Nicarbazine Premix 25% ww Powder

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

NICARBAZINE

Available from:

Weissen Company (m) Sdn. Bhd.

INN (International Name):

NICARBAZINE

Units in package:

25.00 mcg/mL

Manufactured by:

Shandong Luxi Animal Medicine Share Co., Ltd

Summary of Product characteristics

PACKAGE INSERT
Brand or product name
Nicarbazine Premix 25% w/w Powder
Name and Strength of
Active Substance
Nicarbazine 25%
Product Description
Yellow Powder
Pharmacodynamics
The agents are absorbed separately from the digestive tract, and
both
are
needed
for
anticoccidial
activity.
Dry
crystals
are
strongly electrostatic and present some dry mixing problems.
The precise mode of action of nicarbazin is not known.
Pharmacokinetics
Broiler
chickens
were
fed
a
diet
containing
15
mg/kg
of
nicarbazin, [
14
C]-labeled in both phenylurea and pyrimidinone,
for 7 days and groups of birds were sacrificed between day 2 and
day 7. Concentrations of the [
14
C]-labeled phenylurea portion of
the complex were much higher in liver and kidney than in
plasma and muscle. [
14
C]-labeled pyrimidinone concentrations
were highest in kidney, they were not significantly lower in
muscle, plasma and liver. Liver and kidney concentrations of the
pyrimidinone portion of the nicarbazin complex are about 10
times less that the concentrations of the phenylurea portion of
the complex. The rapid elimination of the pyrimidinone portion
of nicarbazin and the non-detection of metabolites has led to an
almost exclusive focus on the phenylurea portion of the complex
in subsequent metabolism and residue depletion studies.
Environmental Properties
(for product used directly in
the environment e.g.
medicine for fish)
N/A
Indication
Aid
in
preventing
outbreaks
of
cecal
(Elmeria
tenella)
and
intestinal (E. acervulina, E. maxima, E. necatrix and E. brunetti)
coccidiosis.
Recommended Dosage
113.5 (0.0125 percent) grams Nicarbazin per ton of feed
Mode of Administration
Oral Administration
Contra-indications
Do not use in know cases of hypersensitivity to active
ingredient.
Warnings and Precautions
It is forbidden for layers or breeders.
Interactions with Other
Medicaments
In the absence of compatibility studies, this veterinary medicinal
product must not be mixed with other products.
Statement on usage during
pregnancy and lactation
In the absence of toxico