Three Legs Glucosamine Sulphate 500mg Capsule

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

glucosamine sulphate

Available from:

SYARIKAT WEN KEN DRUG SDN. BHD.

INN (International Name):

glucosamine sulphate

Units in package:

60 Capsules; 120 Capsules; 180 Capsules; 500 Capsules; 1000 Capsules; 60 Capsules; 100 Capsules; 120 Capsules; 180 Capsules; 300 Capsules; 500 Capsules; 1000 Capsules

Manufactured by:

SYARIKAT WEN KEN DRUG SDN. BHD.

Summary of Product characteristics

THREE LEGS GLUCOSAMINE SULPHATE 500MG
CAPSULE
COMPOSITION:
Each capsule 628mg contains:
Glucosamine Sulphate Sodium Chloride 628mg (equivalent to
Glucosamine Sulphate 500mg)
PRODUCT DESCRIPTION: White colour powder is filled in scarlet bovine
capsule. Capsule size: 0.
No marking on the capsule.
PHARMACODYNAMICS:
Glucosamine is a natural substance found in chitin, mucoproteins and
mucopolysaccharides. It is involved in the manufacture of
glycosaminoglycan, which forms
cartilage tissue in the body; glucosamine is also present in tendons
and ligaments.
Glucosamine must be synthesized by the body but the ability to do this
declines with age.
Glucusamine and its salts have therefore been advocated in the
treatment of rheumatic
disorders including osteoarthritis.
Glucosamine also acts to improve the viscosity of synovial fluid by
increasing synovial fluid
production, thereby providing lubricant activity.
PHARMACOKINETICS:
_Absorption_
After oral administration, bioavailability is low due to first-pass
hepatic metabolism ~26%. The
gastrointestinal absorption is close to 90%.
_Distribution_
Glucosamine is not protein-bound, but rather incorporates into plasma
proteins (primarily
globulins)
Volume of Distribution: 2.5 Liters
_Metabolism_
- Liver, extensive
The first-pass effect in the liver in which more than 70% of
glucosamine is metabolized.
_Excretion_
Renal Excretion, 10%
Feces, 11%
Part of a dose of glucosamine sulfate is eliminated as carbon dioxide
via expired air.
INDICATION: As adjuvant therapy for osteoarthritis.
DIRECTION OF USE:
Best to be taken on an empty stomach (30 minutes before meals).
Light or moderate osteoarthritis symptoms:
1 capsule to be taken 2 times daily for at least 6 weeks or according
to medical
prescription.
Severe osteoarthritis symptoms:
Initial therapy: 1 capsule to be taken 3 times daily is recommended
for at least 8 weeks.
Follow-up therapy:
Maintenance therapy should be followed for 3-4 months (or according to
medical
prescription) by administration of 1 capsule twice daily.
The treatm