Sevikar HCT

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Amlodipine besilate; Hydrochlorothiazide; Olmesartan medoxomil

Available from:

Merck Sharp & Dohme Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

SEVIKAR
®
 HCT

_Olmesartan medoxomil, amlodipine (as besilate) and
hydrochlorothiazide_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about SEVIKAR HCT. It
does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking SEVIKAR
HCT against the benefits they expect
it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT SEVIKAR HCT IS
USED FOR
SEVIKAR HCT is used to treat high
blood pressure which is sometimes
called hypertension.
Everyone has blood pressure. This
pressure helps push blood all around
your body. Your blood pressure
changes at different times of the day,
depending on how busy or worried
you are. You have hypertension (high
blood pressure) when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems,
including stroke, heart disease and
kidney failure.
_HOW SEVIKAR HCT WORKS_
SEVIKAR HCT contains olmesartan
medoxomil, which belongs to a
group of medicines known as
angiotensin-II receptor antagonists.
Angiotensin-II is a substance
produced in the body which causes
blood vessels to tighten. SEVIKAR
HCT blocks the action of
angiotensin-II and therefore relaxes
your blood vessels. This helps lower
your blood pressure.
SEVIKAR HCT also contains
amlodipine besilate, a calcium
channel blocker. This reduces the
movement of calcium into the cells
of the heart and blood vessels. This
also helps to lower blood pressure as
it relaxes the blood vessels and
increases the supply of blood and
oxygen to the heart.
SEVIKAR HCT also cont

Summary of Product characteristics

SEVIKAR HCT PI v1.0 A130920 CCDS ref v4.0 130701 
Page 1 
PRODUCT INFORMATION 

SEVIKAR
® 
HCT FILM COATED TABLETS 
(olmesartan medoxomil/amlodipine (as besilate) and
hydrochlorothiazide) 
SEVIKAR HCT 20/5/12.5 
SEVIKAR HCT 40/5/12.5 
SEVIKAR HCT 40/5/25 
SEVIKAR HCT 40/10/12.5 
SEVIKAR HCT 40/10/25 

NAME OF THE MEDICINE 
OLMESARTAN MEDOXOMIL is chemically described as

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 
4-(1-hydroxy-1-methylethyl)-2-propyl-1-[ [2 '-(1_H_-tetrazol-5-yl)
biphenyl-4-yl] methyl] -1_H_-
imidazole-5-carboxylate. The empirical formula is C
29
H
30
N
6
O
6
 and its molecular weight is 
558.6. Its CAS number is 144689-63-4.  Its structural
formula is: 

AMLODIPINE BESILATE is a racemic mixture and
is chemically described as 3-Ethyl 5-methyl 
(4_RS_)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-
dicarboxylate benzenesulfonate. The empirical formula is C
20
H
25
CIN
2
O
5
•C
6
H
6
O
3
S and its 
molecular weight is 567.1. The CAS number is 111470-99-6 and its
structural formula is: 

HYDROCHLOROTHIAZIDE is
described chemically as 6-chloro-3,4-dihydro-2_H_-1,2,4-
benzothiadiazine-7-sulfonamide 1,1-dioxide. The empirical
formula is C
7
H
8
ClN
3
O
4
S
2 
and its 
molecular weight is 297.7
. 
 Its CAS no. is 58-93-5. The structural formula is: 

SEVIKAR HCT PI v1.0 A130920 CCDS ref v4.0 130701 
Page 2 
DESCRIPTION 
OLMESARTAN MEDOXOMIL is a white or almost
white crystalline powder. It is practically 
insoluble in water and slightly soluble in ethanol (96 per cent),
practically insoluble in 
heptane. The pH of a solution (2% w/v) of olmesartan
medoxomil in water is 5.6. The 
dissociation constant (pKa) is 4.3. The partition
coefficient Log P is 1.0 at pH 7.0. 

AMLODIPINE BESILATE is a white or almost white powder,
slightly soluble in water and freely 
soluble in methanol, s