ZYDAX 250 INJECTION

Country: Australia

Language: English

Source: APVMA (Australian Pesticides and Veterinary Medicines Authority)

Active ingredient:

PENTOSAN POLYSULFATE SODIUM

Available from:

PARNELL TECHNOLOGIES PTY LTD

INN (International Name):

sodium pentosan polysulfate(250mg/mL)

Pharmaceutical form:

PARENTERAL LIQUID/SOLUTION/SUSPENSION

Composition:

PENTOSAN POLYSULFATE SODIUM MINERAL-SODIUM Active 250.0 mg/ml

Units in package:

20mL; 50mL; 6mL

Class:

VM - Veterinary Medicine

Manufactured by:

PARNELL TECHNOLOGIES

Therapeutic group:

HORSE | COLT | DONKEY | ENDURANCE HORSE | FILLY | FOAL | GELDING | HIGH PERFORMANCE HORSES | HORSES AT STUD | MARE | PACER | POL

Therapeutic area:

MUSCULOSKELETAL SYSTEM

Therapeutic indications:

INFLAMMATORY JOINT DISEASE | NON-INFECTIOUS JOINT DISEASE

Product summary:

Poison schedule: 4; Withholding period: WHP: Meat (Horses): 28 days.; Host/pest details: HORSE: [INFLAMMATORY JOINT DISEASE]; Poison schedule: 4; Withholding period: ; Host/pest details: HORSE: [INFLAMMATORY JOINT DISEASE]; An aid in the treatment of non-infectious, inflammatory joint disease in horses.Do not use in horses suffering from clotting defects, traumatic haemorrhage, infection or liver or kidney failure or within 2 days of surgery

Authorization status:

Registered

Authorization date:

2023-07-01

Patient Information leaflet

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PRESCRIPTION ANIMAL REMEDY
KEEP OUT OF REACH OF CHILDREN
FOR ANIMAL TREATMENT ONLY
ACTIVE CONSTITUENT
PENTOSAN POLYSULFATE SODIUM 250mg/mL
AN AID IN THE TREATMENT OF NON-INFECTIOUS,
INFLAMMATORY JOINT DISEASE IN HORSES.
PHARMACOLOGY
Pentosan polysulfate (PPS) is a semisynthetic polysaccharide
with a linear xylan (pentosan) backbone. Xylan is a hemicellulose
derived from plant origin by extraction from the cell walls of
hardwoods. PPS possesses antiinflammatory, antiarthritic and
chondroprotective activities.
The beneficial effects of pentosan polysulfate in joint disease
are due to the following actions:
1.
Antiinflammatory activity
2.
Inhibition of neutrophil migration into the joint
3.
Stimulation of hyaluronic acid synthesis by synovial
fibroblasts, resulting in increased volume and viscosity of
synovial fluid
4.
Stimulation of proteoglycan synthesis by chondrocytes
5.
Fibrinolytic activity, resulting in improve

Summary of Product characteristics

PAGE 1 OF 2
MATERIAL SAFETY DATA SHEET:
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE
COMPANY/UNDERTAKING
PRODUCT NAME : Zydax 100 Injection & Zydax 250 Injection_ _
OTHER NAMES : PPS, PPS Injection, Pentosan, Pentosan Polysulfate,
Cartrophen
RECOMMENDED USE: FOR ANIMAL TREATMENT ONLY.
An aid in the treatment of non-infectious joint disease in dogs (Zydax
100) /horses (Zydax 250)
MANUFACTURER COMPANY DETAILS:
LICENSEE (NEW ZEALAND) DETAILS:
Parnell Manufacturing Pty Ltd
Parnell NZ Co
ADDRESS
ADDRESS
Unit 4, Century Estate
PO Box 73160
476 Gardeners Road
Auckland International Airport
Alexandria, NSW 2015
Manukau 2150
Australia
New Zealand
TELEPHONE NUMBER
TELEPHONE NUMBER
61 (0)2-9667 4411
0800 446 282 (Toll free within NZ)
EMERGENCY TELEPHONE NUMBER
EMERGENCY TELEPHONE NUMBER
61 (0)2-9667 4411 (Business Hours)
0800 446 282 (Business Hours)
FACSIMILE NUMBER
FACSIMILE NUMBER
61 (0)2-9667 4139
0800 727 533 (Toll free within NZ)
2. HAZARDS IDENTIFICATION
Hazardous substance according to criteria of Worksafe Australia.
3. COMPOSITION/INFORMATION ON INGREDIENTS
CHEMICAL ENTITY
CAS NUMBER
PROPORTION
Pentosan Polysulfate Sodium
116001-96-8
10% / 25% w/v
Antimicrobial Preservative
< 5% w/v
Buffers
< 5% w/v
Water
7732-18-5
to 100%
4. FIRST AID MEASURES
SWALLOWED: If poisoning occurs, contact a doctor or Poisons
Information Centre.
EYE: If in eyes, hold eyes open, flood with water for at least 15
minutes. Seek medical assistance if required.
SKIN: If skin contact occurs remove contaminated clothing and wash
skin thoroughly with soap and water.
INHALED: No specific requirements.
FIRST AID FACILITIES: No specific first aid facilities required.
ADVICE TO DOCTOR: Treat symptomatically as required.
5. FIRE-FIGHTING MEASURES
This material is not considered a fire hazard. Use standard fire
fighting techniques to extinguish fires involving
this material. Use water spray, dry chemical, carbon dioxide or foam.
6. ACCIDENTAL RELEASE MEASURES
Clean up spilled material with absorbent ensuring no contact with skin
during ope