BUMETANIDE tablet

País: Estados Unidos

Idioma: inglés

Fuente: NLM (National Library of Medicine)

Ingredientes activos:

BUMETANIDE (UNII: 0Y2S3XUQ5H) (BUMETANIDE - UNII:0Y2S3XUQ5H)

Disponible desde:

Lake Erie Medical DBA Quality Care Products LLC

Designación común internacional (DCI):

BUMETANIDE

Composición:

BUMETANIDE 0.5 mg

tipo de receta:

PRESCRIPTION DRUG

Estado de Autorización:

Abbreviated New Drug Application

Ficha técnica

BUMETANIDE- BUMETANIDE TABLET
LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC
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BUMETANIDE TABLETS USP
WARNING
Bumetanide is a potent diuretic which, if given in excessive amounts,
can lead to a profound
diuresis with water and electrolyte depletion. Therefore, careful
medical supervision is required,
and dose and dosage schedule have to be adjusted to the individual
patient’s needs. (See
DOSAGE AND ADMINISTRATION.)
DESCRIPTION
Bumetanide is a loop diuretic, available as scored tablets, 0.5 mg
(light green), 1 mg (yellow) and 2 mg
(peach) for oral administration; each tablet also contains: anhydrous
lactose, magnesium stearate,
microcrystalline cellulose, corn starch and talc, with the following
colorants: 0.5 mg (D&C Yellow No.
10 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake); 1 mg (D&C Yellow
No. 10 Aluminum
Lake); 2 mg (Ferric oxide red).
Chemically, bumetanide is 3-(butylamino)-4-phenoxy-5-sulfamoyl-benzoic
acid. It is a practically white
powder. It is slightly soluble in water and soluble in alkaline
solutions. It has the following structural
formula:
CLINICAL PHARMACOLOGY
Bumetanide is a loop diuretic with a rapid onset and short duration of
action. Pharmacological and
clinical studies have shown that 1 mg bumetanide has a diuretic
potency equivalent to approximately 40
mg furosemide. The major site of bumetanide action is the ascending
limb of the loop of Henle. The
mode of action has been determined through various clearance studies
in both humans and experimental
animals. Bumetanide inhibits sodium reabsorption in the ascending limb
of the loop of Henle, as shown
by marked reduction of free-water clearance (
H O) during hydration and tubular free-water
reabsorption (T H O) during hydropenia. Reabsorption of chloride in
the ascending limb is also
blocked by bumetanide, and bumetanide is somewhat more chloruretic
than natriuretic.
Potassium excretion is also increased by bumetanide, in a dose-related
fashion.
Bumetanide may have an additional action in the proximal tubule. Since
phosphate rea