Country: United Kingdom
Language: English
Source: VMD (Veterinary Medicines Directorate)
Piperazine Citrate
Ayrton Saunders Limited
QP52AH01
Piperazine Citrate
Expired
Revised: November 2022 AN: 01984/2022 SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF VETERINARY MEDICINAL PRODUCT Piperazine Citrate Worm Tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Active Ingredient: Piperazine Citrate, 500mg/tablet 3. PHARMACEUTICAL FORM Tablet. 4. PHARMACOLOGICAL PROPERTIES Summary Presentation of the Active Ingredient Piperazine Citrate is an anthelmintic of low toxicity with a high efficiency against ascarids and some other nematodes. Pharmacodynamic Properties Piperazine acts to block neuromuscular transmission in the parasite by hyperpolarizing the nerve membrane, which leads to flaccid paralysis. It also blocks succinate production by the worm. The parasites, paralysed and depleted of energy, are expelled by peristalsis. It is active against the ascarids Toxocara canis, Toxocara cati/ roundworm, Toxascaris leonine and hookworms. Pharmacokinetic Properties Piperazine is rapidly absorbed from the GI tract, and piperazine base can be detected in the urine as early as 30 minutes after administration. The excretion rate is maximal at 1 – 8hr, and excretion is practically complete within 24hrs. ATC Vet Code QP52AH01 5. CLINICAL PARTICULARS 5.1 TARGET SPECIES Cat, Dog. 5.2 INDICATIONS FOR USE, SPECIFYING THE TARGET SPECIES Piperazine Citrate is indicated for the treatment and control of intestinal infections/ infestations of dogs and cats, and may be used from 2 weeks of age. 5.3 CONTRA-INDICATIONS Whilst piperazine salts have few side effects and are of low toxicity, care should be taken, especially with kittens and puppies, to ensure that the correct dosage is calculated by weighing the animal prior to Revised: November 2022 AN: 01984/2022 administration of the drug. Animals weighing less than 1.25kg should be treated with a suitable anthelmintic licensed for this purpose. Do not repeat treatment if vomiting occurs shortly after dosing. Do not administer more than 6 tablets in a single dose. If no vomiting occurs the remaining dose may be given after 3 hours. 5.4 UNDESIRABLE EFFECTS, Read the complete document