Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
quinapril hydrochloride
Sandoz Pty Ltd
quinapril hydrochloride
QUINAPRIL SANDOZ ® _Quinapril Hydrochloride Tablets_ (QUIN-A-PRIL HI-DRO-CLAW-RIDE) CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Quinapril Sandoz. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you taking Quinapril Sandoz against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may want to read it again. WHAT QUINAPRIL SANDOZ IS USED FOR The name of your medicine is Quinapril Sandoz. It contains the active ingredient quinapril hydrochloride. This medicine is used to lower high blood pressure (hypertension). It is also used to treat heart failure. HYPERTENSION Quinapril Sandoz is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure. HEART FAILURE Heart failure means that the heart muscle is weak and cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops. Heart failure may start off with no symptoms, but as the condition progresses, patients may feel short of breath or may get tired easily after light physical activity such as walking. Some patients may wake up short of breath at Read the complete document
_Product Information Page _ _Quinapril Sandoz 5mg and 20mg Tablets _ _02/2012_ _Sandoz Pty Ltd _ _ _ _Version 08 _ _1 _ PRODUCT INFORMATION QUINAPRIL SANDOZ ® 5MG AND 20MG TABLETS NAME OF THE MEDICINE _Generic Name: _Quinapril hydrochloride _Chemical Name:_ 2-(S)-[N-[[1-ethoxycarbonyl -3-phenylpropyl]- (S)-alanyl]-1,2,3,4- tetrahydro-3-(S)-isoquinolinecarboxylic acid, monohydrochloride _CAS Number: _82586-55-8 _Empirical formula:_ C 25 H 30 N 2 O 5 .HCl_ _ _ _ _MW: _475.0 DESCRIPTION Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents. The drug molecule contains three chiral centres but is present as the pure S-S-S-stereoisomer. _ _ In addition to quinapril hydrochloride, Quinapril Sandoz also contains lactose, microcrystalline cellulose, light magnesium oxide, crospovidone, magnesium stearate, titanium dioxide, hypromellose, macrogol 400, polysorbate 80, iron oxide yellow, iron oxide black. PHARMACOLOGY Pharmacodynamics Quinapril is de-esterified to the principal metabolite, quinaprilat, which is an inhibitor of angiotensin converting enzyme (ACE) activity in human subjects and animals. ACE is a peptidyl dipeptidase that catalyses the conversion of angiotensin I to the vasoconstrictor angiotensin II. The effect of quinapril in hypertension appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. Quinapril inhibits the elevation in blood pressure _Product Information Page _ _Quinapril Sandoz 5mg and 20mg Tablets _ _02/2012_ _Sandoz Pty Ltd _ _ _ _Version 08 _ _2 _ caused by intravenously administered angiotensin I, but has no effect on the pressor response to angiotensin II, noradrenaline or adrenaline. Angiotensin II also stimulates the secretion of aldosterone from the adrenal cortex, thereby facilitating renal sodium and fluid reabsorption. Reduced aldosterone secretion by quinapril may result in a small increase in serum potassium. In controlled hypertension trials, treatment with Read the complete document