TERGIVE 30

Country: Australia

Language: English

Source: APVMA (Australian Pesticides and Veterinary Medicines Authority)

Active ingredient:

CARPROFEN

Available from:

PARNELL TECHNOLOGIES PTY LTD

INN (International Name):

carprofen(30mg/mL)

Pharmaceutical form:

ORAL SYRUP

Composition:

CARPROFEN ANTI-INFLAMMATORY-NONSTEROIDAL Active 30.0 mg/ml

Units in package:

100mL; 25mL

Class:

VM - Veterinary Medicine

Manufactured by:

PARNELL TECHNOLOGIES

Therapeutic group:

DOG | BITCH | CASTRATE | PUPPY

Therapeutic area:

MUSCULOSKELETAL SYSTEM

Therapeutic indications:

ANTI-INFLAMMATORY AGENT | ANTIPYRETIC | BONE SORENESS | BRUISING | BURSITIS | INFLAMMATORY RHEUMATIC ARTHRIT | JOINT DISEASE | LIGAMENT SPRAINS | MUSCLE SORENESS | OSTEOARTHRITIS | PLATELET ACTIVITY | RHEUMATISM | SPRAINS | STRAINS | TENDON SPRAINS | TRAUMATIC SWELLING

Product summary:

Poison schedule: 4; Withholding period: WHP: N/A; Host/pest details: DOG: [ANTI-INFLAMMATORY AGENT]; Poison schedule: 4; Withholding period: ; Host/pest details: DOG: [ANTI-INFLAMMATORY AGENT]; A non-steroid antiinflammatory drug for the relief of pain and inflammation in dogs.The use of this product in cats is contraindicated. See Label for other PRECAUTIONS, etc.

Authorization status:

Registered

Authorization date:

2023-07-01

Patient Information leaflet

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PRESCRIPTION ANIMAL REMEDY
KEEP OUT OF REACH OF CHILDREN
FOR ANIMAL TREATMENT ONLY
TERGIVE 10
TERGIVE 30
ACTIVE CONSTITUENT
CARPROFEN 10mg/mL & 30mg/mL
A non-steroidal antiinflammatory drug for the
relief of pain and inflammation in dogs.
PHARMACOLOGY
Carprofen is a non-steroidal antiinflammatory drug (NSAID) of
the propionic acid class with antiinflammatory, antipyretic and
analgesic activity. The mechanism of action of carprofen is not
completely understood. As for other NSAIDs, carprofen is known
to inhibit cyclooxygenase (COX), the enzyme responsible for the
conversion of arachidonic acid into pro-inflammatory mediators.
However carprofen is a relatively weak inhibitor of COX at
therapeutic dose rates, suggesting other mechanisms may be at
least
partly
responsible
for
its
antiinflammatory
activity.
Carprofen has some inhibitory activity against phospholipase A
2
,
although the clinical significance of this activity is uncertain.
A
mode
of
action
not
primarily
involving
inhibition
of
prostaglandin production may account for the improved safety
profile of carprofen over other NSAIDs of the same class in terms
of lower ulcerogenic potential in the gastrointestinal tract.
Carprofen is rapidly and extensively absorbed following oral
administration; bioavailability is greater than 90%. Carprofen
has a low volume of distribution and, as for many NSAIDs, has a
high level of plasma protein binding at greater than 98%.
Carprofen metabolism in the dog occurs via glucuronidation and
oxidative processes in the liver. Excretion of the metabolites
occurs
primarily
(70-80%)
via
the
faeces,
with
10-20%
eliminated in the urine. Some enterohepatic circulation occurs.
The elimination half-life of carprofen in the dog is approximately
8 hours.
As
demonstrated
previously
for
other
NSAIDs
such
as
phenylbutazone and flunixin, carprofen has been found to persi

Summary of Product characteristics

PAGE 1 OF 2 

MATERIAL SAFETY DATA SHEET: 

1. IDENTIFICATION
OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING 
PRODUCT NAME : Tergive 10, Tergive 30_ _
OTHER NAMES :_ _Carprofen, Carprofen Oral 
RECOMMENDED USE: FOR ANIMAL TREATMENT ONLY. A non-steroidal
anti-inflammatory drug for the relief 
of pain and inflammation in dogs. 

MANUFACTURER COMPANY DETAILS: 

LICENSEE (NEW ZEALAND) DETAILS: 
Parnell Manufacturing Pty Ltd 

Parnell NZ Co 

ADDRESS      ADDRESS 
Unit 4, Century Estate   

             PO Box 73160 
476 Gardeners Road 

Auckland International Airport 
Alexandria, NSW 2015   

             Manukau 2150 
Australia      New 
Zealand 

TELEPHONE 
NUMBER 
    TELEPHONE 
NUMBER 
61 (0)2-9667 4411 

0800 446 282 (Toll free within NZ) 

EMERGENCY TELEPHONE NUMBER 

EMERGENCY TELEPHONE NUMBER 
61 (0)2-9667 4411 (Business Hours) 

0800 446 282 (Business Hours) 

FACSIMILE 
NUMBER 
    FACSIMILE 
NUMBER 
61 (0)2-9667 4139 

0800 727 533 (Toll free within NZ) 
2. HAZARDS IDENTIFICATION 
Hazardous
substance according to criteria of Worksafe Australia. 
3. COMPOSITION/INFORMATION ON INGREDIENTS 
CHEMICAL ENTITY 

CAS NUMBER   

PROPORTION 

_Tergive 10 _
_Tergive 30 _
Carprofen 

53716-49-7 
  1.0% 
w/v 3.0% 
w/v 
Other non-hazardous ingredients 
         ---  

To 100.0% 
To 100.0% 
4. FIRST AID MEASURES 
SWALLOWED:Rinse out mouth with water. Seek medical advice. 
EYE: Hold eyes open, flood with water or physiological
saline for at least 15 minutes. Seek medical assistance 
if required. 
SKIN: Wash off any product_ _contacting skin
immediately using soap and water. No specific
first aid required. 
INHALED: Seek medical assistance if requ