SENTINEL SPECTRUM- milbemycin oxime, lufenuron and praziquantel tablet, chewable

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

MILBEMYCIN OXIME (UNII: 0502PUN0GT) (MILBEMYCIN OXIME - UNII:0502PUN0GT), LUFENURON (UNII: 1R754M4918) (LUFENURON - UNII:1R754M4918), PRAZIQUANTEL (UNII: 6490C9U457) (PRAZIQUANTEL - UNII:6490C9U457)

Available from:

Merck Sharp & Dohme Corp.

Administration route:

ORAL

Prescription type:

PRESCRIPTION

Therapeutic indications:

Indications: SENTINEL SPECTRUM Chews are indicated for the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations (Ctenocephalides felis ); and for the treatment and control of adult roundworm (Toxocara canis , Toxascaris leonina ), adult hookworm (Ancylostoma caninum ), adult whipworm (Trichuris vulpis ), and adult tapeworm (Dipylidium caninum, Taenia pisiformis , Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older. Contraindications: There are no known contraindications to the use of SENTINEL SPECTRUM Chews.

Product summary:

How Supplied: SENTINEL SPECTRUM Chews are available in four strengths, formulated according to the weight of the dog. Each strength is available in color-coded packages of six chewable tablets each.

Authorization status:

New Animal Drug Application

Summary of Product characteristics

SENTINEL SPECTRUM- MILBEMYCIN OXIME, LUFENURON AND PRAZIQUANTEL
TABLET,
CHEWABLE
MERCK SHARP & DOHME CORP.
----------
SENTINEL
SPECTRUM CHEWS
(MILBEMYCIN OXIME • LUFENURON • PRAZIQUANTEL)
MERCK
Animal Health
CAUTION: Federal (USA) law restricts this drug to use by or on the
order of a licensed
veterinarian.
DESCRIPTION: SENTINEL
SPECTRUM Chews are available in four strengths in color-
coded packages for oral administration to dogs and puppies according
to their weight.
Each chewable flavored tablet is formulated to provide a minimum of
0.23 mg/pound
(0.5mg/kg) of milbemycin oxime, 4.55 mg/pound (10mg/kg) of lufenuron,
and 2.28
mg/pound (5mg/kg) of praziquantel.
Milbemycin oxime consists of the oxime derivatives of
5-didehydromilbemycins in the
ratio of approximately 80% A (C
H
NO , MW 555.71) and 20% A (C
H
NO , MW
541.68). Milbemycin oxime is classified as a macrocyclic anthelmintic.
Lufenuron is a benzoylphenylurea derivative with the following
chemical composition: N-
[2,5-dichloro-4-(1,1,2,3,3,3,-hexafluoropropoxy)-phenyl-aminocarbonyl]-2,6-
difluorobenzamide (C
H CI
F N O , MW 511.15). Benzoylphenylurea compounds,
including lufenuron, are classified as insect development inhibitors
(IDIs).
Praziquantel is an isoquinolone anthelmintic with the chemical name 2-
(Cyclohexylcarbonyl)-1,2,3,6,7,-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one.
INDICATIONS: SENTINEL SPECTRUM Chews are indicated for the prevention
of
heartworm disease caused by _Dirofilaria immitis_; for the prevention
and control of flea
populations (_Ctenocephalides felis_); and for the treatment and
control of adult
roundworm (_Toxocara canis_, _Toxascaris leonina_), adult hookworm
(_Ancylostoma_
_caninum_), adult whipworm (_Trichuris vulpis_), and adult tapeworm
(_Dipylidium caninum,_
_Taenia pisiformis_, _Echinococcus multilocularis_ and _Echinococcus
granulosus_) infections in
dogs and puppies two pounds of body weight or greater and six weeks of
age and
older.
DOSAGE AND ADMINISTRATION: SENTINEL SPECTRUM Chews should be
administerd
ora