M.T.E.-4 SOLUTION

Country: Canada

Language: English

Source: Health Canada

Active ingredient:

ZINC (ZINC SULFATE); COPPER (CUPRIC SULFATE); MANGANESE (MANGANESE SULFATE); CHROMIUM (CHROMIC CHLORIDE)

Available from:

PHARMACEUTICAL PARTNERS OF CANADA INC

ATC code:

B05XA30

INN (International Name):

COMBINATIONS OF ELECTROLYTES

Dosage:

1MG; 0.4MG; 0.1MG; 4MCG

Pharmaceutical form:

SOLUTION

Composition:

ZINC (ZINC SULFATE) 1MG; COPPER (CUPRIC SULFATE) 0.4MG; MANGANESE (MANGANESE SULFATE) 0.1MG; CHROMIUM (CHROMIC CHLORIDE) 4MCG

Administration route:

INTRAVENOUS

Units in package:

3/10ML

Prescription type:

Ethical

Therapeutic area:

REPLACEMENT PREPARATIONS

Product summary:

Active ingredient group (AIG) number: 0414689003; AHFS:

Authorization status:

APPROVED

Authorization date:

2008-02-14

Summary of Product characteristics

PRODUCT MONOGRAPH
M.T.E.-4 AND M.T.E.-4 CONCENTRATED
_Multi-Trace Element _
Pharmaceutical Partners of Canada Inc.
Date of Preparation:
45 Vogell Road, Suite 200
January 15, 2008
Richmond Hill, ON
L4B 3P6
Control No.: 119203
1
NAME OF DRUG
M.T.E.-4 AND
M.T.E.-4 CONCENTRATED
THERAPEUTIC CLASSIFICATION
Multi-Trace Element
ACTIONS AND CLINICAL PHARMACOLOGY
ZINC
Zinc is an essential nutritional element that plays a key role as a
component of numerous metalloenzymes
such as carbonic anhydrase, alkaline phosphatase, lactic dehydrogenase
and carboxypeptidase. At least
one zinc metalloenzyme has been identified in each of the six major
categories of enzymes; i.e.,
oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase.
Zinc is also necessary for the
synthesis of RNA and DNA, making it important in the normal growth and
development process. Zinc
helps maintain normal skin hydration and the senses of taste and smell
and facilitates wound healing.
Zinc resides in muscle, bone, skin, kidney, liver, pancreas, retina,
prostate and particularly in red and
white blood cells. Calculations from data indicate that 75 to 88% of
the total zinc of normal blood is
contained in red cells (primarily in the zinc metalloenzyme carbonic
anhydrase), 12 to 22% in the plasma
and 3% in the leukocytes. Normal plasma levels of zinc vary from
approximately 88 to 112 μg/100 mL.
Practically all zinc in serum is protein bound including plasma
albumin, α
2
-macroglobulin and some
plasma amino acids including histidine, cysteine, threonine, glycine
and asparagine. Infection influences
the uptake of zinc by the liver and reduces plasma concentration. This
process is stimulated by leukocyte
endogenous mediator (LEM).
Absorption of zinc occurs mainly in the small intestine, predominantly
in the duodenum. The primary
excretory pathway for zinc is the feces and pancreatic secretion. The
largest component comes from direct
transfer of zinc through the intestinal wall. Several researchers
showed that diarrhea, stomal and fistula
losses were maj