喜革脈錠２．５公絲

País: Taiwán

Idioma: chino

Fuente: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)

Ingredientes activos:

NICORANDIL

Disponible desde:

台灣中外製藥股份有限公司 台北市松山區敦化北路260號3樓 (23060795)

Código ATC:

C01DX16

formulario farmacéutico:

錠劑

Composición:

NICORANDIL (2412003400) MG

Unidades en paquete:

盒裝

clase:

製　劑

tipo de receta:

須由醫師處方使用

Fabricado por:

CHUGAI PHARMACEUTICAL CO., LTD. 5-1, UKIMA 5-CHOME, KITA-KU, TOKYO, JAPAN JP

Área terapéutica:

nicorandil

indicaciones terapéuticas:

狹心症

Resumen del producto:

註銷日期: 2020/09/01; 註銷理由: 自請註銷; 有效日期: 2025/07/17; 英文品名: SIGMART TABLETS 2.5MG

Estado de Autorización:

已註銷

Fecha de autorización:

2020-04-09

Información para el usuario

20171020181(12)
PDE 5 (phosphodiesterase type 5)
(sildenafil citrate “Viagra
®
”vardenafil hydrochloride trihydrate
“Levitra
®
”
tadalafil “CIALIS
®
”)GC (guanylate
cyclase)(riociguat)
Sigmart
®
(
3.)
3.
()
SIGMART
®
2.5mg
Nicorandil 2.5mg
݊ PP
2 mm
C-21F
50 mg
SIGMART
®
5mg
Nicorandil 5mg
()
݊ PP
2 mm
&)Â
50 mg
Carboxymethylcellulose Calcium, Corn Starch,
Calcium stearate, Stearyl alcohol, D-mannitol
(1)
cGMP
PDE 5
cGMP
PDE
5
cGMP
PDE5
Sildenafil citrate
(Viagra
®
, Revatio
®
)
Vardenafil hydrochloride
trihydrate (Levitra
®
)
Tadalafil (CIALIS
®
)
GC
cGMP
GC
cGMP
GC
Riociguat
(ADEMPAS
®
)
()
Nicorandil
15 mg3
1.
()
(1) []
(2) []
(3) (5.)
(4) NYHA III
IV
2.
(1)
(2) PDE 5(sildenafil citrate “Viagra
®
”vardenafil
hydrochloride trihydrate “Levitra
®
”tadalafil “Cialis
®
”)
GC(riociguat)
PDE 5GC(riociguat)
PDE 5GC(riociguat)
(3)
(
)
(4) (
)
(filling pressure)
(cardiac decompensation)
(5) G6PD (glucose 6 phosphate dehydrogenase)
(nitrate)
(nitrite)
G6PD
(methemoglobihaemia)
4.
14,323
661
(4.61
)
817
(
)515(3.60)
63
(0.44
)21
(0.15
)20
(0.14
)
() 17(0.12)()
(1)
1) (
)
AST (GOT)
ALT (GPT)
Ȗ*73
2) (
)
3) (
)
(2)
3>
0.1
<0.1
GOT
GPTAl-P
3
2
3
3
3
4
1
®
5
®
2.5
SIGMART
® TABLETS 5MG 2.5MG
NICORANDIL
5mg
020991
2.5mg
020992
®
(SIGMART
®
Tablets)
25
AUC
0-4
KUÂQJP/
262.5±43.1
C
max
QJP/
152.3±29.2
T
max
(hr)
0.55±0.12
t

(hr)
0.75
SIGMART
® ()
()10mg
5.
6.
7.
8.
:
PTP
PTP
PTP
PTP
1.
5
SIGMART
®
5mg2
(10mg Nicorandil)
Nicorandil
1)
1.
(1)
Langendorff's
Nicorandil
Nicorandil
Nicorandil
6,7)
(2)
1) Nicorandil
Nicorandil
Langendorff's
7-11)
2)
6
SIGMART
®
(5mg Nicorandil)(
)120
(pacing)
()
()
(118~120%)
12)
(3)
Nicorandil
ST
Methacholine
Noradrenaline
Nicorandil
13,14)
(4)
1)
Nicorandil
8,9,15)
2)
6
SIGMART
®
(5mg Nicorandil)
pressure-rate product
12)
2.
Nicorandil
Nicorandilguanylate
cyclase
cyclic-GMP
Nitrates
Nitrites(in vitro)Nicorandil
Nicorandil (JAN)
N-(2-hydroxyethyl)nicotinamide nitrate (ester)
Chugai Pharmaceutical Co., Ltd.
5-1, Ukima 5-chome, Kita-