SEVOFLURANE liquid

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

Sevoflurane (UNII: 38LVP0K73A) (Sevoflurane - UNII:38LVP0K73A)

Available from:

Butler Animal Health Supply, LLC

Administration route:

RESPIRATORY (INHALATION)

Prescription type:

PRESCRIPTION

Therapeutic indications:

Sevoflurane is indicated for induction and maintenance of general anesthesia in dogs. Sevoflurane is contraindicated in dogs with a known sensitivity to sevoflurane or other halogenated agents.

Product summary:

Sevoflurane is packaged in 250 mL amber-colored bottles. 250 ML - NDC 11695-0505-2 STORAGE CONDITIONS: Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [See USP Controlled Room Temperature].

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

SEVOFLURANE - SEVOFLURANE LIQUID
BUTLER ANIMAL HEALTH SUPPLY, LLC
----------
SEVOFLURANE
NONFLAMMABLE, NONEXPLOSIVE
INHALATION ANESTHETIC FOR USE IN DOGS
SPL UNCLASSIFIED SECTION
CAUTION: FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON THE ORDER OF
A
LICENSED VETERINARIAN.
DESCRIPTION
Sevoflurane is a volatile liquid, is a halogenated general inhalation
anesthetic drug. Its
chemical name is fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)
ethyl ether, and its
structural formula is:
Sevoflurane Physical Constants are:
Molecular Weight 200.05
Boiling Point at 760 mm Hg 58.6°C
Specific Gravity at 20°C 1.520-1.525 g/mL
Vapor Pressure in mm Hg at 20°C 157
at 25°C 197
at 36°C 317
Distribution Partition Coefficients at 37°C:
Blood/Gas 0.63-0.69
Water/Gas 0.36
Olive Oil/Gas 47-54
Brain/Gas 1.15
Mean Component/Gas Partition Coefficients at 25°C for Polymers Used
Commonly in
Medical Applications:
Conductive rubber 14.0
Butyl rubber 7.7
Polyvinyl chloride 17.4
Polyethylene 1.3
Sevoflurane is nonflammable and nonexplosive as defined by the
requirements of
International Electrotechnical Commission 601-2-13.
Sevoflurane is a clear, colorless, stable liquid containing no
additives or chemical
stabilizers. Sevoflurane is nonpungent. It is miscible with ethanol,
ether, chloroform and
petroleum benzene, and it is slightly soluble in water. Sevoflurane is
stable when stored
under normal room lighting condition according to instructions.
INDICATIONS
Sevoflurane is indicated for induction and maintenance of general
anesthesia in dogs.
DOSAGE AND ADMINISTRATION
INSPIRED CONCENTRATION: The delivered concentration of sevoflurane
should be known.
Since the depth of anesthesia may be altered easily and rapidly, only
vaporizers
producing predictable percentage concentrations of sevoflurane should
be used.
Sevoflurane should be vaporized using a precision vaporizer
specifically calibrated for
sevoflurane. Sevoflurane contains no stabilizer. Nothing in the drug
product alters
calibration or operation of these vaporizers. The administr