Country: Canada
Language: English
Source: Health Canada
SODIUM BICARBONATE
PFIZER CANADA ULC
B05XA02
SODIUM BICARBONATE
42MG
SOLUTION
SODIUM BICARBONATE 42MG
INTRAVENOUS
10ML
Ethical
ALKALINIZING AGENTS
Active ingredient group (AIG) number: 0104153008; AHFS:
APPROVED
2004-04-23
PRESCRIBING INFORMATION SODIUM BICARBONATE INJECTION USP 42 MG/ML (4.2%), 75 MG/ML (7.5%), 84 MG/ML (8.4%) STERILE SOLUTION Lifeshield ® ABBOJECT ® Single-dose Syringes, ABBOJECT ® Single-dose Syringes and Fliptop Vial ALKALIZER _FOR CORRECTION OF METABOLIC ACIDOSIS AND OTHER CONDITIONS REQUIRING _ _SYSTEMIC ALKALINIZATION_ Pfizer Canada ULC 17300 Trans-Canada Highway Kirkland, Québec H9J 2M5 Control Number: 263184 DATE OF REVISION: AUG 19, 2022 2 PRESCRIBING INFORMATION SODIUM BICARBONATE INJECTION USP 42 MG/ML (4.2%), 75 MG/ML (7.5%), 84 MG/ML (8.4%) STERILE SOLUTION Lifeshield ® ABBOJECT ® Single-dose Syringes and ABBOJECT ® Single-dose Syringes and Fliptop Vial ALKALIZER _FOR CORRECTION OF METABOLIC ACIDOSIS AND OTHER CONDITIONS REQUIRING _ _SYSTEMIC ALKALINIZATION_ ACTION AND CLINICAL PHARMACOLOGY Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis. Sodium bicarbonate in water dissociates to provide sodium (Na + ) and bicarbonate (HCO 3 - ) ions. Sodium (Na + ) is the principal cation of extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Bicarbonate (HCO 3 - ) is a normal constituent of body fluids and the normal plasma level ranges from 24 to 31 mmol (mEq)/liter. Plasma concentration is regulated by the kidney through acidification of the urine when there is a deficit or by alkalinization of the urine when there is an excess. Bicarbonate anion is considered "labile" since at a proper concentration of hydrogen ion (H + ) it may be converted to carbonic acid (H 2 CO 3 ) and thence to its volatile form, carbon dioxide (CO 2 ) excreted by the lung. Normally a ratio of 1:20 (carbonic acid: bicarbonate) is present in the extracellular fluid. In a healthy adult with normal kidney function, practically all the glomerular filtered bicarbonate ion is reabsorbed: less than 1% is excreted in the urine. INDICATIONS AND CLINICAL USE Sodium Bi Read the complete document