Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
candesartan cilexetil,hydrochlorothiazide
Apotex Pty Ltd
Candesartan cilexetil,Hydrochlorothiazide
Registered
TERRY WHITE CHEMISTS CANDESARTAN HCTZ TABLETS _Contains the active ingredient candesartan cilexetil and hydrochlorothiazide_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about candesartan cilexetil and hydrochlorothiazide (HCTZ). It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. Ask your doctor or pharmacist: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Terry White Chemists Candesartan HCTZ tablets. It contains the active ingredients candesartan cilexetil and hydrochlorothiazide. It is used to treat: • high blood pressure, also called hypertension. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Candesartan cilexetil is a type of medicine called an angiotensin II receptor inhibitor (or antagonist). It mainly works by causing relaxation of blood vessels. Hydrochlorothiazide is a type of medicine called a diuretic. It works by reducing the amount of excess fluid in the body. Using these two medicines together will lower your blood pressure more effectively than using either on Read the complete document
Product Information – Australia Terry White Chemists Candesartan HCTZ Tablets Page 1 TERRY WHITE CHEMISTS CANDESARTAN HCTZ TABLETS NAME OF THE MEDICINE Candesartan cilexetil and hydrochlorothiazide CANDESARTAN Chemical Name: (±)-1-(cyclohexyloxycarbonyl-oxy) ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl]-1H-benzimadozole-7-carboxylate Structural Formula: Molecular Formula: C 33 H 34 N 6 O 6 Molecular Weight: 610.67 CAS Registry Number: 145040-37-5 HYDROCHLOROTHIAZIDE Chemical Name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide 1, 1-dioxide. Structural Formula: Molecular Formula: C 7 H 8 N 3 S 2 O 4 Cl Molecular Weight: 297.75 CAS Registry Number: 58-93-5 DESCRIPTION Candesartan is a white to off white powder and is practically insoluble in water. Hydrochlorothiazide is a sulfonamide derived drug. It is a white, or almost white crystalline powder and is very slightly soluble in water. Product Information – Australia Terry White Chemists Candesartan HCTZ Tablets Page 2 Each tablet contains 16 mg or 32 mg candesartan cilexetil and 12.5 mg or 25 hydrochlorothiazide as the active ingredient. In addition, each tablet contains the following inactive ingredients lactose, carmellose calcium, starch – maize, macrogol 8000, hydroxypropylcellulose, magnesium stearate, Pigment Blend PB-24880 Pink ( 16/12.5 mg and 32/25 mg tablets only) and iron oxide yellow in the 32/12.5 mg tablets only. The tablets are gluten free. PHARMACOLOGY PHARMACOLOGICAL ACTIONS Angiotensin II is the primary vasoactive hormone of the renin-angiotensin-aldosterone system and plays a significant role in the pathophysiology of hypertension and other cardiovascular disorders. It also has an important role in the pathogenesis of end organ hypertrophy and damage. The major physiological effects of angiotensin II, such as vasoconstriction, aldosterone stimulation, regulation of salt and water homeostasis and stimulation of cell growth, are mediated via the type 1 (AT1) receptor. Candesartan cilexetil is a prodrug sui Read the complete document