal 25-hydroxyvitamin D -1
alpha-hydroxylase (alpha-OHase), to produce
1,25-(OH) D (calcitriol), the active form