País: Singapur
Idioma: inglés
Fuente: HSA (Health Sciences Authority)
Sodium Iodide [I-131]
TRANSMEDIC PTE LTD
V10XA01
CAPSULE
Sodium Iodide [I-131] 50 to 6000 MBq/capsule
ORAL
Prescription Only
ANSTO
ACTIVE
2021-03-08
ANSTO - SODIUM IODIDE [131I] THERAPY CAPSULES (50 TO 6000 MBQ) DESCRIPTION Sodium Iodide [ 131 I] Therapy Capsules are supplied for oral administration as pale yellow gelatin capsules containing sodium iodide [ 131 I] solution adsorbed on an inert filler (anhydrous di-sodium hydrogen phosphate). Other excipients include sodium bicarbonate solution and water for Injection. A range of iodine-131 content is available, from 50 MBq to 6000MBq at the time of calibration at 0900 hrs (Sydney time) each Monday. Each capsule is contained in a glass serum vial sealed with a rubber stopper and red aluminium seal. The vial is in turn contained in an appropriate lead container. A special lead shielded decapping pot and decapping pliers are supplied free with the initial order. PHYSICAL CHARACTERISTICS OF [ 131 I] Iodine-131 with a physical half-life of 8.04 days, decays by beta emission (average energy 182 keV) with associated gamma emission. Stable xenon-131 is formed in 98.9% of decays and radioactive xenon -131m (half-life 11.9 days) in 1.1% of decays. The principal beta emissions and gamma photons are listed in Table 1. TABLE 1: PRINCIPAL RADIATION EMISSION DATA PRINCIPAL RADIATION MEAN % PER DISINTEGRATION MEAN ENERGY (KEV) Beta1 2.1 69.4 (Avg.) Beta3 7.3 96.6 (Avg.) Beta4 89.4 191.5 (Avg.) Gamma7 6.1 284.3 Gamma14 81.2 364.5 Gamma17 7.3 637.0 Gamma19 1.8 722.9 _Reference: Weber DA, Eckerman KF, Dillman LTand Ryman J C, MIRD: Radionuclide Data and _ _Decay Schemes, The Society of Nuclear Medicine,1989. _ TABLE2: PHYSICAL DECAY CHART FOR[ 131 I] DAYS FRACTION REMAINING DAYS FRACTION REMAINING 0 1.000 8 0.502 1 0.917 9 0.460 2 0.842 10 0.422 3 0.772 11 0.387 4 0.708 12 0.355 5 0.650 13 0.326 6 0.596 14 0.299 7 0.547 SODIUM IODIDE [131I] THERAPY CAPSULES 2 EXTERNAL RADIATION The specific gamma ray constant for iodine-131 at 1 cm. The first half-value thickness of lead is 0.26 cm and a lead thickness of 2.6cm will produce an attenuation factor of about 10 -2. Attenuation by lead is given in Table 3. TABLE 3: PRINCIPAL RADIATI Leer el documento completo