Presmedic Paracetamol Suspension 250mg 5ml

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

Paracetamol

Available from:

Hovid Pharmacy Sdn. Bhd.

INN (International Name):

Paracetamol

Units in package:

120 ml

Manufactured by:

HOVID BERHAD

Patient Information leaflet

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
PRESMEDIC
PARACETAMOL
SUSPENSION
250MG/5ML
Paracetamol (250 mg in 5 ml)
1
WHAT IS IN THIS LEAFLET
1.
What Presmedic Paracetamol
Suspension is used for
2.
How Presmedic Paracetamol
Suspension works
3.
Before you use Presmedic
Paracetamol Suspension
4.
How to use Presmedic Paracetamol
Suspension
5.
While you are using Paracetamol
Syrup
6.
Side effects
7.
Storage and Disposal of
Paracetamol Syrup
8.
Product description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
11.
Serial Number
WHAT PRESMEDIC PARACETAMOL
SUSPENSION IS USED FOR
Presmedic Paracetamol Suspension is
used to relief fever, headache and
symptoms of colds and flu, toothache,
discomfort of teething and fever after
vaccination.
HOW PRESMEDIC PARACETAMOL
SUSPENSION WORKS
Presmedic Paracetamol Suspension
contains Paracetamol that helps to
block pain stimulation and it acts on
heat-regulating center in brain. This
results in increase in blood flow
through skin, sweating and heat loss.
BEFORE YOU USE PRESMEDIC
PARACETAMOL SUSPENSION
_ _
_- When you must not use it _
Do not take this medicine if:
•
You have ever had an allergic
reaction to paracetamol.
•
You have severe and active liver
impairment.
This preparation contains
PARACETAMOL. Do not take any
other paracetamol containing medicines
at the same time.
If you are not sure whether you should
start taking this medicine, talk to your
pharmacist or doctor.
_- Before you start to use it _
Tell your doctor if you are taking or
have recently taken any other
medicines, including medicines
obtained without a prescription, as they
may interact with Presmedic
Paracetamol Suspension.
Allergy alert: Paracetamol may cause
severe skin reactions. Symptoms may
include skin reddening, blisters or rash.
These could be signs of a serious
condition. If these reactions occur, stop
use and seek medical assistance right
away.
_ _
_- Taking other medicines_
The use of anti-psychotic medicines
such as barbiturate, tricyclic
antidepressants and alcohol m

Summary of Product characteristics

VIPARxx-0
DESCRIPTION
Pink, viscous suspension with raspberry flavour.
COMPOSITION
Each 5 ml contains:
Paracetamol 250 mg
PHARMACODYNAMICS
Paracetamol is a centrally acting analgesic and antipyretic with
minimal anti-inflammatory properties.
ANALGESIC:
The
mechanism
of
analgesic
action
has
not
been
fully
determined. Paracetamol may act predominantly by inhibiting
prostaglandin
synthesis
in
the
central
nervous
system
(specifically cyclooxygenase (COX)-2) and, to a lesser extent,
through a peripheral action by blocking pain-impulse generation.
The
peripheral
action
may
also
be
due
to
inhibition
of
prostaglandin synthesis or to inhibition of the synthesis or actions
of other substances that sensitize pain receptors to mechanical
or chemical stimulation.
ANTIPYRETIC:
Paracetamol act centrally on the hypothalamic heat-regulating
center to produce peripheral vasodilatation resulting in increase
blood flow through the skin, sweating and heat loss. Paracetamol
reduces
fever
by
inhibiting
the
formulation
and
release
of
prostaglandins
in
the
CNS
and
by
inhibiting
endogenous
pyrogens at the hypothalamic thermoregulator center.
PHARMACOKINETICS
Following oral administration paracetamol is rapidly absorbed.
Paracetamol absorption takes place mainly in the small intestine
and therefore the rate of absorption is depending on the rate of
gastric emptying. It has been shown that drugs which delay
gastric
emptying
also
delay
the
absorption
of
paracetamol
whereas metoclopramide (a drug which increases the rate of
gastric emptying) accelerates absorption of the analgesic through
the total amount absorbed doses not increase.
The presence of food in the stomach has also been reported to
reduce the rate of absorption of paracetamol. Alterations in
gastric pH have no appreciable effect on paracetamol absorption.
During
absorption,
the
amount
of
paracetamol
which
is
inactivated is negligible and it has been shown that paracetamol
does
not
affect
gastric
mucosal
permeability
and
does
not
produce mucosal bleeding.
Peak plasma concentration