Propofol Abbott

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Propofol

Available from:

Phebra Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

Propofol CMI 

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DBL
®
 PROPOFOL INJECTION 

Propofol _(pro-po-fole) _

CONSUMER MEDICINE INFORMATION 
_Date of dispensing _
_Consumer name _
_pharmacy name _
_Consumer address _
_pharmacy address _

WHAT IS IN THIS LEAFLET

This leaflet answers some 
common questions about DBL
® 
Propofol Injection. It does not 
contain all the available 
information. It does not take the 
place of talking to your doctor or 
anaesthetist. 

All medicines have risks and 
benefits.  Your doctor or 
anaesthetist has weighed the 
risks of you being given propofol 
against the benefits it is expected 
to have for you. 

IF YOU HAVE ANY CONCERNS ABOUT 
BEING GIVEN THIS MEDICINE, ASK 
YOUR DOCTOR OR ANAESTHETIST. 

KEEP THIS LEAFLET. 
You may need to read it again. 

WHAT DBL
® 
PROPOFOL 
INJECTION IS USED FOR

_GENERAL ANAESTHESIA _

DBL
® 
Propofol Injection is used 
as a short-acting general 
anaesthetic in adults, and 
children aged 3 years or older. 

A general anaesthetic is a 
medicine which produces general 
anaesthesia.  This is the condition 
of heavy sleep needed during 
surgery.  Propofol is short-acting, 
which means that patients go to 
sleep quickly, usually within 30 
seconds of receiving propofol, but 
then wake up quickly as it wears 
off.  

Propofol can be used for very 
short operations when only one 
injection is needed.   

Propofol can be used throughout 
longer operations if more is given 
as repeated doses.   

Propofol can also be used to start 
off anaesthesia (induction 
anaesthesia). This means the 
anaesthetist may change over to 
another anaesthetic once sleep is 
induced. 

_SEDATION _

Propofol can be given to adults 
and adolescents over 16 years of 
age in lower doses if they need to 
be sedated (calm) or sleepy, but 
do not need the heavy sleep of 
anaesthesia.  This type of 
sedation may be required during 
certain tests or procedures. 

Propofol can also be us

Summary of Product characteristics

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Propofol (propofol) 200mg/20mL, 1000mg/100mL,
500mg/50mL injection vial, 200mg/20mL injection 
ampoule 06.03.08 
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PRODUCT INFORMATION 

PROPOFOL

INJECTION 

NAME OF THE MEDICINE 

PROPOFOL 

The chemical name of propofol is 2,6-diisopropylphenol. 
Propofol has the following structural formula: 

The molecular weight of propofol is 178.27. 
CAS Number:   2078-54-8 

DESCRIPTION

Propofol Injection is a white, aqueous, isotonic emulsion of pH 6
to 8.5. 
Propofol Injection contains as the active
ingredient 10mg of propofol per 1mL.  It also contains 
the inactive ingredients glycerol, soya oil, sodium hydroxide,
egg lecithin and water for 
injections. 

PHARMACOLOGY

PHARMACOKINETICS 

Propofol is distributed rapidly with a half-life between 1.8
and 8.3 minutes. It is about 98% bound 
to plasma proteins. Propofol is metabolised by conjugation,
probably in the liver (half-life 
between 34 and 64 minutes). Inactive metabolites are excreted
by the kidney. Under the usual 
maintenance regimens, significant accumulation of propofol does
not occur. Propofol has a 
terminal half-life of elimination of between 184 and 502 minutes
which may be attributable to 
redistribution from
poorly perfused fatty tissue. From prolonged observations, it appears that the 
elimination half-life of propofol may be prolonged by an
extended period of sampling (ranging 
from 200 to 1,353 minutes). However, the blood
propofol concentration during this phase is 
considerably lower than that likely to induce sedation and
therefore prolongation of the terminal 
phase is not considered of clinical significance. 
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Propofol (propofol) 200mg/20mL, 1000mg/100mL,
500mg/50mL injection vial, 200mg/20mL injection 
ampoule 06.03.08 
Version 08 
INDICATIONS 

Short acting intravenous anaesthetic agent