Perindo Combi

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Indapamide hemihydrate; Perindopril erbumine

Available from:

Servier Laboratories (Australia) Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

PERINDO
®
 COMBI
4/1.25

_perindopril (pronounced per-in-do-pril) and indapamide (pronounced
in-dap-a-mide)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about PERINDO COMBI
4/1.25. It does not contain all the
available information about this
medicine. Reading this leaflet does
not take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking PERINDO
COMBI 4/1.25 against the expected
benefits for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT PERINDO
COMBI 4/1.25 IS
The name of your medicine is
PERINDO COMBI 4/1.25. The
medicine contains the active
ingredients perindopril erbumine and
indapamide hemihydrate. Perindopril
belongs to a group of medicines
called angiotensin converting
enzyme (ACE) inhibitors.
Indapamide belongs to a group of
medicines called chlorosulphamoyl
diuretics.
WHAT PERINDO
COMBI 4/1.25 IS USED
FOR
YOU HAVE BEEN PRESCRIBED
PERINDO COMBI 4/1.25 FOR HIGH
BLOOD PRESSURE.
PERINDO COMBI 4/1.25 is
available only with a doctor's
prescription.
There is no evidence that PERINDO
COMBI 4/1.25 is addictive.
_WHY PERINDO COMBI 4/1.25_
_IS USED FOR HIGH BLOOD_
_PRESSURE_
Everyone has blood pressure. This
pressure helps to circulate blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or stressed you are. You have
high blood pressure (also known as
hypertension) when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
If high blood pressure is not treated it
can lead to serious health problems.
You may feel fine and have no
symptoms, but eventually it can
cause stroke, heart disease and
kidney failure.
PERINDO COMBI 4/1.25 helps to
lower your blood pressure.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY PERINDO
COMBI 4/1.25 HAS BEEN PRESCRIBED
FO

Summary of Product characteristics

PERINDO COMBI 4/1.25 
–PRODUCT INFORMATION 

   1 (26) 

Version 6a 

PRODUCT INFORMATION 

NAME OF THE MEDICINE 

_PERINDO COMBI 4/1.25 _
Perindopril erbumine 4 mg / Indapamide hemihydrate 1.25 mg 

Perindopril erbumine 

Perindopril erbumine is a dipeptide monoacid monoester with
a perhydroindole group and no 
sulphydryl radical; chemical name, tert-butylammonium (2_S_, 3a_S_, 7a_S_)-1-(_N_-[(_S_)-1-ethoxycarbonyl 
butyl]-L-alanyl) perhydroindole-2-carboxylate. 

_CAS Registry Number _: 107133-36-8 
_ _
_Molecular formula _: C
19
H
32
N
2
O
5 
, C
4
H
11
N 

_Chemical structure _: 

Indapamide 

Indapamide is a non thiazide indole derivative
of chlorosulphonamide; chemical name 4-chloro-_N_-
(2 methyl-1-indolinyl)-3-sulphamoyl benzamide hemihydrate. 

_CAS Registry Number _: 26807-65-8 

_Molecular formula _: C
16
H
16
ClN
3
O
3
S, ½ H2O 

_Chemical structure _: 

, 
½ 
H
2
O

PERINDO COMBI 4/1.25 
–PRODUCT INFORMATION 

   2 (26) 

Version 6a 

DESCRIPTION 

Active Ingredients 

Perindopril erbumine is a white powder, readily soluble
in purified water, ethanol and chloroform.  
Perindopril has five asymmetric centres and
is synthesised stereoselectively so that it is a single 
enantiomer (all _S_ stereochemistry). 
Indapamide is a white crystalline lipophilic powder, soluble
in methanol, ethanol, acetic acid and 
ethyl acetate, very slightly soluble in ether, chloroform and
benzene and practically insoluble in 
water. 

Excipients 

Microcrystalline cellulose, lactose, magnesium stearate, colloidal anhydrous silica._ _

PHARMACOLOGY 

MECHANISM OF ACTION  

PERINDO COMBI 4/1.25 is a combination of perindopril erbumine, an angiotensin
converting 
enzyme (ACE) inhibitor, and indapamide, a
chlorosulphamoyl diuretic, in which the dose