Olmetec Plus

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Olmesartan medoxomil; Hydrochlorothiazide

Available from:

Merck Sharp & Dohme Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

OLMETEC PLUS
®

_Olmesartan medoxomil and hydrochlorothiazide_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about OLMETEC PLUS.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking OLMETEC
PLUS against the benefits he/she
expects it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
OLMETEC PLUS TABLETS.
You may need to read it again.
WHAT OLMETEC PLUS
IS USED FOR
OLMETEC PLUS is used to treat
high blood pressure which is
sometimes called hypertension.
Everyone has blood pressure. This
pressure helps push blood all around
your body. Your blood pressure
changes at different times of the day,
depending on how busy or worried
you are. You have hypertension (high
blood pressure) when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems,
including stroke, heart disease and
kidney failure.
_HOW OLMETEC PLUS WORKS_
OLMETEC PLUS belongs to a group
of medicines known as angiotensin-II
receptor antagonists. Angiotensin-II
is a substance produced in the body
which causes blood vessels to
tighten. OLMETEC PLUS blocks the
action of angiotensin-II and therefore
relaxes your blood vessels. This
helps lower your blood pressure.
OLMETEC PLUS also contains a
diuretic which reduces the amount of
fluid in the body. This also helps to
lower blood pressure.
Your doctor may have prescribed
OLMETEC PLUS for another
reason. Ask your doctor if you have
any questions about why OLMETEC
PLUS has been prescribed for you.
OLMETEC PLUS is not addictive.
This medicine is available only wit

Summary of Product characteristics

Olmetec Plus PI v7 A111221CCDS ref v5
101130 LRN S-000000–OLM/HCTZ-TB-PIPB.1 
Page 1

APPROVED PRODUCT INFORMATION 
OLMETEC PLUS® 
(olmesartan medoxomil/hydrochlorothiazide) 
OLMETEC PLUS 20/12.5 mg 
OLMETEC PLUS 20/25 mg 
OLMETEC PLUS 40/12.5 mg 
OLMETEC PLUS 40/25 mg 
NAME OF THE MEDICINE 
OLMETEC PLUS consists of olmesartan medoxomil and
hydrochlorothiazide (HCTZ). 
Olmesartan medoxomil is a prodrug, hydrolyzed to
olmesartan during absorption from the 
gastrointestinal tract.  Olmesartan is a selective AT
1
 subtype angiotensin II receptor 
antagonist.  HCTZ is a thiazide diuretic. 
Olmesartan medoxomil (CAS no. 144689-63-4) is described chemically as 2,3-dihydroxy-2-
butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[_p_-(_o_-1H-tetrazol-5-ylphenyl) benzyl] 
imidazole-5-carboxylate, cyclic 2,3-carbonate. 
Its empirical formula is C
29
H
30
N
6
O
6
 and its structural formula is: 
HCTZ (CAS no. 58-93-5) is described chemically as 6-chloro-3,4-dihydro-2_H_-1,2,4-
benzothiadiazine-7-sulfonamide 1,1-dioxide. 
The empirical formula is C
7
H
8
ClN
3
O
4
S
2 
and the structural formula is: 

DESCRIPTION 
Olmesartan medoxomil is a white to light yellowish-white
powder or crystalline powder with a 
molecular weight of 558.59.  It is practically insoluble in
water and sparingly soluble in 
methanol. 
Olmetec Plus PI v7 A111221CCDS ref v5
101130 LRN S-000000–OLM/HCTZ-TB-PIPB.1 
Page 2

HCTZ is a white, or almost white, crystalline powder, with a
molecular weight of 297.7.  
HCTZ is very slightly soluble in water, soluble
in acetone, sparingly soluble in alcohol.  It 
dissolves in dilute solutions of alkali hydroxides. 
OLMETEC PLUS is available for oral use
as film-coated tablets containing 20/12.5 mg, 
20/25 mg, 40/12.5 mg, or 40/25 mg olmesartan
medoxomil/HCTZ.  OLMETEC PLUS tablets 
also contain the following inactive ingredie