XENON, XE-133- xenon gas

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

XENON XE-133 (UNII: X3P9A5HNYF) (XENON XE-133 - UNII:X3P9A5HNYF)

Available from:

Curium US LLC

INN (International Name):

XENON XE-133

Composition:

XENON XE-133 5 mCi in 1 mL

Administration route:

RESPIRATORY (INHALATION)

Prescription type:

PRESCRIPTION DRUG

Therapeutic indications:

Xenon Xe 133 Gas has been shown to be valuable for diagnostic inhalation studies for the evaluation of pulmonary function, for imaging the lungs and may also be applied to assessment of cerebral blood flow. None known.

Product summary:

Xenon Xe 133 Gas is available in 2 milliliter vials with color-coded labels in 370 megabecquerel (10 millicurie; Catalog No. 097) and 740 megabecquerel (20 millicurie; Catalog No. 098) sizes. Both sizes are available in packages of 1, 3 and 5 vials, each with individual lead shielding.

Authorization status:

New Drug Application

Summary of Product characteristics

XENON, XE-133- XENON GAS
CURIUM US LLC
----------
XENON XE 133 GAS
RX ONLY
_DIAGNOSTIC_
DESCRIPTION
Xenon Xe 133 Gas is for diagnostic inhalation use only. It is supplied
in vials containing
either 370 or 740 megabecquerels (10 or 20 millicuries) of Xenon Xe
133 Gas in 2
milliliters of carrier xenon and atmospheric air.
Xenon Xe 133 Gas is chemically and physiologically similar to
elemental xenon, a non-
radioactive gas which is physiologically inert except for anesthetic
properties at high
doses.
Xenon Xe 133 is produced by fission of Uranium U 235. At the time of
calibration, it
contains no more than 0.3% Xenon Xe 133m, no more than 1.5% Xenon Xe
131m, no
more than 0.06% Krypton Kr 85 and no more than 0.01% Iodine I 131,
with no less than
99.9% total radioactivity as radioxenon. Table 1 shows the effect of
time on radionuclidic
composition.
_Table 1. Radionuclidic Composition_
*
†
Percent of Total Radioactivity
Days
% Xe-
133
% Xe-
133m
%
Xe-
131m
% Kr-
85
% I-
131
-5
>98.3 <0.6 <1.0 <0.03<0.01
0
>98.1 <0.3 <1.5 <0.06<0.01
7
>97.2<0.08 <2.5 <0.15<0.02
14
>95.7<0.02 <4.1 <0.37<0.02
PHYSICAL CHARACTERISTICS
Xenon Xe 133 decays by beta and gamma emissions with a physical
half-life of 5.245
days.
Photons that are useful for detection and imaging studies as well as
the principal
beta emission are listed in Table 2.
_Table 2. Principal Radiation Emission Data_
Radiation
Mean % Per
Disintegration
Energy
(keV)
100.6
Calibration Date
Expiration Date
*
†
1
Beta-2
99.3
100.6
Avg.
Gamma-2
36.5
81.0
K alpha x-
rays
38.9
30.8
Avg.
K beta x-
rays
9.1
35.0
Avg.
1
EXTERNAL RADIATION
The specific gamma ray constant for Xenon Xe 133 is 0.51 R/hr-mCi at 1
cm. The first
half-value thickness is 0.0035 cm of Pb.
A range of values for the relative attenuation of the radiation
emitted by this radionuclide
that results from interposition of various thicknesses of Pb is shown
in Table 3. For
example, the use of 0.2 cm of Pb will decrease the external radiation
exposure by a
factor of about 1000.
_Table 3. Radiation Attenuation by Lea