Country: United States
Language: English
Source: NLM (National Library of Medicine)
NIMODIPINE (UNII: 57WA9QZ5WH) (NIMODIPINE - UNII:57WA9QZ5WH)
Cardinal Health
NIMODIPINE
NIMODIPINE 30 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
NIMODIPINE- NIMODIPINE CAPSULE CARDINAL HEALTH ---------- DO NOT ADMINISTER NIMODIPINE INTRAVENOUSLY OR BY OTHER PARENTERAL ROUTES. DEATHS AND SERIOUS, LIFE THREATENING ADVERSE EVENTS HAVE OCCURRED WHEN THE CONTENTS OF NIMODIPINE CAPSULES HAVE BEEN INJECTED PARENTERALLY (SEE WARNINGS AND DOSAGE AND ADMINISTRATION). DESCRIPTION Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers. Nimodipine is isopropyl 2 - methoxyethyl 1, 4 - dihydro - 2, 6 - dimethyl - 4 - (m-nitrophenyl) - 3, 5 – pyridinedicarboxylate. It has a molecular weight of 418.5 and a molecular formula of C H N O The structural formula is: Nimodipine is a yellow crystalline substance, practically insoluble in water. Nimodipine capsules are formulated as soft gelatin capsules for oral administration. Each liquid filled capsule contains 30 mg of Nimodipine USP in a vehicle of glycerin, peppermint oil, purified water and polyethylene glycol. The soft gelatin shell contains gelatin, D&C Yellow #10, glycerin, titanium dioxide and purified water. The ingredients in the edible imprinting ink contain ammonium hydroxide, black iron oxide, n-butyl alcohol, isopropyl alcohol, shellac glaze in ethanol and propylene glycol. In addition, the capsule may contain trace amounts of fractionated coconut oil. CLINICAL PHARMACOLOGY MECHANISM OF ACTION: Nimodipine is a calcium channel blocker. The contractile processes of smooth muscle cells are dependent upon calcium ions, which enter these cells during depolarization as slow ionic 21 26 2 7. transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments, nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic, allowing it to cross the blood-brain barrier; concentrations of nimodipine as high as 12.5 ng/mL have been detected in the cerebrospinal fluid of nimodipine-treated subarachnoid hemorrhage (SAH) patients Read the complete document