LIFE LINCO-SPEC PREMIX

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

Lincomycin Hydrochloride (monohydrate); Spectinomycin Sulfate (tetrahydrate)

Available from:

Life Biopharma Sdn. Bhd.

INN (International Name):

Lincomycin Hydrochloride (monohydrate); Spectinomycin Sulfate (tetrahydrate)

Units in package:

25 kg

Manufactured by:

Life Biopharma Sdn. Bhd.

Summary of Product characteristics

LIFE LINCO-SPECTIN 4.4% PREMIX
1
FOR ANIMAL USE ONLY
PRODUCT NAME :
LIFE LINCO-SPEC PREMIX
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
Each g contains Lincomycin 22 mg (equivalent to Lincomycin
Hydrochloride Monohydrate 24.95 mg) and Spectinomycin 22 mg
(equivalent to Spectinomycin Sulfate Tetrahydrate 33.26 mg).
PRODUCT DESCRIPTION
A white or off-white powder for use in animal feed.
TARGET SPECIES
Pigs.
PHARMACODYNAMICS
Lincomycin is a lincosamide antibiotic and is produced by
_Streptococcus lincolnensis_. The mode of action of lincomycin is
inhibition of protein synthesis at the ribosomal 50S sub-unit level.
Lincomycin is
largely used in pigs to control dysentery and mycoplasma infections.
Spectinomycin is an aminocyclitol antibiotic that is produced by
_Streptomyces spectabilis_. The mode of action of spectinomycin is
inhibition of protein synthesis via a 30S ribosomal target. It is a
broad-
spectrum drug with activity against gram-positive and some
gram-negative bacteria, but little anaerobic activity. It has good
activity against Mycoplasma.
Lincomycin and spectinomycin combination have been shown to be
synergistic in vitro against mycoplasma.
PHARMACOKINETICS
Lincomycin is rapidly but incompletely absorbed when administered
orally to animals. Lincomycin is well distributed in the body, with
highest tissue concentration in the liver and kidneys, while very low
levels
are obtained in the CSF. Lincomycin can pass unchanged from the body
via the bile and feces or urine or can be metabolized to the
glucuronide, N-demthyl lincomycin, or licomycin sulfoxide forms by the
liver.
Spectinomycin has a small volume of distribution. It is poorly
absorbed following oral administration. Most of an oral dose is
eliminated in the feces. Oral administration has been used for a local
effect for
treatment of diarrhea.
TARGET SPECIES
Pigs
INDICATIONS
For the treatment and control of swine dysentery (Vibrionic dysentery,
bloody scours); salmonellosis (necrotic enteritis); enteritis
associated with_ E. coli _and as an aid in control