RAMIPRIL-LUPIN ramipril 10mg capsules blister pack

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

ramipril

Available from:

Lupin Australia Pty Limited

INN (International Name):

Ramipril

Authorization status:

Registered

Patient Information leaflet

RAMIPRIL LUPIN
CAPSULES
CONSUMER
MEDICINE
INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Ramipril Lupin. It does
not contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and benefits.
Your doctor has weighed the risk of you
taking Ramipril Lupin against the
benefits they expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT TAKING
THIS MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may want to read it again.
WHAT RAMIPRIL LUPIN IS USED FOR
This medicine is used to treat:
•
high blood pressure
(hypertension)
•
some heart conditions such as
heart failure after a heart attack
•
kidney problems in some
patients.
Ramipril Lupin is also used to reduce the
risk of cardiovascular problems and
complications in patients aged 55 years
or more with heart or blood vessel
disease, or diabetes.
It contains the active ingredient
Ramipril. Ramipril belongs to a group of
medicines called angiotensin converting
enzyme (ACE) inhibitors.
It works by widening the blood vessels,
which reduces the pressure in the
vessels, making it easier for your heart to
pump blood around your body. This
helps to increase the supply of oxygen to
your heart, so that when you place extra
demands on your heart, such as during
exercise, your heart may cope better and
you may not get short of breath as easily.
By increasing the supply of oxygen to
your heart, your heart does not have to
work as hard and it is under less stress,
which may reduce the risk of further
damage occurring to it following a heart
attack.
Ramipril also improves blood flow
through the small blood vessels found in
the kidneys, which helps the kidneys to
work more efficiently. This in turn can
help to slow down the progression of
kidney damage that might result from
having diabetes or high blood pressure.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY RAMIPRIL LUPIN
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may hav

Summary of Product characteristics

PRODUCT INFORMATION
RAMIPRIL-LUPIN CAPSULES
NAME OF THE MEDICINE
Ramipril
DESCRIPTION
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid
derivative. It is a white, crystalline
substance soluble in polar organic solvents and buffered aqueous
solutions. Ramipril melts
between 105
o
C and 112
o
C.
Ramipril's chemical name is
(2_S_,3a_S_,6a_S_)-1-[(_S_)-2-[[(_S_)-l-(ethoxycarbonyl)-3-phenylpropyl]
amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; its
structural formula is:
Its empiric formula is C
23
H
32
N
2
O
5
, and its molecular weight is 416.5. Ramipril has five chiral
centres. It has_ S_-configuration in all five asymmetric carbon atoms.
CAS NUMBER:
87333-19-5
PHARMACOLOGY
MECHANISM OF ACTION
Ramipril is a prodrug which, after absorption from the
gastrointestinal tract, is hydrolysed in the
liver
to
form
the
active
moiety,
ramiprilat.
Ramipril
and
ramiprilat
inhibit
angiotensin-
converting enzyme (ACE) which is identical to KININASE II. This
converting enzyme (ACE) is
a peptidyl dipeptidase that catalyses the conversion of angiotensin I
to the vasoconstrictor
substance, angiotensin II. Angiotensin II also stimulates aldosterone
secretion by the adrenal
cortex, thus inhibition of ACE results in decreased plasma angiotensin
II, which leads to
_Ramipril-Lupin Capsules_
_Product Information_
_Version_ 5 100714
Page 2 of 30
decreased vasopressor activity and to decreased aldosterone secretion.
The latter decrease may
result in a small increase in serum potassium.
KININASE II is one of the enzymes responsible for the degradation of
bradykinin, a potent
vasodepressor peptide.
The inhibition of KININASE II activity by ramipril prevents the
degradation of bradykinin thus leading to increased levels of this
potent vasodepressor substance.
While the mechanism through which ramipril lowers blood pressure is
believed to be primarily
suppression of the renin-angiotensin-aldosterone system, ramipril has
an antihypertensive effect
even in patients with low renin hypertension. Although ramipril was
anti