Maxipime

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Cefepime

Available from:

Bristol-Myers Squibb Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

MAXIPIME
®

_Cefepime (SEFF-eh-peem)_

CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
The medicine which your doctor has
prescribed for you is called
Maxipime. The information in this
leaflet answers some questions you
may have about Maxipime.
This leaflet does not contain all the
information about Maxipime. Your
doctor or pharmacist has been
provided with full information, and
can answer any questions you may
have. Follow your doctor's advice,
even if it differs from what is in this
leaflet.
You should read this leaflet carefully
before Maxipime is given to you.
Keep this leaflet in a safe place, you
may need to read it again.
WHAT MAXIPIME IS
USED FOR
Maxipime contains cefepime which
belongs to a group of antibiotics
called cephalosporins. These
antibiotics work by killing the
bacteria that are causing the
infection.
Maxipime is an injectable antibiotic
used for serious infections in adults
caused by bacteria in the lungs
(pneumonia and bronchitis), in the
kidney and bladder (urinary tract
infections), in the skin, inside the
abdomen (peritonitis and biliary tract
infections), in the womb or vagina, or
in the blood (septicaemia). It may be
given before surgery or if you have a
lack of white blood cells with fever.
Maxipime is also used for serious
infections in children over 2 months
of age caused by bacteria in the lungs
(pneumonia), in the kidney and
bladder (urinary tract infections), or
in the skin; or in the blood; or if the
child has a lack of white blood cells
with fever.
There may be other reasons why your
doctor has prescribed Maxipime. Ask
your doctor why Maxipime has been
prescribed for you.
BEFORE YOU ARE GIVEN
MAXIPIME
_WHEN YOU MUST NOT BE GIVEN_
_MAXIPIME_
You must not take Maxipime if you
have a history of severe allergic
reactions to Maxipime,
cephalosporins or to any of the
ingredients listed at the end of this
leaflet. Symptoms of a severe allergic
reaction may include; chills, fever,
fast heart beat, wheezing or
coughing, difficulty breathing,
dizziness, flushing, sw

Summary of Product characteristics

1 

Maxipime V2.0 1November 2012 

MAXIPIME

Cefepime (as cefepime hydrochloride) 

powder for injection 

(500mg, 1g and 2g vials) 

APPROVED NAME: 

Cefepime hydrochloride. 

DESCRIPTION: 

Cefepime  hydrochloride  is  a  semi-synthetic  broad  spectrum  cephalosporin  antibiotic  for 
parenteral  administration.    The  chemical  name  is  Pyrrolidinium,  1-[[7-[[(2-amino-4-
thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-
yl]  methyl]-1-methyl-,chloride,  monohydrochloride,  monohydrate,  [6R-[6

,7

(Z)]],  which 
corresponds to the following structural formula: 

Cefepime  hydrochloride  is  a  white  to  pale  yellow  powder  with  a  molecular  formula  of 
C
19
H
25
N
6
O
5
S
2
.Cl.HCl.H
2
O and a molecular weight of 571.5.  It is highly soluble in water.  

PHARMACOLOGY: 

PHARMACOKINETICS (IN ADULTS): 

Average plasma concentrations of cefepime observed in normal adult males at various times 
following  single  30-minute  infusions  of  500mg,  1g  and  2g  are  summarised  in  Table  1.  
Following intramuscular administration, cefepime is completely absorbed.  The average plasma 
concentrations of cefepime at various times following a single IM injection are summarised in 
Table 1. 

2 

Maxipime V2.0 1November 2012 

TABLE 1 

MEAN PLASMA CONCENTRATIONS OF CEFEPIME (MCG/ML) 

_Cefepime dose _
_ _
_0.5 hr _
_ _
_1 hr _
_ _
_2 hr _
_ _
_4 hr _
_ _
_8 hr _
_ _
_12 hr _
_ _
500mg IV 

  33.6 

18.9 

11.3 

4.6 

1.0 

0.6 

1g IV 

66.9 

41.8 

25.3 

11.0 

2.8 

0.8 

2g IV 

127.6 

81.7 

45.4 

20.1 

4.6 

1.2 

500mg IM 

8.2 

12.5 

12.0 

6.9 

1.9 

0.7 

1g IM�