Potassium Chloride Sodium Chloride Glucose IV infusion

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Glucose - anhydrous; Sodium chloride; Potassium chloride

Available from:

Interclinical Laboratories Pty Ltd

Class:

Medicine Listed

Summary of Product characteristics

Potassium Chloride, Sodium Chloride, Glucose IV Infusion 
Product Information 

KCl NaCl Glucose PI Approved 001020 
 Page 1 of 9 
Baxter 

POTASSIUM CHLORIDE (%), SODIUM 
CHLORIDE (%) AND GLUCOSE (%) 
INTRAVENOUS INFUSION BP  

_Composition_: the active ingredients are Glucose (anhydrous),
Sodium Chloride and 
Potassium Chloride. The chemical name of glucose is
D- (+) glucopyranose. Molecular 
formulae of glucose, sodium chloride and potassium chloride are C
6
H
12
0
6
, NaCI and KCI, 
respectively. 

_Chemical Structure:_ 
C
6
H 
12
O
6
 and KCl 

DESCRIPTION 

Glucose is a monosaccharide, having physical characteristics as
a white crystal or 
granular powder and freely soluble in water. Sodium chloride arid
potassium chloride 
occur as a colourless or white crystal and are freely soluble
in water. 

The Potassium Chloride (%), Sodium Chloride (%) and
Glucose (%) Intravenous 
Infusion is a sterile, nonpyrogenic solution. The concentrations
of the active ingredients 
dissolved in a litre of water for injection are shown in Table 1
(see Presentation). They do 
not contain an antimicrobial agent or added buffer and have a pH
of 3.5 - 6.5. They are 
isotonic as reflected by their Osmolarities (calculated) listed in
Table 1. 

PHARMACOLOGY 

_Mechanism of Action:_ 
Glucose is readily metabolised into carbon dioxide and water with
a release of energy. 
Thus, administration of a glucose solution either by oral or
parenteral route will provide 
water for body hydration as well as energy. In addition, it
may reduce catabolic loss of 
nitrogen from the body and aid in prevention of depletion of
liver glycogen. That is, in 
the absence of glucose, amino acids undergo deamination followed
by oxidation in order 
to release energy. 

Potassium is the major cation
of intracellular fluid (160 mEq/liter of intracellular water) 
and functions princip