VITABION (TABLETS)

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

THIAMINE MONONITRATE; Pyridoxine hydrochloride; Cyanocobalamin

Available from:

MEDISPEC (M) SDN.BHD

INN (International Name):

THIAMINE MONONITRATE; Pyridoxine hydrochloride; Cyanocobalamin

Units in package:

500Tablet Tablets

Manufactured by:

Unison Laboratories Co. Ltd.

Summary of Product characteristics

Each film coated tablet contains:
THIAMINE MONONITRATE (VITAMIN B1) 100 MG
PYRIDOXINE HYDROCHLORIDE (VITAMIN B6) 200 MG
CYANOCOBALAMIN (VITAMIN B12) 200 MCG
INDICATION:
DOSAGE AND ADMINISTRATION:
_PHARMACOLOGY_
Thiamine combines with adenosine triphosphate (ATP) to form a
coenzyme, thiamine pyrophosphate (thiamine diphosphate,
cocarboxylase), which is necessary for carbohydrate metabolism.
Pyridoxine is converted in erythrocytes to pyridoxal phosphate and to
a lesser extent pyridoxine phosphate, which act as coenzymes for
various metabolic functions affecting protein, carbohydrate,
and lipid utilization. Pyridoxine is involved in conversion of
tryptophan to niacin or serotonin, breakdown of glycogen to glucose- 1
phosphate, conversion of oxalate to glycine, synthesis of
gamma aminobutyric acid (GABA) within the CNS, and synthesis of heme.
Cyanocobalamin acts as coenzyme for various metabolic functions,
including fat and carbohydrate metabolism and protein synthesisIt is
necessary for growth, cell replication, hematopoiesis, and
nucleoprotein and myelin synthesis, largely due to its effects
onmetabolism of methionine, folic acid, and malonic acid.
_PHARMACOKINETICS_
Thiamine: It is widely distributed to most body tissues and appears in
breast milk. Thiamine is not stored to any appreciable extent in the
body and amounts in excess of the body's requirements
are excreted in the urine.
Pyridoxine: They stored mainly in the liver and excreted in the urine,
Pyridoxal crosses the placenta and appears in breast milk.
Cyanocobalamin: It is bound to specific plasma proteins. They stored
in the liver excreted in the bile and urine. It diffuses across the
placenta and also in breast milk.
Mono-and polyneuropathies such as diabetic, alcoholic and toxic
neuropathies, neuritis and neuralgia, especially cervical syndrome,
shoulder-arm syndrome, lumbago, sciatica, root irritation
due to degenerative changes of the vertebral column.
Deficiency or raised requirement of Vitamin B
1
, B
6
and B
12
.
Oral
One tablet three times daily