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pfizer laboratories div pfizer inc - palbociclib (unii: g9zf61le7g) (palbociclib - unii:g9zf61le7g) - palbociclib 75 mg - ibrance is indicated for the treatment of adult patients with hormone receptor (hr)-positive, human epidermal growth factor receptor 2 (her2)-negative advanced or metastatic breast cancer in combination with: none. risk summary based on findings from animal studies and its mechanism of action, ibrance can cause fetal harm when administered to a pregnant woman [see clinical pharmacology (12.1)] . there are no available data in pregnant women to inform the drug-associated risk. in animal reproduction studies, administration of palbociclib to pregnant rats and rabbits during organogenesis resulted in embryo-fetal toxicity at maternal exposures that were ≥4 times the human clinical exposure based on auc [see data] . advise pregnant women of the potential risk to a fetus. the estimated background risk of major birth defects and miscarriage for the indicated population is unknown. in the u.s. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2%–4% and 15%–20%, respectively. data animal data in a fertility and early embryonic development study in female rats, palbociclib was administered orally for 15 days before mating through to day 7 of pregnancy, which did not cause embryo toxicity at doses up to 300 mg/kg/day with maternal systemic exposures approximately 4 times the human exposure (auc) at the recommended dose. in embryo-fetal development studies in rats and rabbits, pregnant animals received oral doses of palbociclib up to 300 mg/kg/day and 20 mg/kg/day, respectively, during the period of organogenesis. the maternally toxic dose of 300 mg/kg/day was fetotoxic in rats, resulting in reduced fetal body weights. at doses ≥100 mg/kg/day in rats, there was an increased incidence of a skeletal variation (increased incidence of a rib present at the seventh cervical vertebra). at the maternally toxic dose of 20 mg/kg/day in rabbits, there was an increased incidence of skeletal variations, including small phalanges in the forelimb. at 300 mg/kg/day in rats and 20 mg/kg/day in rabbits, the maternal systemic exposures were approximately 4 and 9 times the human exposure (auc) at the recommended dose, respectively. cdk4/6 double knockout mice have been reported to die in late stages of fetal development (gestation day 14.5 until birth) due to severe anemia. however, knockout mouse data may not be predictive of effects in humans due to differences in degree of target inhibition. risk summary there is no information regarding the presence of palbociclib in human milk, its effects on milk production, or the breastfed infant. because of the potential for serious adverse reactions in breastfed infants from ibrance, advise a lactating woman not to breastfeed during treatment with ibrance and for 3 weeks after the last dose. pregnancy testing based on animal studies, ibrance can cause fetal harm when administered to a pregnant woman [see use in specific populations (8.1)]. females of reproductive potential should have a pregnancy test prior to starting treatment with ibrance. contraception females ibrance can cause fetal harm when administered to a pregnant woman [see use in specific populations (8.1)] . advise females of reproductive potential to use effective contraception during treatment with ibrance and for at least 3 weeks after the last dose. males because of the potential for genotoxicity, advise male patients with female partners of reproductive potential to use effective contraception during treatment with ibrance and for 3 months after the last dose [see nonclinical toxicology (13.1)] . infertility males based on animal studies, ibrance may impair fertility in males of reproductive potential [see nonclinical toxicology (13.1)] . the safety and efficacy of ibrance in pediatric patients have not been studied. altered glucose metabolism (glycosuria, hyperglycemia, decreased insulin) associated with changes in the pancreas (islet cell vacuolation), eye (cataracts, lens degeneration), kidney (tubule vacuolation, chronic progressive nephropathy) and adipose tissue (atrophy) were identified in a 27 week repeat-dose toxicology study in rats that were immature at the beginning of the studies and were most prevalent in males at oral palbociclib doses ≥30 mg/kg/day (approximately 11 times the adult human exposure [auc] at the recommended dose). some of these findings (glycosuria/hyperglycemia, pancreatic islet cell vacuolation, and kidney tubule vacuolation) were present with lower incidence and severity in a 15 week repeat-dose toxicology study in immature rats. altered glucose metabolism or associated changes in the pancreas, eye, kidney and adipose tissue were not identified in a 27-week repeat-dose toxicology study in rats that were mature at the beginning of the study and in dogs in repeat-dose toxicology studies up to 39 weeks duration. toxicities in teeth independent of altered glucose metabolism were observed in rats. administration of 100 mg/kg palbociclib for 27 weeks (approximately 15 times the adult human exposure [auc] at the recommended dose) resulted in abnormalities in growing incisor teeth (discolored, ameloblast degeneration/necrosis, mononuclear cell infiltrate). other toxicities of potential concern to pediatric patients have not been evaluated in juvenile animals. of 444 patients who received ibrance in paloma-2, 181 patients (41%) were ≥65 years of age and 48 patients (11%) were ≥75 years of age. of 347 patients who received ibrance in paloma-3, 86 patients (25%) were ≥65 years of age and 27 patients (8%) were ≥75 years of age. no overall differences in safety or effectiveness of ibrance were observed between these patients and younger patients. no dose adjustment is required in patients with mild or moderate hepatic impairment (child-pugh classes a and b). for patients with severe hepatic impairment (child-pugh class c), the recommended dose of ibrance is 75 mg once daily for 21 consecutive days followed by 7 days off treatment to comprise a complete cycle of 28 days [see dosage and administration (2.2)] . based on a pharmacokinetic trial in subjects with varying degrees of hepatic function, the palbociclib unbound exposure (unbound aucinf ) decreased by 17% in subjects with mild hepatic impairment (child-pugh class a), and increased by 34% and 77% in subjects with moderate (child-pugh class b) and severe (child-pugh class c) hepatic impairment, respectively, relative to subjects with normal hepatic function. peak palbociclib unbound exposure (unbound cmax ) increased by 7%, 38% and 72% for mild, moderate and severe hepatic impairment, respectively, relative to subjects with normal hepatic function [see clinical pharmacology (12.3)] . review the full prescribing information for the aromatase inhibitor or fulvestrant for dose modifications related to hepatic impairment. no dose adjustment is required in patients with mild, moderate, or severe renal impairment (crcl >15 ml/min). based on a pharmacokinetic trial in subjects with varying degrees of renal function, the total palbociclib exposure (aucinf ) increased by 39%, 42%, and 31% with mild (60 ml/min ≤ crcl <90 ml/min), moderate (30 ml/min ≤ crcl <60 ml/min), and severe (crcl <30 ml/min) renal impairment, respectively, relative to subjects with normal renal function. peak palbociclib exposure (cmax ) increased by 17%, 12%, and 15% for mild, moderate, and severe renal impairment, respectively, relative to subjects with normal renal function. the pharmacokinetics of palbociclib have not been studied in patients requiring hemodialysis [see clinical pharmacology (12.3)] .

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amorepacific corporation - ethylhexyl methoxycinnamate 7% titanium dioxide 4.15% zinc oxid 9.8% - sunscreen - helps prevent sunburn - if used as directed with other sun protection measures (see directions ), decreases the risk of skin cancer and early skin aging caused by the sun

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west-ward pharmaceuticals corp. - galantamine hydrobromide (unii: mj4ptd2vvw) (galantamine - unii:0d3q044kca) - galantamine 4 mg - galantamine is indicated for the treatment of mild to moderate dementia of the alzheimer’s type. galantamine is contraindicated in patients with known hypersensitivity to galantamine hydrobromide or to any excipients used in the formulation. pregnancy category c there are no adequate and well-controlled studies in pregnant women. in studies conducted in animals, administration of galantamine during pregnancy resulted in developmental toxicity (increased incidence of morphological abnormalities and decreased growth in offspring) at doses similar to or greater than those used clinically. galantamine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. in rats, administration of galantamine (oral doses of 2 mg, 8 mg, or 16 mg/kg/day), from day 14 (females) or day 60 (males) prior to mating and continuing in females through the period of organogenesis, resulted in an increased incidence of fetal skeletal variations at the two highest doses. the no-effect dose fo

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par pharmaceutical - methylphenidate hydrochloride (unii: 4b3sc438hi) (methylphenidate - unii:207zz9qz49) - methylphenidate hydrochloride 5 mg - attention deficit disorders (previously known as minimal brain dysfunction in children). other terms being used to describe the behavioral syndrome below include: hyperkinetic child syndrome, minimal brain damage, minimal cerebral dysfunction, minor cerebral dysfunction. methylphenidate hydrochloride tablets usp are indicated as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. the diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. nonlocalizing (soft) neurological signs, learning disability, and abnormal eeg may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be war

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hikma pharmaceuticals usa inc. - everolimus (unii: 9hw64q8g6g) (everolimus - unii:9hw64q8g6g) - everolimus is indicated for the prophylaxis of organ rejection in adult patients at low-moderate immunologic risk receiving a kidney transplant [see clinical studies (14.1)] . everolimus is to be administered in combination with basiliximab induction and concurrently with reduced doses of cyclosporine and with corticosteroids. therapeutic drug monitoring (tdm) of everolimus and cyclosporine is recommended for all patients receiving these products [see dosage and administration (2.2 and 2.3)] . everolimus is indicated for the prophylaxis of allograft rejection in adult patients receiving a liver transplant. everolimus is to be administered no earlier than 30 days posttransplant concurrently in combination with reduced doses of tacrolimus and with corticosteroids [see warnings and precautions (5.5) and clinical studies (14.2)] . tdm of everolimus and tacrolimus is recommended for all patients receiving these products [see dosage and administration (2.3, 2.5)] . the safety and efficacy of everolimus has not been

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cronus pharma llc - amoxicillin (unii: 804826j2hu) (amoxicillin anhydrous - unii:9em05410q9), clavulanate potassium (unii: q42omw3at8) (clavulanic acid - unii:23521w1s24) - indications: amoxicillin and clavulanate potassium tablets are indicated in the treatment of: dogs: skin and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing staphylococcus aureus, non- β-lactamase-producing staphylococcus aureus, staphylococcus spp., streptococcus spp., and e. coli. periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. amoxicillin and clavulanate potassium tablets have been shown to be clinically effective for treating cases of canine periodontal disease. cats: skin and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing staphylococcus aureus, non- β-lactamase-producing staphylococcus aureus, staphylococcus spp., streptococcus spp., e. coli, and pasteurella spp. urinary tract infections (cystitis) due to susceptible st

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mwi animal health - amoxicillin (unii: 804826j2hu) (amoxicillin anhydrous - unii:9em05410q9), clavulanate potassium (unii: q42omw3at8) (clavulanic acid - unii:23521w1s24) - indications:  betacillin tablets are indicated in the treatment of: dogs: skin and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing staphylococcus aureus, non- β-lactamase-producing staphylococcus aureus, staphylococcus spp., streptococcus spp., and e. coli. periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. betacillin tablets have been shown to be clinically effective for treating cases of canine periodontal disease. cats: skin and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing staphylococcus aureus, non- β-lactamase-producing staphylococcus aureus, staphylococcus spp., streptococcus spp., e. coli, and pasteurella spp. urinary tract infections (cystitis) due to susceptible strains of e. coli. therapy may be initiated with betaci

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amorepacific - ethylhexyl methoxycinnamate 7% titanium dioxide 4.15% zinc oxide 9.8% -

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par pharmaceutical - dextroamphetamine sulfate (unii: jj768o327n) (dextroamphetamine - unii:tz47u051fi) - dextroamphetamine sulfate 5 mg

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ventura international ltd - octinoxate (unii: 4y5p7mud51) (octinoxate - unii:4y5p7mud51), titanium dioxide (unii: 15fix9v2jp) (titanium dioxide - unii:15fix9v2jp) - - helps prevent sunburn - higher spf gives more sunburn protection - provides moderate protection against sunburn