XYLAZINE injection, solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

XYLAZINE HYDROCHLORIDE (UNII: NGC3S0882S) (XYLAZINE - UNII:2KFG9TP5V8)

Available from:

COVETRUS

Administration route:

INTRAMUSCULAR

Prescription type:

PRESCRIPTION

Therapeutic indications:

INDICATIONS Xylazine should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer, and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. Horses: Xylazine has been used successfully as follows: 1.  Diagnostic procedures-oral and ophthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations. 2.  Orthopedic procedures, such as application of casting materials and splints. 3.  Dental procedures. 4.  Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations. 5.  To calm and facilitate handling of fractious animals. 6.  Therapeutic medication for sedation and relief of pain following injury or surgery. 7.  Major surgical procedures:       a.When used as a preanesthetic to general anesthesia.       b.When used in conjunction with local anesthetics. Cervidae: Xylazine may be used for the following: 1.  To calm and facilitate handling of fractious animals. 2.  Diagnostic procedures. 3.  Minor surgical procedures. 4.  Therapeutic medication for sedation and relief of pain following injury or surgery. 5.  As a preanesthetic to local anesthesia. Xylazine at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine.

Product summary:

HOW SUPPLIED Xylazine (xylazine injection) 100 mg/mL for intravenous or intramuscular use is available in 50 mL multiple dose vials.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

XYLAZINE- XYLAZINE INJECTION, SOLUTION
COVETRUS
----------
XYLAZINE INJECTION
100 MG/ML
SEDATIVE AND ANALGESIC FOR USE IN HORSES AND _CERVIDAE _ONLY
DESCRIPTION
Xylazine (xylazine injection) is supplied in 50 mL multipledose vials
as a sterile solution.
Each mL contains 100 mg xylazine (xylazine base equivalent); 0.9 mg
methylparaben;
0.1 mg propylparaben; water for injection; citric acid and sodium
citrate for pH
adjustment to 5.5 ± 0.3.
ACTIVE INGREDIENT:
Xylazine hydrochloride
.....................................................................................
11.7%
(Equivalent to 10% base)
INERT
INGREDIENTS:................................................................................................88.3%⁄100.0%
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian. Do
not use in Cervidae less than 15 days before or during the hunting
season.
PHARMACOLOGY
Xylazine, a non-narcotic compound, is a sedative and analgesic as well
as muscle
relaxant. Its sedative and analgesic activity is related to central
nervous system
depression. Its muscle- relaxant effect is based on inhibition of the
intraneural
transmission of impulses in the central nervous system. The principal
pharmacological
activities develop within 10 to 15 minutes after intramuscular
injection, and within 3 to 5
minutes following intravenous administration in horses.
A sleeplike state, the depth of which is dose-dependent, is usually
maintained for 1 to 2
hours, while analgesia lasts from 15 to 30 minutes. The
centrally-acting muscle relaxant
effect causes relaxation of the skeletal musculature, complementing
sedation and
analgesia.
In horses and_ Cervidae_ under the influence of Xylazine (xylazine
injection), the
respiratory rate is reduced as in natural sleep. Following treatment
with Xylazine
(xylazine injection), the heart rate is decreased and a transient
change in the
conductivity of the cardiac muscle may occur, as evidenced by a
partial atrioventricular
block. This resembles the atrioventricular bl