LISINOPRIL RANBAXY

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Lisinopril dihydrate

Available from:

Ranbaxy Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

 
Lisinopril Ranbaxy CMI V1 Feb 2009

Page 1 
LISINOPRIL RANBAXY 

LISINOPRIL DIHYDRATE_ _
CONSUMER MEDICINE INFORMATION 

WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about 
LISINOPRIL RANBAXY.  

It does not contain all the 
available information. It does not 
take the place of talking to your 
doctor or pharmacist.  

All medicines have risks and 
benefits. Your doctor has 
weighed the risks of you taking 
LISINOPRIL RANBAXY against the 
benefits it is expected to have for 
you.  

IF YOU HAVE ANY CONCERNS 
ABOUT TAKING THIS MEDICINE, 
ASK YOUR DOCTOR OR 
PHARMACIST.  

KEEP THIS LEAFLET WITH THE 
MEDICINE.  
You may need to read it again.  

WHAT LISINOPRIL 
RANBAXY IS USED FOR 

LISINOPRIL RANBAXY_ _is used to: 
  lower high blood pressure 
(hypertension) 
  treat heart failure 
  treat patients who have just 
had a heart attack 

HYPERTENSION: 
Everyone has blood pressure. 
This pressure helps get your 
blood all around your body.  

Your blood pressure may be 
different at different times of the 
day, depending on how busy or 
worried you are. You have 
hypertension (high blood 
pressure) when your blood 
pressure stays higher than is 
needed, even when you are 
calm and relaxed.  

There are usually no symptoms 
of hypertension. The only way of 
knowing that you have 
hypertension is to have your 
blood pressure checked on a 
regular basis. If high blood 
pressure is not treated it can 
lead to serious health problems, 
including stroke, heart disease 
and kidney failure. 

LISINOPRIL RANBAXY is used to 
lower high blood pressure 
(hypertension).  

HEART FAILURE: 
Heart failure means that the 
heart muscle cannot pump blood 
strongly enough to supply all the 
blood needed throughout the 
body. Heart failure is not the 
same as heart attack and does 
not mean that the heart stops 
working.  

Heart failure may start off with 
no sy

Summary of Product characteristics

LISINOPRIL RANBAXY PI V1 Apr 09 
Page 1 
LISINOPRIL RANBAXY TABLETS 

NAME OF THE DRUG 
Active Ingredient:_ _
Lisinopril dihydrate. 

Inactive Ingredients: 
Mannitol, calcium hydrogen phosphate, Maize starch, Pregelatinised maize 
starch, magnesium stearate. 

All strengths  also contain iron oxide yellow (CI77492), while
the 20 mg tablet 
also contains iron oxide red (CI77491) 

DESCRIPTION 
Chemical Name:  
_N_-[_N_-[(1_S_)-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline
dihydrate 

Chemical Structure: 
_ _
_ _
_ _
_ _
Molecular Formula:  
C
21
H
31
N
3
O
5
.2H
2
O  

Molecular Weight: 
441.53  

CAS Number: 

83915-83-7_ _

A synthetic peptide derivative, lisinopril dihydrate
is an oral long-acting angiotensin converting enzyme 
inhibitor. It is a lysine analogue
of enalaprilat (active metabolite of enalapril).  

Lisinopril dihydrate is a white to off-white crystalline powder that is soluble in water, sparingly soluble in 
methanol and practically insoluble in ethanol. 

PHARMACOLOGY  
MECHANISM OF ACTION_  _
Lisinopril is a
peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that 
catalyses the conversion of angiotensin
I to the vasoconstrictor substance, angiotensin ll. Angiotensin 
ll also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased 
concentrations of plasma angiotensin  ll which results in decreased vasopressor activity and to 
decreased aldosterone secretion. The latter decrease may result in a small increase of serum 
potassium. In hypertensive patients with normal renal function
treated with lisinopril alone for up to 
24 weeks, the mean increase in
serum potassium was approximately 0.1 mmol/L; however, 
approximately 15% of patients had increases greater than 0.5 mmol/L and approx