Nervit B Forte Tablet

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

Thiamine Mononitrate (Vitamin B1); PYRIDOXINE HCL/VITAMIN B6; Cyanocobalamin

Available from:

PAHANG PHARMACY SDN. BHD.

INN (International Name):

Thiamine Mononitrate (Vitamin B1); PYRIDOXINE HCL/VITAMIN B6; Cyanocobalamin

Units in package:

10 Tablet Tablets; 30 Tablet Tablets; 60 Tablet Tablets; 500 Tablet Tablets; 100 Tablet Tablets

Manufactured by:

PAHANG PHARMACY SDN. BHD.

Summary of Product characteristics

Package Insert
NERVIT B FORTE TABLET
COMPOSITION:
Each tablet contains:
Thiamine Mononitrate (Vitamin B
1)
250 mg
Pyridoxine HCl
(Vitamin B
6)
250 mg
Cyanocobalamin
(Vitamin B
12)
1 mg
DESCRIPTION:
A pink color round shaped film coated tablet with 13mm diameter.
PHARMACOLOGY:
Thiamine is a water-soluble vitamin. It is an essential nutrient
required for carbohydrate metabolism and
is also involved in nerve transmission.
Pyridoxine,
a water-soluble vitamin,
is involved principally in
amino acid metabolism, but is also involved in carbohydrate and fat
metabolism. It is also required for
the formation of haemoglobin.
Cyanocobalamin influences hematopoiesis.
It
is involved in formation
and metabolism of purines and pyrimidine, and in the synthesis of
nucleoproteins.
PHARMACOKINETICS:
Thiamine, Pyridoxine and Cyanocobalamin are absorbed from
gastrointestinal tract.
Thiamine is widely distributed to most body tissue; it is not stored
in the body. Thiamine is excreted in
urine as unchanged form or as its metabolites, pyrimidine.
Pyridoxine is converted to its active form pyridoxal phosphate and
transformed to pyridoxic acid which
is excreted in the urine.
Cyanocobalamin is bound to plasma proteins and stored in the liver.
It
is excreted in the bile and
undergoes some enterohepatic recycling. It is also excreted in urine.
INDICATION:
For neurological and other disorders associated with disturbance of
the nerve cell metabolism in which
high-dose B complex vitamins play a role. These include: polyneuritis
(of toxic and non-toxic etiology);
neuralgias
eg,
lumbalgia,
trigeminal
neuralgia,
shoulder-arm syndrome,
herpes
zoster,
cervical
syndrome, ischialgia, etc; diabetic neuropathy; metabolic and
neuropathic changes due to pregnancy and
oral contraceptives; convalescence.
CONTRAINDICATION:
Known hypersensitivity to vitamins B
1
, B
6
or B
12
.
Should not be used in patients on Levodopa therapy.
DOSAGE AND DIRECTIONS:
_Therapeutic Dose_: Take 2-3 tablets daily after meals for 7-10 days.
_Maintenance Dose_: 1 tablet daily after