Triasyn

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Ramipril; Felodipine

Available from:

Sanofi-Aventis Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

TRIASYN
®

(TRY-A(H)-SIN)
_Ramipril and felodipine (ram-(m)e-pril (and) fell-odd-ip-een)_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Triasyn.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking this medicine
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT TRIASYN IS USED
FOR
Triasyn contains two types of
medicine. These are an angiotensin
converting enzyme (ACE) inhibitor
and a calcium channel blocker.
Triasyn is used to lower high blood
pressure (hypertension). Everyone
has blood pressure. This pressure
helps get your blood all around your
body. Your blood pressure may be
different at different times of the day
and can be influenced by how busy
or worried you are. You have
hypertension when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated, it can
lead to serious health problems,
including stroke, heart disease and
kidney failure.
Triasyn works by widening the blood
vessels, which reduces the pressure
in the vessels, making it easier for
your heart to pump blood around
your body.
ASK YOUR DOCTOR OR PHARMACIST IF
YOU HAVE ANY QUESTIONS ABOUT WHY
IT HAS BEEN PRESCRIBED FOR YOU.
Triasyn is only available with a
doctor's prescription.
Triasyn is not addictive.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE TRIASYN IF YOU:
•
ARE ALLERGIC TO TRIASYN OR ANY
OTHER MEDICINE CONTAINING
RAMIPRIL OR FELODIPINE, OR ANY OF
THE INGREDIENTS LISTED AT THE END
OF THIS LEAFLET.
 Symptoms of an alle

Summary of Product characteristics

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PRODUCT INFORMATION 
TRIASYN


NAME OF THE MEDICINE 
NON-PROPRIETARY NAME 
Ramipril and felodipine 

Felodipine structural formula: 

Ramipril structural formula: 

DESCRIPTION 
Felodipine is a racemic mixture of ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro 2,6-dimethyl-3,5 
pyridine dicarboxylate.  It is a slightly yellowish crystalline powder with
a melting point between 142 
and  145
o
C.    Felodipine  is  freely  soluble  in  ethanol,  acetone  and  dichloromethane,  but  practically 
insoluble in water at 37
o
C.  It is moderately light sensitive and has a molecular weight of 384.26.  
The empirical formula is C
18
H
19
Cl
2
NO
4
.  CAS registry number is 72509-76-3. 
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative.  It is a white to almost white 
crystalline  powder  with  a  melting  point  between  105
o
C  and  112
o
C.    Ramipril  is  freely  soluble  in 
polar organic solvents and buffered aqueous solutions.  It is slightly soluble in water.  Ramipril has 
a  molecular  weight  of  416.52  and  an  empirical  formula  of  C
23
H
32
N
2
O
5
.    Its  chemical  name  is 
(2S,3aS,6aS)-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-
carboxylic acid,1-ethyl ester.  CAS registry number is 87333-19-5. 
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Triasyn  tablets  are  circular,  biconvex,  film-coated,  two-layered  tablets,  with  felodipine  in  an 
extended-release  gel  matrix  formulation  in  one  layer  and  rapidly  dissolving  ramipril  in  the  other 
layer. 
The  excipients  contained  in  Triasyn  tablets  are  aluminium  sodium  silicate,  microcrystalline 
cellulose,  hydroxypropylcellul