Pancuronium Bromide Injection BP

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Pancuronium bromide

Patient Information leaflet

PANCURONIUM BROMIDE INJECTION BP
1
PANCURONIUM
BROMIDE INJECTION
B.P.
_Pancuronium Bromide_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions people ask about
Pancuronium Bromide Injection.  It
does not contain all the information
that is known about Pancuronium
Bromide Injection.
It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and
benefits.  Your doctor will have
weighed the risks of you being given
Pancuronium Bromide Injection
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING GIVEN THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT PANCURONIUM
BROMIDE INJECTION IS FOR
Pancuronium Bromide Injection is
used to stop your muscles moving
during surgery or in intensive care.
It belongs to a group of medicines
called neuromuscular blockers,
which work by stopping messages
being sent from the nerves to the
muscles.
Your doctor will have explained why
you are being treated with
Pancuronium Bromide Injection.
FOLLOW ALL DIRECTIONS GIVEN TO YOU
BY YOUR DOCTOR CAREFULLY. THEY
MAY DIFFER FROM THE INFORMATION
CONTAINED IN THIS LEAFLET.
Your doctor may prescribe this
medicine for another use. Ask your
doctor if you want more information.
Pancuronium Bromide Injection is
not addictive.
BEFORE YOU ARE GIVEN
PANCURONIUM BROMIDE
INJECTION
You may already have been given
Pancuronium Bromide Injection.
Your doctor will have considered the
situation carefully and decided to use
it.  However, if any of the following
applies to you, tell your doctor
immediately.
_WHEN YOU MUST NOT USE IT_
YOU MUST NOT BE GIVEN
PANCURONIUM BROMIDE INJECTION IF
YOU:
*
ARE SENSITIVE TO PANCURONIUM
BROMIDE OR TO THE BROMIDE ION
*
HAVE AN ALLERGY TO ANY
INGREDIENT LISTED AT THE END OF
THIS LEAFLET OR ANY OTHER RELATED
MEDICINES.
If you have an allergic react

Summary of Product characteristics

Pancuronium Bromide Injection B.P. Product Information   
1 (10)
PANCURONIUM INJECTION BP
Pancuronium Bromide 2 mg/mL
PRODUCT INFORMATION
NAME OF THE DRUG
The Australian Approved Name is pancuronium bromide (molecular formula
C
35
H
60
Br
2
N
2
O
4
).  The chemical name for pancuronium bromide is 2
β,16β-
dipiperidino-5
α-androstane-3α,17β-diol diacetate dimethobromide.  The CAS number
for pancuronium bromide is 15500-66-0.
Chemical structure:
DESCRIPTION
A sterile solution of pancuronium bromide suitable for IV injection.
 Each 2 mL
ampoule contains pancuronium bromide 4 mg, sodium acetate 4 mg,
sodium chloride
6 mg in Water for Injections BP; pH 3.5 - 4.2.
PHARMACOLOGY
Pancuronium bromide is a nondepolarising neuromuscular blocking agent
of medium
duration, blocking transmission of motor nerve impulses to striated
muscle receptors,
producing skeletal muscle paralysis. It competes with acetylcholine
for cholinergic
receptor sites.  It has little agonist activity, having no
depolarising effect at the motor
endplate.  Skeletal muscle relaxation starts with muscles associated
with fine
movements, e.g. eyes, face and neck, then followed by muscles of the
limbs, chest,
abdomen and finally the diaphragm.  Larger doses increase the risk
of respiratory
depression due to relaxation of the intercostal muscle and diaphragm.
 Muscle tone
returns in the reverse order.  Pancuronium bromide also increases
heart rate by a
direct blocking effect on acetylcholine receptors in the heart, but
this effect is small
with therapeutic doses. It produces little or no significant ganglion
blockade, so
hypotension and bronchospasm are not associated with its use.  The
muscle weight-
to-body weight ratio, the volume of extracellular fluid and renal
function also
contribute to response.
Pancuronium Bromide Injection B.P. Product Information   
2 (10)
Despite its steroid structure, pancuronium bromide exhibits no
hormonal activity.
Cholinesterase inhibitors such as pyridostigmine and neostigmine
reverse the actio