LORAZEPAM- lorazepam tablet

United States - English - NLM (National Library of Medicine)

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Active ingredient:
LORAZEPAM (UNII: O26FZP769L) (LORAZEPAM - UNII:O26FZP769L)
Available from:
NuCare Pharmaceuticals,Inc.
Administration route:
ORAL
Prescription type:
PRESCRIPTION DRUG
Therapeutic indications:
Lorazepam tablets USP are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. The effectiveness of lorazepam tablets USP in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient. Lorazepam tablets are contraindicated in patients with - hypersensitivity to benzodiazepines or to any components of the formulation. - acute narrow-angle glaucoma.
Product summary:
1 mg, white to off-white, round, flat-faced beveled edge tablets debossed with U33 on one side and bisect on other side. NDC 68071-5022-5 BOTTLES OF 15 DISPENSE IN A TIGHT, LIGHT-RESISTANT CONTAINER AS DESCRIBED IN THE USP. STORE AT 20°C to 25°C (68°to 77°F). [SEE USP CONTROLLED ROOM TEMPERATURE.] Manufactured by: Aurolife Pharma LLC Dayton, NJ 08810 Manufactured for: Aurobindo Pharma USA, Inc. Dayton, NJ 08810 Revised:11/2017 MEDICATION GUIDE LORAZEPAM Tablets, USP CIV What is the most important information I should know about LORAZEPAM? o Do not drive, operate heavy machinery, or do other dangerous activities until you know how LORAZEPAM affects you. o Do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking LORAZEPAM without first talking to your healthcare provider. When taken with alcohol or drugs that cause sleepiness or dizziness, LORAZEPAM may make your sleepiness or dizziness much worse. What is LORAZEPAM? LORAZEPAM is a prescription medicine used: o to treat anxiety disorders o for the short-term relief of the symptoms of anxiety or anxiety that can happen with symptoms of depression LORAZEPAM is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep LORAZEPAM in a safe place to prevent misuse and abuse. Selling or giving away LORAZEPAM may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines or street drugs. Do not take LORAZEPAM if you: Before you take LORAZEPAM, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking LORAZEPAM with certain other medicines can cause side effects or affect how well LORAZEPAM or the other medicines work. Do not start or stop other medicines without talking to your healthcare provider. How should I take LORAZEPAM? What should I avoid while taking LORAZEPAM? What are the possible side effects of LORAZEPAM? LORAZEPAM may cause serious side effects, including: The most common side effects of LORAZEPAM include: sedation dizziness weakness unsteadiness These are not all the possible side effects of LORAZEPAM. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. How should I store LORAZEPAM? General information about the safe and effective use of LORAZEPAM. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use LORAZEPAM for a condition for which it was not prescribed. Do not give LORAZEPAM to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about LORAZEPAM that is written for health professionals. What are the ingredients in LORAZEPAM? Active ingredient: lorazepam Inactive ingredients: anhydrous lactose, magnesium stearate, and microcrystalline cellulose and polacrilin potassium. This Medication Guide has been approved by the U.S. Food and Drug Administration Manufactured by: Aurolife Pharma LLC Dayton, NJ 08810 Manufactured for: Aurobindo Pharma USA, Inc. Dayton, NJ 08810 Revised:11/2017
Authorization status:
Abbreviated New Drug Application
Authorization number:
68071-5022-5

LORAZEPAM- lorazepam tablet

NuCare Pharmaceuticals,Inc.

----------

Lorazepam Tablets USP CIV

WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS

Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory

depression, coma, and death (see WARNINGS; PRECAUTIONS, Clinically Significant Drug

Interactions).

Reserve concomitant prescribing of these drugs for use in patients for whom alternative

treatment options are inadequate.

Limit dosages and durations to the minimum required.

Follow patients for signs and symptoms of respiratory depression and sedation.

DESCRIPTION

Lorazepam, an antianxiety agent, has the chemical formula, 7-chloro-5-( o-chlorophenyl)-1,3-dihydro-3-

hydroxy-2 H-1,4-benzodiazepin-2-one:

It is a nearly white powder almost insoluble in water. Each lorazepam tablet USP, to be taken orally,

contains 0.5 mg, 1 mg, or 2 mg of lorazepam USP. The inactive ingredients present are anhydrous

lactose, magnesium stearate, microcrystalline cellulose, and polacriline potassium.

CLINICAL PHARMACOLOGY

Studies in healthy volunteers show that in single high doses lorazepam has a tranquilizing action on the

central nervous system with no appreciable effect on the respiratory or cardiovascular systems.

Lorazepam is readily absorbed with an absolute bioavailability of 90 percent. Peak concentrations in

plasma occur approximately 2 hours following administration. The peak plasma level of lorazepam from

a 2 mg dose is approximately 20 ng/mL.

The mean half-life of unconjugated lorazepam in human plasma is about 12 hours and for its major

metabolite, lorazepam glucuronide, about 18 hours. At clinically relevant concentrations, lorazepam is

approximately 85% bound to plasma proteins. Lorazepam is rapidly conjugated at its 3-hydroxy group

into lorazepam glucuronide which is then excreted in the urine. Lorazepam glucuronide has no

demonstrable CNS activity in animals.

The plasma levels of lorazepam are proportional to the dose given. There is no evidence of

accumulation of lorazepam on administration up to six months.

Studies comparing young and elderly subjects have shown that advancing age does not have a significant

effect on the pharmacokinetics of lorazepam. However, in one study involving single intravenous doses

of 1.5 to 3 mg of lorazepam injection, mean total body clearance of lorazepam decreased by 20% in 15

elderly subjects of 60 to 84 years of age compared to that in 15 younger subjects of 19 to 38 years of

age.

INDICATIONS AND USAGE

Lorazepam tablets USP are indicated for the management of anxiety disorders or for the short-term

relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension

associated with the stress of everyday life usually does not require treatment with an anxiolytic.

The effectiveness of lorazepam tablets USP in long-term use, that is, more than 4 months, has not been

assessed by systematic clinical studies. The physician should periodically reassess the usefulness of

the drug for the individual patient.

CONTRAINDICATIONS

Lorazepam tablets are contraindicated in patients with

- hypersensitivity to benzodiazepines or to any components of the formulation.

- acute narrow-angle glaucoma.

WARNINGS

Concomitant use of benzodiazepines, including Lorazepam, and opioids may result in profound sedation,

respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of

these drugs for use in patients for whom alternative treatment options are inadequate.

Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines

increases the risk of drug-related mortality compared to use of opioids alone. If a decision is made to

prescribe Lorazepam concomitantly with opioids, prescribe the lowest effective dosages and minimum

durations of concomitant use, and follow patients closely for signs and symptoms of respiratory

depression and sedation. In patients already receiving an opioid analgesic, prescribe a lower initial dose

of Lorazepam than indicated in the absence of an opioid and titrate based on clinical response. If an

opioid is initiated in a patient already taking Lorazepam, prescribe a lower initial dose of the opioid and

titrate based upon clinical response.

Advise both patients and caregivers about the risks of respiratory depression and sedation when

Lorazepam is used with opioids. Advice patients not to drive or operate heavy machinery until the

effects of concomitant use with the opioid have been determined (see PRECAUTIONS, Clinically

Significant Drug Interactions).

Pre-existing depression may emerge or worsen during use of benzodiazepines including lorazepam.

Lorazepam is not recommended for use in patients with a primary depressive disorder or psychosis.

Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS

depressants, may lead to potentially fatal respiratory depression. (See PRECAUTIONS, Clinically

Significant Drug Interactions.)

Use of benzodiazepines, including lorazepam, may lead to physical and psychological dependence.

As with all patients on CNS-depressant drugs, patients receiving lorazepam should be warned not to

Operate dangerous machinery or motor vehicles and that their tolerance for alcohol and other CNS

depressants will be diminished.

Physical and Psychological Dependence

The use of benzodiazepines, including lorazepam, may lead to physical and psychological dependence.

The risk of dependence increases with higher doses and longer term use and is further increased in

patients with a history of alcoholism or drug abuse or in patients with significant personality disorders.

The dependence potential is reduced when lorazepam is used at the appropriate dose for short-term

treatment. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful

surveillance when receiving lorazepam or other psychotropic agents.

In general, benzodiazepines should be prescribed for short periods only (e.g., 2 to 4 weeks). Extension

of the treatment period should not take place without reevaluation of the need for continued therapy.

Continuous long-term use of product is not recommended. Withdrawal symptoms (e.g., rebound

insomnia) can appear following cessation of recommended doses after as little as one week of therapy.

Abrupt discontinuation of product should be avoided and a gradual dosage-tapering schedule followed

after extended therapy.

Abrupt termination of treatment may be accompanied by withdrawal symptoms. Symptoms reported

following discontinuation of benzodiazepines include headache, anxiety, tension, depression, insomnia,

restlessness, confusion, irritability, sweating, rebound phenomena, dysphoria, dizziness, derealization,

depersonalization, hyperacusis, numbness/tingling of extremities, hypersensitivity to light, noise, and

physical contact/perceptual changes, involuntary movements, nausea, vomiting, diarrhea, loss of

appetite, hallucinations/delirium, convulsions/seizures, tremor, abdominal cramps, myalgia, agitation,

palpitations, tachycardia, panic attacks, vertigo, hyperreflexia, short-term memory loss, and

hyperthermia. Convulsions/seizures may be more common in patients with pre-existing seizure

disorders or who are taking other drugs that lower the convulsive threshold such as antidepressants.

There is evidence that tolerance develops to the sedative effects of benzodiazepines.

Lorazepam may have abuse potential, especially in patients with a history of drug and/or alcohol abuse.

PRECAUTIONS

In patients with depression, a possibility for suicide should be borne in mind; benzodiazepines should

not be used in such patients without adequate antidepressant therapy.

Lorazepam should be used with caution in patients with compromised respiratory function (e.g., COPD,

sleep apnea syndrome).

Elderly or debilitated patients may be more susceptible to the sedative effects of lorazepam. Therefore,

these patients should be monitored frequently and have their dosage adjusted carefully according to

patient response; the initial dosage should not exceed 2 mg.

Paradoxical reactions have been occasionally reported during benzodiazepine use. Such reactions may

be more likely to occur in children and the elderly. Should these occur, use of the drug should be

discontinued.

The usual precautions for treating patients with impaired renal or hepatic function should be observed.

As with all benzodiazepines, the use of lorazepam may worsen hepatic encephalopathy; therefore,

lorazepam should be used with caution in patients with severe hepatic insufficiency and/or

encephalopathy. Dosage for patients with severe hepatic insufficiency should be adjusted carefully

according to patient response; lower doses may be sufficient in such patients.

In patients where gastrointestinal or cardiovascular disorders coexist with anxiety, it should be noted

that lorazepam has not been shown to be of significant benefit in treating the gastrointestinal or

cardiovascular component.

Esophageal dilation occurred in rats treated with lorazepam for more than one year at 6 mg/kg/day. The

no-effect dose was 1.25 mg/kg/day (approximately 6 times the maximum human therapeutic dose of 10

mg per day). The effect was reversible only when the treatment was withdrawn within two months of

first observation of the phenomenon. The clinical significance of this is unknown. However, use of

lorazepam for prolonged periods and in geriatric patients requires caution, and there should be frequent

monitoring for symptoms of upper G.I. disease.

Safety and effectiveness of lorazepam in children of less than 12 years have not been established.

Information for Patients

To assure the safe and effective use of lorazepam, patients should be informed that, since

benzodiazepines may produce psychological and physical dependence, it is advisable that they consult

with their physician before either increasing the dose or abruptly discontinuing this drug.

Essential Laboratory Tests

Some patients on lorazepam have developed leukopenia, and some have had elevations of LDH. As with

other benzodiazepines, periodic blood counts and liver function tests are recommended for patients on

long-term therapy.

Clinically Significant Drug Interactions

The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression

because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines

interact at GABAA sites and opioids interact primarily at mu receptors. When benzodiazepines and

opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related

respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and

opioids, and monitor patients closely for respiratory depression and sedation.

The benzodiazepines, including Lorazepam, produce increased CNS-depressant effects when

administered with other CNS depressants such as alcohol, barbiturates, antipsychotics,

sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines,

anticonvulsants, and anesthetics.

Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation,

hypotension, ataxia, delirium, and respiratory arrest.

Concurrent administration of lorazepam with valproate results in increased plasma concentrations and

reduced clearance of lorazepam. Lorazepam dosage should be reduced to approximately 50% when

coadministered with valproate.

Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged

effect of lorazepam due to increased half-life and decreased total clearance. Lorazepam dosage needs

to be reduced by approximately 50% when coadministered with probenecid.

The effects of probenecid and valproate on lorazepam may be due to inhibition of glucuronidation.

Administration of theophylline or aminophylline may reduce the sedative effects of

benzodiazepines, including lorazepam.

Carcinogenesis and Mutagenesis

No evidence of carcinogenic potential emerged in rats during an 18-month study with lorazepam. No

studies regarding mutagenesis have been performed.

Pregnancy

Reproductive studies in animals were performed in mice, rats, and two strains of rabbits. Occasional

anomalies (reduction of tarsals, tibia, metatarsals, malrotated limbs, gastroschisis, malformed skull, and

microphthalmia) were seen in drug-treated rabbits without relationship to dosage. Although all of these

anomalies were not present in the concurrent control group, they have been reported to occur randomly

in historical controls. At doses of 40 mg/kg and higher, there was evidence of fetal resorption and

increased fetal loss in rabbits which was not seen at lower doses.

The clinical significance of the above findings is not known. However, an increased risk of congenital

malformations associated with the use of minor tranquilizers (chlordiazepoxide, diazepam, and

meprobamate) during the first trimester of pregnancy has been suggested in several studies. Because the

use of these drugs is rarely a matter of urgency, the use of lorazepam during this period should be

avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution

of therapy should be considered. Patients should be advised that if they become pregnant, they should

communicate with their physician about the desirability of discontinuing the drug.

In humans, blood levels obtained from umbilical cord blood indicate placental transfer of lorazepam and

lorazepam glucuronide. Infants of mothers who ingested benzodiazepines for several weeks or more

preceding delivery have been reported to have withdrawal symptoms during the postnatal period.

Symptoms such as hypoactivity, hypotonia, hypothermia, respiratory depression, apnea, feeding

problems, and impaired metabolic response to cold stress have been reported in neonates born of

mothers who have received benzodiazepines during the late phase of pregnancy or at delivery.

Nursing Mothers

Lorazepam has been detected in human breast milk; therefore, it should not be administered to

breastfeeding women, unless the expected benefit to the woman outweighs the potential risk to the

infant.

Sedation and inability to suckle have occurred in neonates of lactating mothers taking benzodiazepines.

Infants of lactating mothers should be observed for pharmacological effects (including sedation and

irritability).

Geriatric Use

Clinical studies of lorazepam generally were not adequate to determine whether subjects aged 65 and

over respond differently than younger subjects; however, the incidence of sedation and unsteadiness

was observed to increase with age (see ADVERSE REACTIONS).

Age does not appear to have a significant effect on lorazepam kinetics (see CLINICAL

PHARMACOLOGY).

Clinical circumstances, some of which may be more common in the elderly, such as hepatic or renal

impairment, should be considered. Greater sensitivity (e.g., sedation) of some older individuals cannot

be ruled out. In general, dose selection for an elderly patient should be cautious, and lower doses may

be sufficient in these patients (see DOSAGE AND ADMINISTRATION).

ADVERSE REACTIONS

Most adverse reactions to benzodiazepines, including CNS effects and respiratory depression, are dose

dependent, with more severe effects occurring with high doses.

In a sample of about 3500 patients treated for anxiety, the most frequent adverse reaction to lorazepam

was sedation (15.9%), followed by dizziness (6.9%), weakness (4.2%), and unsteadiness (3.4%). The

incidence of sedation and unsteadiness increased with age.

Other adverse reactions to benzodiazepines, including lorazepam are fatigue, drowsiness, amnesia,

memory impairment, confusion, disorientation, depression, unmasking of depression, disinhibition,

euphoria, suicidal ideation/attempt, ataxia, asthenia, extrapyramidal symptoms, convulsions/seizures

tremor, vertigo, eye-function/visual disturbance (including diplopia and blurred vision),

dysarthria/slurred speech, change in libido, impotence, decreased orgasm; headache, coma; respiratory

depression, apnea, worsening of sleep apnea, worsening of obstructive pulmonary disease;

gastrointestinal symptoms including nausea, change in appetite, constipation, jaundice, increase in

bilirubin, increase in liver transaminases, increase in alkaline phosphatase; hypersensitivity reactions,

anaphylacticoid reactions; dermatological symptoms, allergic skin reactions, alopecia; SIADH,

hyponatremia; thrombocytopenia, agranulocytosis, pancytopenia; hypothermia; and autonomic

manifestations.

Paradoxical reactions, including anxiety, excitation, agitation, hostility, aggression, rage, sleep

disturbances/insomnia, sexual arousal, and hallucinations may occur. Small decreases in blood pressure

and hypotension may occur but are usually not clinically significant, probably being related to the relief

of anxiety produced by lorazepam.

OVERDOSAGE

In postmarketing experience, overdose with lorazepam has occurred predominantly in combination with

alcohol and/or other drugs. Therefore, in the management of overdosage, it should be borne in mind that

multiple agents may have been taken.

Symptoms

Overdosage of benzodiazepines is usually manifested by varying degrees of central nervous system

depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, mental

confusion, paradoxical reactions, dysarthria and lethargy. In more serious cases, and especially when

other drugs or alcohol were ingested, symptoms may include ataxia, hypotonia, hypotension,

cardiovascular depression, respiratory depression, hypnotic state, coma, and death.

Management

General supportive and symptomatic measures are recommended; vital signs must be monitored and the

patient closely observed. When there is a risk of aspiration, induction of emesis is not recommended.

Gastric lavage may be indicated if performed soon after ingestion or in symptomatic patients.

Administration of activated charcoal may also limit drug absorption. Hypotension, though unlikely,

usually may be controlled with norepinephrine bitartrate injection. Lorazepam is poorly dialyzable.

Lorazepam glucuronide, the inactive metabolite, may be highly dialyzable.

The benzodiazepine antagonist flumazenil may be used in hospitalized patients as an adjunct to, not as a

substitute for, proper management of benzodiazepine overdose. The prescriber should be aware of a

risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine

users and in cyclic antidepressant overdose. The complete flumazenil package insert including

CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS should be consulted prior to use.

DOSAGE AND ADMINISTRATION

Lorazepam tablets are administered orally. For optimal results, dose, frequency of administration, and

duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1

mg, and 2 mg tablets are available.

The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime,

but the daily dosage may vary from 1 to 10 mg/day.

For anxiety, most patients require an initial dose of 2 to 3 mg/day given b.i.d. or t.i.d.

For insomnia due to anxiety or transient situational stress, a single daily dose of 2 mg to 4 mg may be

given, usually at bedtime.

For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended,

to be adjusted as needed and tolerated.

The dosage of lorazepam tablets should be increased gradually when needed to help avoid adverse

effects. When higher dosage is indicated, the evening dose should be increased before the daytime

doses.

HOW SUPPLIED

1 mg, white to off-white, round, flat-faced beveled edge tablets debossed with U33 on one side and

bisect on other side.

NDC 68071-5022-5 BOTTLES OF 15

DISPENSE IN A TIGHT, LIGHT-RESISTANT CONTAINER AS DESCRIBED IN THE USP.

STORE AT 20°C to 25°C (68°to 77°F). [SEE USP CONTROLLED ROOM TEMPERATURE.]

Manufactured by:

Aurolife Pharma LLC

Dayton, NJ 08810

Manufactured for:

Aurobindo Pharma USA, Inc.

Dayton, NJ 08810

Revised:11/2017

MEDICATION GUIDE

LORAZEPAM Tablets, USP CIV

What is the most important information I should know about LORAZEPAM?

LORAZEPAM is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines,

alcohol, or other central nervous system depressants (including street drugs) can cause severe

drowsiness, breathing problems (respiratory depression), coma and death.

LORAZEPAM can make you sleepy or dizzy, and can slow your thinking and motor skills.

o Do not drive, operate heavy machinery, or do other dangerous activities until you know how

LORAZEPAM affects you.

o Do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking

LORAZEPAM without first talking to your healthcare provider. When taken with alcohol or drugs that

cause sleepiness or dizziness, LORAZEPAM may make your sleepiness or dizziness much worse.

Do not take more LORAZEPAM than prescribed.

What is LORAZEPAM?

LORAZEPAM is a prescription medicine used:

o to treat anxiety disorders

o for the short-term relief of the symptoms of anxiety or anxiety that can happen with symptoms of

depression

LORAZEPAM is a federal controlled substance (C-IV) because it can be abused or lead to

dependence. Keep LORAZEPAM in a safe place to prevent misuse and abuse. Selling or giving away

LORAZEPAM may harm others, and is against the law. Tell your healthcare provider if you have

abused or been dependent on alcohol, prescription medicines or street drugs.

It is not known if LORAZEPAM is safe and effective in children less than 12 years of age.

It is not known if LORAZEPAM is safe and effective for use for longer than 4 months.

Do not take LORAZEPAM if you:

are allergic to lorazepam, other benzodiazepines, or any of the ingredients in LORAZEPAM. See

the end of this Medication Guide for a complete list of ingredients in LORAZEPAM.

Before you take LORAZEPAM, tell your healthcare provider about all of your medical

conditions, including if you:

have or have had depression, mood problems, or suicidal thoughts or behavior

have a history of drug or alcohol abuse or addiction

have lung disease or breathing problems (such as COPD, sleep apnea syndrome)

have liver or kidney problems

have or have had seizures

are pregnant or plan to become pregnant. LORAZEPAM may harm your unborn baby. You and your

healthcare provider should decide if you should take LORAZEPAM while you are pregnant.

are breastfeeding or plan to breastfeed. LORAZEPAM passes into your breast milk and may harm

your baby. Talk to your healthcare provider about the best way to feed your baby if you take

LORAZEPAM. You should not breastfeed while taking LORAZEPAM

Tell your healthcare provider about all the medicines you take, including prescription and over-the-

counter medicines, vitamins, and herbal supplements.

Taking LORAZEPAM with certain other medicines can cause side effects or affect how well

LORAZEPAM or the other medicines work. Do not start or stop other medicines without talking to your

healthcare provider.

How should I take LORAZEPAM?

Take LORAZEPAM exactly as your healthcare provider tells you to take it. Your healthcare

provider will tell you how much LORAZEPAM to take and when to take it.

If you take too much LORAZEPAM, call your healthcare provider or go to the nearest hospital

emergency room right away.

What should I avoid while taking LORAZEPAM?

LORAZEPAM can cause you to be drowsy. Do not drive a car or operate heavy machinery until you

know how LORAZEPAM affects you.

You should not drink alcohol while taking LORAZEPAM. Drinking alcohol can increase your

chances of having serious side effects.

What are the possible side effects of LORAZEPAM?

LORAZEPAM may cause serious side effects, including:

See “What is the most important information I should know about LORAZEPAM?”

Depression. Pre-existing depression may emerge or worsen during use of benzodiazepines

including LORAZEPAM.

Abuse and dependence. Taking LORAZEPAM can cause physical and psychological dependence.

Physical and psychological dependence is not the same as drug addiction. Your healthcare provider

can tell you more about the differences between physical and psychological dependence and drug

addiction.

Withdrawal symptoms. You may have withdrawal symptoms if you stop taking LORAZEPAM

suddenly.

Withdrawal symptoms can be serious and include seizures. Mild withdrawal symptoms include a

depressed mood and trouble sleeping. Talk to your healthcare provider about slowly stopping

LORAZEPAM to avoid withdrawal symptoms.

The most common side effects of LORAZEPAM include:

sedation dizziness

weakness unsteadiness

These are not all the possible side effects of LORAZEPAM. Call your doctor for medical advice about

side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store LORAZEPAM?

Store LORAZEPAM in a tightly closed container at 77°F (25°C); excursions permitted to 59° to

86°F (15° to 30°C).

Keep LORAZEPAM and all medicines out of the reach of children.

Keep LORAZEPAM and all medicines out of the reach of children.

General information about the safe and effective use of LORAZEPAM.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not

use LORAZEPAM for a condition for which it was not prescribed. Do not give LORAZEPAM to other

people, even if they have the same symptoms that you have. It may harm them. You can ask your

pharmacist or healthcare provider for information about LORAZEPAM that is written for health

professionals.

What are the ingredients in LORAZEPAM?

Active ingredient: lorazepam

Inactive ingredients: anhydrous lactose, magnesium stearate, and microcrystalline cellulose and

polacrilin potassium.

This Medication Guide has been approved by the U.S. Food and Drug Administration

Manufactured by:

Aurolife Pharma LLC

Dayton, NJ 08810

Manufactured for:

Aurobindo Pharma USA, Inc.

Dayton, NJ 08810

Revised:11/2017

PACKAGE LABEL-PRINCIPAL DISPLAY PANEL –

LORAZEPAM

lorazepam tablet

Product Information

Product T ype

HUMAN

PRESCRIPTION DRUG

Ite m Code (Source )

NDC:6 8 0 71-

50 22(NDC:1310 7-0 8 4)

Route of Administration

ORAL

DEA Sche dule

Active Ingredient/Active Moiety

Ingredient Name

Basis of Strength

Stre ng th

LO RAZEPAM (UNII: O26 FZP76 9 L) (LORAZEPAM - UNII:O26 FZP76 9 L)

LORAZEPAM

1 mg

Inactive Ingredients

Ingredient Name

Stre ng th

ANHYDRO US LACTO SE (UNII: 3SY5LH9 PMK)

MAGNESIUM STEARATE (UNII: 70 0 9 7M6 I30 )

CELLULO SE, MICRO CRYSTALLINE (UNII: OP1R32D6 1U)

PO LACRILIN PO TASSIUM (UNII: 0 BZ5A0 0 FQU)

Product Characteristics

Color

white (White to o ff white)

S core

2 pieces

S hap e

ROUND (Flat-faced beveled edge)

S iz e

Flavor

Imprint Code

Contains

Packag ing

#

Item Code

Package Description

Marketing Start Date

Marketing End Date

1

NDC:6 8 0 71-50 22-5

15 in 1 BOTTLE; Type 0 : No t a Co mbinatio n Pro duct

0 8 /0 8 /20 19

NuCare Pharmaceuticals,Inc.

Marketing Information

Marke ting Cate gory

Application Numbe r or Monograph Citation

Marke ting Start Date

Marke ting End Date

ANDA

ANDA20 3572

0 3/24/20 17

Labeler -

NuCare Pharmaceuticals,Inc. (010632300)

Establishment

Name

Ad d re s s

ID/FEI

Busine ss Ope rations

NuCare Pharmaceuticals,Inc.

0 10 6 3230 0

re pa c k(6 8 0 71-50 22)

Revised: 8/2019

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