VANCO-TEVA 1 GR

Country: Israel

Language: English

Source: Ministry of Health

Active ingredient:

VANCOMYCIN AS HYDROCHLORIDE

Available from:

TEVA PHARMACEUTICAL INDUSTRIES LTD, ISRAEL

ATC code:

A07AA09

Pharmaceutical form:

LYOPHILIZED POWDER FOR INJECTION

Composition:

VANCOMYCIN AS HYDROCHLORIDE 1 G/VIAL

Administration route:

I.V

Prescription type:

Required

Manufactured by:

TEVA PHARMACEUTICAL WORKS PRIVATE LIMITED COMPANY, HUNGARY

Therapeutic group:

VANCOMYCIN

Therapeutic area:

VANCOMYCIN

Therapeutic indications:

Vancomycin hydrochloride is indicated for the treatment of severe or serious infections due to susceptible strains of methicillin - resistant (beta-Iactam-resistant) staphylococci. It is also indicated for administration to penicillin-allergic patients as well patients who have failed to respond to or who cannot receive other drugs including cephalosporins or penicillins and for infections due to vancomycin-susceptible organisms that are resistant to other antimicrobial drugs. Vancomycin hydrochloride is indicated for first-line therapy when methicillin-resistant staphylococci are suspected but when susceptibility data become available appropriate therapy should be instituted. Vancomycin hydrochloride is effective in the treatment of staphylococcal endocarditis as well as in other infections due to staphylococci including lower respiratory tract infections septicemia skin and skin - stucture infection and bone infections. Antibiotic therapy is as an adjunct to appropriate surgical measures when sta

Authorization date:

2010-11-30

Summary of Product characteristics

"
ע עבקנ הז ןולע טמרופ
"
רשואו קדבנ ונכותו תואירבה דרשמ י
."
רשואמ ןולע
:
רבמבונ
2010
.
“This leaflet format has been determined by the Ministry of Health
and the content thereof has been
checked and approved.” Date of approval: November 2010
אפורל ןולע
Insert
Package
Physician’s
===============================================================
VANCO TEVA


וקנו
עבט
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INJECTION
דירוה ךותל הקרזהל
COMPOSITION
Each vial of lyophilizate contains:
_Active Ingredient _
Vancomycin (as hydrochloride)
500 mg or 1 g
_Other ingredients _
Sodium hydroxide, hydrochloric acid (for pH adjustment)
ACTION
Vancomycin hydrochloride, a tricyclic glycopeptide antibiotic, is
obtained from
_Nocardia orientalis _(formerly _Streptomyces orientalis_).
Vancomycin hydrochloride is bactericidal, and appears to act by
binding to the
bacterial cell wall with resultant blockage of glycopeptide
polymerization. This mode of
action differs from that of the penicillins, which produce instant
inhibition of cell wall
synthesis
and
secondary
damage
to
the
cytoplasmic
membrane.
Also, there is
evidence
that
vancomycin
hydrochloride
selectively
inhibits
RNA
synthesis
and
changes the permeability of the bacterial cell membrane.
Vancomycin hydrochloride is active against many gram-positive bacteria
such as
staphylococci,
including
_Staphylococcus_
_aureus_
and
_Staphylococcus _
_epidermidis_
(including
heterogenous
methicillin-
resistant
strains);
streptococci,
including
_Streptococcus _
_pyogenes_,
_Streptococcus _
_pneumonia_,
(including
penicillin-resistant
strains),
_Streptococcus_
_agalactiae_,
the
viridans
group,
_Streptococcus _
_bovis; _
enterococci (e.g. _ Enterococcus fecalis_ [formerly _ Streptococcus
fecalis_]); _ Clostridium _
_difficile_ (including toxigenic strains implicated in _
Pseudomembranous enterocolitis)_;
and diphtheroids. Oth