POTASSIUM CHLORIDE solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

Potassium Chloride (UNII: 660YQ98I10) (Potassium Cation - UNII:295O53K152)

Available from:

Pharmaceutical Associates, Inc.

INN (International Name):

Potassium Chloride

Composition:

Potassium Chloride 3 g in 15 mL

Administration route:

ORAL

Prescription type:

PRESCRIPTION DRUG

Therapeutic indications:

1. For the treatment of patients with hypokalemia with or without metabolic alkalosis, in digitalis intoxication, and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia. 2. For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias. The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern, and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and, if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwar

Product summary:

Potassium Chloride Oral Solution USP 20% is clear and unflavored and is supplied in the following oral dosage form: NDC 0121-0466-16 in bottles of 16 fl oz (473 mL). Dispense in a tight, light-resistant container as defined in the USP. Protect from freezing. Keep tightly closed. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Protect from light.

Authorization status:

unapproved drug other

Summary of Product characteristics

POTASSIUM CHLORIDE- POTASSIUM CHLORIDE SOLUTION
PHARMACEUTICAL ASSOCIATES, INC.
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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POTASSIUM CHLORIDE
ORAL SOLUTION USP
(20% SOLUTION)
RX ONLY
DESCRIPTION
Potassium Chloride Oral Solution USP 20% is a sugar-free, clear
colorless solution. Each 15 mL
(tablespoonful) contains potassium chloride 3.0 g (supplying 40 mEq of
potassium and chloride) with
alcohol 5%.
The chemical name is potassium chloride, and the structural formula is
KCl. Potassium chloride USP
occurs as a white, granular powder or as colorless crystals. It is
odorless and has a saline taste. Its
solutions are neutral to litmus. It is freely soluble in water and
insoluble in alcohol.
Inactive Ingredients: _Glycerin, purified water, and sodium
saccharin._
CLINICAL PHARMACOLOGY
Potassium ion is the principal intracellular cation of most body
tissues. Potassium ions participate in a
number of essential physiological processes including the maintenance
of intracellular tonicity, the
transmission of nerve impulses, the contraction of cardiac, skeletal
and smooth muscle, and the
maintenance of normal renal function.
The intracellular concentration of potassium is approximately 150 to
160 mEq per liter. The normal
adult plasma concentration is 3.5 to 5 mEq per liter. An active ion
transport system maintains this gradient
across the plasma membrane.
Potassium is a normal dietary constituent and under steady state
conditions, the amount of potassium
absorbed from the gastrointestinal tract is equal to the amount
excreted in the urine. The usual dietary
intake of potassium is 50 to 100 mEq per day.
Potassium depletion will occur whenever the rate of potassium loss
through renal excretion and/or loss
from the gastrointestinal tract exceeds the rate of potassium intake.
Such depletion usually develops as a
consequence of therapy with diuretics, primary or secondary
hyperal