TRIDOXINE INJECTION

Country: Australia

Language: English

Source: APVMA (Australian Pesticides and Veterinary Medicines Authority)

Active ingredient:

TRIMETHOPRIM; SULFADOXINE

Available from:

JUROX PTY LIMITED

INN (International Name):

sulfadoxine(200mg/mL)+trimethoprim(40mg/mL)

Pharmaceutical form:

PARENTERAL LIQUID/SOLUTION/SUSPENSION

Composition:

TRIMETHOPRIM PYRIMIDINE Active 40.0 mg/ml; SULFADOXINE SULFANYL Active 200.0 mg/ml

Units in package:

100mL

Class:

VM - Veterinary Medicine

Therapeutic group:

CAT | CATTLE | DOG | HORSE | PIGS | SHEEP | BEEF | BITCH | BOAR | BOS INDICUS | BOS TAURUS | BOVINE | BUFFALO | BULL | BULLOCK |

Therapeutic area:

ANTIBIOTIC & RELATED

Therapeutic indications:

ACTINOMYCES SPP. | BACILLUS ANTHRACIS | BACTERIAL INFECTION | BORDETELLA SPP. | BRONCHITIS | BRUCELLA SPP. | CAMPYLOBACTER SPP. | CLOSTRIDIUM SPP. | CORYNEBACTERIUM SPP. | CYSTITIS | ESCHERICHIA COLI (E. COLI) | FUSOBACTERIUM SPP. | HAEMOPHILUS SPP. | INFECTIONS OF THE ALIMENTARY TRACT | INFECTIONS OF THE URINARY TRACTS | KLEBSIELLA SPP. | METRITIS | NEPHRITIS | PASTEURELLA SPP. | PNEUMONIA | SALMONELLA | SALMONELLA SPP. | SHIGELLA SPP. | STAPHYLOCOCCI | STREPTOCOCCI | URETHRITIS | VAGINITIS | WOUND INFECTIONS | ABSCESSES | AMOXYCILLIN SENSITIVE BACTERIA | ANAEROBIC BACTERIA | ANTHRAX | ASSOCIATED WITH VIRAL DISEASE | BACTERIAL CANKER | BACTERIAL PNEUMONIA | BORDETELLA BRONCHISEPTICA | BRUCELLA ABORTUS | BRUCELLA MELITENSIS | BRUCELLA SUIS | CLOSTRIDIUM BOTULINUM | CLOSTRIDIUM CHAUVOEI | CLOSTRIDIUM FALLAX | CLOSTRIDIUM FESERI | CLOSTRIDIUM HEMOLYTICUM | CLOSTRIDIUM NOVYI | CLOSTRIDIUM PERFRINGENS TYPES | CLOSTRIDIUM SEPTICUM | CLOSTRIDIUM SORDELLI | CLOSTRIDIUM SPOROGENES | CLOSTRIDIUM TETANI | ESCHERICHIA

Product summary:

Poison schedule: 4; Withholding period: WHP: Meat: DO NOT USE less than 14 days (cattle sheep pigs) 28 days (horses) before slaughter for human consumption . Milk: Milk collected from animals wi thin 36 hours (3 milkings) following a single treatment or 3 days following th e last of multiple treatments MUST NOT BE USED for human consumption or proce ssing or fed to bobby calves.; Host/pest details: CAT: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; CATTLE: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; DOG: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; HORSE: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; PIGS: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; SHEEP: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; Poison schedule: 4; Withholding period: ; Host/pest details: CAT: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; CATTLE: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; DOG: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; HORSE: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; PIGS: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; SHEEP: [ACTINOMYCES SPP., BACILLUS ANTHRACIS, BACTERIAL INFECTION, BORDETELLA SPP., BRONCHITIS, BRUCELLA SPP., CAMPYLOBACTER SPP., CLOSTRIDIUM SPP., CORYNEBACTERIUM SPP., CYSTITIS, ESCHERICHIA COLI (E. COLI), FUSOBACTERIUM SPP., HAEMOPHILUS SPP., INFECTIONS OF THE ALIMENTARY TRACT, INFECTIONS OF THE URINARY TRACTS, KLEBSIELLA SPP., METRITIS, NEPHRITIS, PASTEURELLA SPP., PNEUMONIA, SALMONELLA, SALMONELLA SPP., SHIGELLA SPP., STAPHYLOCOCCI, STREPTOCOCCI, URETHRITIS, VAGINITIS, WOUND INFECTIONS]; For the treatment of infections caused by organisms sensitive to trimethoprim and sulfadoxine in cattle, sheep, pigs, horses, cats and dogs.Contraindicated prior to and after treatment with sedatives and anaesthetics in the recumbent horse

Authorization status:

Registered

Authorization date:

2023-07-01

Patient Information leaflet

Australian Government
Australian Pesticides
and
Veterinary Medicines Authority
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Approved
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Signal
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Product
name:
Active constituentfs:
Statement
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claims:
Net contents:
Directions for Use
PRESCRIPTION ANIMAL REMEDY
KEEP
OUT
OF
REACH
OF
CHILDREN
FOR ANIMAL TREATMENT ONLY
TRIDOXINE Injection
200
mglmL Sulfadoxine
40 mglmL Trimethoprim
For the treatment
of
infections caused by organisms sensitive
to
trimethoprim
and sulfadoxine in cattle, sheep, pigs, horses, cats and dogs.
Tridoxine Injection contains
40
mglmL trimethoprim, a synthetic antibacterial,
and
200
mglmL sulfadoxine a long -
acting sulfonamide. Tridoxine is effective
against
most
Gram-positive and Gram negative bacteria. The
two
components
of
Tridoxine
Injection
produce
a
sequential
double
blockade
of
bacterial
metabolism giving a level
of
activity many times greater than that obtained from
either drug alone.
INDICATIONS
Tridoxine Injection
is
indicated
for
the
systemic treatment of:
Respiratory infections
of
bacterial origin including pneumonia, bronchitis and
secondary bacterial infection following
virus
pneumonia.
Urogenital
tract
infections including cystitis, vaginitis, urethritis, nephritis and
metritis.
Alimentary
tract
infections including
E.coli
infections and salmonellosis.
Post-operative and past-parturient uses, wound infections and
septicaemias.
Trfdoxine Injection is active
in vitro
against Gram-positive and Gram-negative
organisms including
Actinomyces
spp,
Bacillus anthrac!s,
Bordetella
spp.,
Brucella
spp.,
Clostridium
spp.,
Corynebacterium
spp.,
Escherichia
COLI,
Haemophi/us
spp.,
Klebsiella
spp.,
Shigella spp., Staphylococci, Streptococci,
Pasteurella
spp.,
Salmonella
spp.,
Fusobacterium
spp., and
Campylobacter
spp.
Note:
Erysipelothrix, Leptospira
and
Pseudomonas
organisms are
not