LEADER STOCK MARKER SPRAY

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

Buy It Now

Active ingredient:
HYDROCARBON LIQUID
Available from:
DY-MARK (AUST.) PTY. LTD.
INN (International Name):
Undefined
Pharmaceutical form:
TOPICAL AEROSOL SPRAY
Composition:
HYDROCARBON LIQUID SOLVENT Other 523.0 g/kg
Units in package:
200g
Class:
VP - Veterinary Pesticide
Manufactured by:
DY-MARK (AUST.)
Therapeutic group:
STOCK
Therapeutic area:
MISCELLANEOUS VETERINARY
Therapeutic indications:
DYE MARKER
Product summary:
Poison schedule: 5; Withholding period: WHP:N/A; Host/pest details: STOCK: [DYE MARKER]; Poison schedule: 5; Withholding period: ; Host/pest details: STOCK: [DYE MARKER]; Scourable durable colour identification.
Authorization status:
Registered
Authorization number:
53270
Authorization date:
2020-07-01

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DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 1 of 34

Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

PROPER SHIPPING NAME

AEROSOLS

PRODUCT USE

■Application is by spray atomisation from a hand held aerosol pack.

Used according to manufacturer's directions.

SUPPLIER

Company:Dy-MarkPtyLtd

Address:

89FormationStreet

Wacol

QLD,4076

Australia

Telephone:+61732712222

Fax:+61732712751

Email:info@dymark.com.au

Section 2 - HAZARDS IDENTIFICATION

STATEMENT OF HAZARDOUS NATURE

HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to NOHSC Criteria, and ADG Code.

CHEMWATCH HAZARD RATINGS

Flammability

Toxicity

Body Contact

Reactivity

Chronic

SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4

RISK SAFETY

■Extremelyflammable. ■Keeplockedup.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 2 of 34

Section 2 - HAZARDS IDENTIFICATION

■Irritatingtoeyes. ■Keepawayfromsourcesofignition.Nosmoking.

■Riskofexplosionifheatedunder ■Donotbreathegas/fumes/vapour/spray.

confinement.

■Harmfultoaquaticorganisms,maycause ■Incaseofinsufficientventilation,wear

long-termadverseeffectsintheaquatic suitablerespiratoryequipment.

environment.

■Maycauseharmtotheunbornchild. ■Useonlyinwellventilatedareas.

■Repeatedexposuremaycauseskindrynessand ■Keepcontainerinawellventilatedplace.

cracking.

■Vapoursmaycausedrowsinessanddizziness. ■Avoidexposure-obtainspecialinstructions

beforeuse.

■Inhalation,skincontactand/oringestion ■Tocleanthefloorandallobjectscontaminated

mayproducehealthdamage*. bythismaterial,usewateranddetergent.

■Cumulativeeffectsmayresultfollowing ■Keepcontainertightlyclosed.

exposure*.

■Mayproducediscomfortoftherespiratory ■Thismaterialanditscontainermustbedisposed

systemandskin*. ofinasafeway.

*(limitedevidence). ■Keepawayfromfood,drinkandanimalfeeding

stuffs.

■Incaseofcontactwitheyes,rinsewithplenty

ofwaterandcontactDoctororPoisonsInformation

Centre.

■Thismaterialanditscontainermustbedisposed

ofashazardouswaste.

Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS

NAME CAS RN %

ethanol 64-17-5 20-40

acetone 67-64-1 10-30

propylene glycol monomethyl ether - alpha isomer 107-98-2 <1

dibutyl phthalate 84-74-2 <1

resin, non- hazardous 1-10

dimethyl ether 115-10-6 30-60

Section 4 - FIRST AID MEASURES

SWALLOWED

Not considered a normal route of entry.

If spontaneous vomiting appears imminent or occurs, hold patient's head down, lower than their hips to help

avoid possible aspiration of vomitus.

EYE

■If aerosols come in contact with the eyes:

Immediately hold the eyelids apart and flush the eye continuously for at least 15 minutes with fresh

running water.

Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by

occasionally lifting the upper and lower lids.

Transport to hospital or doctor without delay.

Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 3 of 34

Section 4 - FIRST AID MEASURES

SKIN

■If solids or aerosol mists are deposited upon the skin:

Flush skin and hair with running water (and soap if available).

Remove any adhering solids with industrial skin cleansing cream.

DO NOT use solvents.

Seek medical attention in the event of irritation.

INHALED

■If aerosols, fumes or combustion products are inhaled:

Remove to fresh air.

Lay patient down. Keep warm and rested.

Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to

initiating first aid procedures.

If breathing is shallow or has stopped, ensure clear airway and apply resuscitation, preferably with a

demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.

Transport to hospital, or doctor.

NOTES TO PHYSICIAN

■Treatsymptomatically.

forloweralkylethers:

--------------------------------------------------------------

BASICTREATMENT

--------------------------------------------------------------

Establishapatentairwaywithsuctionwherenecessary.

Watchforsignsofrespiratoryinsufficiencyandassistventilationasnecessary.

Administeroxygenbynon-rebreathermaskat10to15l/min.

Alow-stimulusenvironmentmustbemaintained.

Monitorandtreat,wherenecessary,forshock.

Anticipateandtreat,wherenecessary,forseizures.

DONOTuseemetics.Whereingestionissuspectedrinsemouthandgiveupto200mlwater(5ml/kg

recommended)fordilutionwherepatientisabletoswallow,hasastronggagreflexanddoesnotdrool.

--------------------------------------------------------------

ADVANCEDTREATMENT

--------------------------------------------------------------

Considerorotrachealornasotrachealintubationforairwaycontrolinunconsciouspatientorwhere

respiratoryarresthasoccurred.

Positive-pressureventilationusingabag-valvemaskmightbeofuse.

Monitorandtreat,wherenecessary,forarrhythmias.

StartanIVD5WTKO.IfsignsofhypovolaemiaarepresentuselactatedRingerssolution.Fluidoverload

mightcreatecomplications.

Drugtherapyshouldbeconsideredforpulmonaryoedema.

Hypotensionwithoutsignsofhypovolaemiamayrequirevasopressors.

Treatseizureswithdiazepam.

Proparacainehydrochlorideshouldbeusedtoassisteyeirrigation.

--------------------------------------------------------------

EMERGENCYDEPARTMENT

--------------------------------------------------------------

Laboratoryanalysisofcompletebloodcount,serumelectrolytes,BUN,creatinine,glucose,urinalysis,

baselineforserumaminotransferases(ALTandAST),calcium,phosphorusandmagnesium,mayassistin

establishingatreatmentregime.Otherusefulanalysesincludeanionandosmolargaps,arterialbloodgases

(ABGs),chestradiographsandelectrocardiograph.

Ethersmayproduceaniongapacidosis.Hyperventilationandbicarbonatetherapymightbeindicated.

Haemodialysismightbeconsideredinpatientswithimpairedrenalfunction.

Consultatoxicologistasnecessary.

BRONSTEIN,A.C.andCURRANCE,P.L.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 4 of 34

Section 4 - FIRST AID MEASURES

EMERGENCYCAREFORHAZARDOUSMATERIALSEXPOSURE:2ndEd.1994.

Foracuteorshorttermrepeatedexposurestoacetone:

Symptomsofacetoneexposureapproximateethanolintoxication.

About20%isexpiredbythelungsandtherestismetabolised.Alveolarairhalf-lifeisabout4hours

followingtwohourinhalationatlevelsneartheExposureStandard;inoverdose,saturablemetabolismand

limitedclearance,prolongtheeliminationhalf-lifeto25-30hours.

Therearenoknownantidotesandtreatmentshouldinvolvetheusualmethodsofdecontaminationfollowedby

supportivecare.[EllenhornandBarceloux:MedicalToxicology]

Management:

Measurementofserumandurineacetoneconcentrationsmaybeusefultomonitortheseverityofingestionor

inhalation.

InhalationManagement:

Maintainaclearairway,givehumidifiedoxygenandventilateifnecessary.

Ifrespiratoryirritationoccurs,assessrespiratoryfunctionand,ifnecessary,performchestX-raysto

checkforchemicalpneumonitis.

Considertheuseofsteroidstoreducetheinflammatoryresponse.

TreatpulmonaryoedemawithPEEPorCPAPventilation.

DermalManagement:

Removeanyremainingcontaminatedclothing,placeindoublesealed,clearbags,labelandstoreinsecure

areaawayfrompatientsandstaff.

Irrigatewithcopiousamountsofwater.

Anemollientmayberequired.

EyeManagement:

Irrigatethoroughlywithrunningwaterorsalinefor15minutes.

Stainwithfluoresceinandrefertoanophthalmologistifthereisanyuptakeofthestain.

OralManagement:

NoGASTRICLAVAGEOREMETIC

Encourageoralfluids.

SystemicManagement:

MonitorbloodglucoseandarterialpH.

Ventilateifrespiratorydepressionoccurs.

Ifpatientunconscious,monitorrenalfunction.

Symptomaticandsupportivecare.

TheChemicalIncidentManagementHandbook:

Guy'sandSt.Thomas'HospitalTrust,2000

BIOLOGICALEXPOSUREINDEX

Theserepresentthedeterminantsobservedinspecimenscollectedfromahealthyworkerexposedatthe

ExposureStandard(ESorTLV):

Determinant SamplingTime Index Comments

Acetoneinurine Endofshift 50mg/L NS

NS:Non-specificdeterminant;alsoobservedafterexposuretoothermaterial.

Foracuteorshorttermrepeatedexposurestoethanol:

Acuteingestioninnon-tolerantpatientsusuallyrespondstosupportivecarewithspecialattentionto

preventionofaspiration,replacementoffluidandcorrectionofnutritionaldeficiencies(magnesium,

thiaminepyridoxine,VitaminsCandK).

Give50%dextrose(50-100ml)IVtoobtundedpatientsfollowingblooddrawforglucosedetermination.

Comatosepatientsshouldbetreatedwithinitialattentiontoairway,breathing,circulationanddrugsof

immediateimportance(glucose,thiamine).

Decontaminationisprobablyunnecessarymorethan1hourafterasingleobservedingestion.Catharticsand

charcoalmaybegivenbutareprobablynoteffectiveinsingleingestions.

Fructoseadministrationiscontra-indicatedduetosideeffects.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 5 of 34

Section 5 - FIRE FIGHTING MEASURES

EXTINGUISHING MEDIA

Alcoholstablefoam.

Drychemicalpowder.

BCF(whereregulationspermit).

Carbondioxide.

Watersprayorfog-Largefiresonly.

SMALLFIRE:

Waterspray,drychemicalorCO2

LARGEFIRE:

Watersprayorfog.

FIRE FIGHTING

■FORFIRESINVOLVINGMANYGASCYLINDERS:

Tostoptheflowofgas,specificallytrainedpersonnelmayinerttheatmospheretoreduceoxygenlevels

thusallowingthecappingofleakingcontainer(s).

Reducetherateofflowandinjectaninertgas,ifpossible,beforecompletelystoppingtheflowto

preventflashback.

DONOTextinguishthefireuntilthesupplyisshutoffotherwiseanexplosivere-ignitionmayoccur.

Ifthefireisextinguishedandtheflowofgascontinues,usedincreasedventilationtopreventbuild-up,

ofexplosiveatmosphere.

Usenon-sparkingtoolstoclosecontainervalves.

BeCAUTIOUSofaBoilingLiquidEvaporatingVapourExplosion,BLEVE,iffireisimpingingonsurrounding

containers.

Direct2500litre/min(500gpm)waterstreamontocontainersaboveliquidlevelwiththeassistanceremote

monitors.

AlertFireBrigadeandtellthemlocationandnatureofhazard.

Maybeviolentlyorexplosivelyreactive.

Wearbreathingapparatusplusprotectivegloves.

Prevent,byanymeansavailable,spillagefromenteringdrainsorwatercourse.

Ifsafe,switchoffelectricalequipmentuntilvapourfirehazardremoved.

Usewaterdeliveredasafinespraytocontrolfireandcooladjacentarea.

DONOTapproachcontainerssuspectedtobehot.

Coolfireexposedcontainerswithwatersprayfromaprotectedlocation.

Ifsafetodoso,removecontainersfrompathoffire.

Equipmentshouldbethoroughlydecontaminatedafteruse.

FIRE/EXPLOSION HAZARD

Liquidandvapourarehighlyflammable.

Severefirehazardwhenexposedtoheatorflame.

Vapourformsanexplosivemixturewithair.

Severeexplosionhazard,intheformofvapour,whenexposedtoflameorspark.

Vapourmaytravelaconsiderabledistancetosourceofignition.

Heatingmaycauseexpansionordecompositionwithviolentcontainerrupture.

Aerosolcansmayexplodeonexposuretonakedflames.

Rupturingcontainersmayrocketandscatterburningmaterials.

Hazardsmaynotberestrictedtopressureeffects.

Mayemitacrid,poisonousorcorrosivefumes.

Oncombustion,mayemittoxicfumesofcarbonmonoxide(CO).

Combustionproductsinclude:carbonmonoxide(CO),carbondioxide(CO2),otherpyrolysisproductstypicalof

burningorganicmaterial.

Containslowboilingsubstance:Closedcontainersmayruptureduetopressurebuildupunderfireconditions.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 6 of 34

Section 5 - FIRE FIGHTING MEASURES

FIRE INCOMPATIBILITY

Avoidcontaminationwithoxidisingagentsi.e.nitrates,oxidisingacids,chlorinebleaches,poolchlorine

etc.asignitionmayresult.

HAZCHEM

Personal Protective Equipment

Breathing apparatus.

Gas tight chemical resistant suit.

Limit exposure duration to 1 BA set 30 mins.

Section 6 - ACCIDENTAL RELEASE MEASURES

MINOR SPILLS

Cleanupallspillsimmediately.

Avoidbreathingvapoursandcontactwithskinandeyes.

Wearprotectiveclothing,imperviousglovesandsafetyglasses.

Shutoffallpossiblesourcesofignitionandincreaseventilation.

Wipeup.

Ifsafe,damagedcansshouldbeplacedinacontaineroutdoors,awayfromallignitionsources,until

pressurehasdissipated.

Undamagedcansshouldbegatheredandstowedsafely.

MAJOR SPILLS

Aftercleanupoperations,decontaminateandlaunderallprotectiveclothingandequipmentbeforestoring

andre-using.

Removeleakingcylinderstoasafeplace.

Fitventpipes.Releasepressureundersafe,controlledconditions

Burnissuinggasatventpipes.

DONOTexertexcessivepressureonvalve;DONOTattempttooperatedamagedvalve.

Clearareaofpersonnelandmoveupwind.

AlertFireBrigadeandtellthemlocationandnatureofhazard.

Maybeviolentlyorexplosivelyreactive.

Wearbreathingapparatusplusprotectivegloves.

Prevent,byanymeansavailable,spillagefromenteringdrainsorwatercourses

Nosmoking,nakedlightsorignitionsources.

Increaseventilation.

Stopleakifsafetodoso.

Watersprayorfogmaybeusedtodisperse/absorbvapour.

Absorborcoverspillwithsand,earth,inertmaterialsorvermiculite.

Ifsafe,damagedcansshouldbeplacedinacontaineroutdoors,awayfromignitionsources,untilpressure

hasdissipated.

Undamagedcansshouldbegatheredandstowedsafely.

Collectresiduesandsealinlabelleddrumsfordisposal.

PROTECTIVE ACTIONS FOR SPILL

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 7 of 34

Section 6 - ACCIDENTAL RELEASE MEASURES

downwind distance

isolation

distance PROTECTIVE ACTION ZONE

evacuation

direction

evacuation

direction half

downwind

distance

half

downwind

distance INITIAL

ISOLATION

ZONE wind

direction

FromIERG(Canada/Australia)

IsolationDistance -

DownwindProtectionDistance 8metres

IERGNumber 49

FOOTNOTES

PROTECTIVEACTIONZONEisdefinedastheareainwhichpeopleareatriskofharmfulexposure.Thiszone

assumesthatrandomchangesinwinddirectionconfinesthevapourplumetoanareawithin30degreeson

eithersideofthepredominantwinddirection,resultinginacrosswindprotectiveactiondistanceequalto

thedownwindprotectiveactiondistance.

PROTECTIVEACTIONSshouldbeinitiatedtotheextentpossible,beginningwiththoseclosesttothespill

andworkingawayfromthesiteinthedownwinddirection.Withintheprotectiveactionzonealevelofvapour

concentrationmayexistresultinginnearlyallunprotectedpersonsbecomingincapacitatedandunabletotake

protectiveactionand/orincurringseriousorirreversiblehealtheffects.

INITIALISOLATIONZONEisdeterminedasanarea,includingupwindoftheincident,withinwhichahigh

probabilityoflocalisedwindreversalmayexposenearlyallpersonswithoutappropriateprotectiontolife-

threateningconcentrationsofthematerial.

SMALLSPILLSinvolvealeakingpackageof200litres(55USgallons)orless,suchasadrum(jerricanor

boxwithinnercontainers).Largerpackagesleakinglessthan200litresandcompressedgasleakingfroma

smallcylinderarealsoconsidered"smallspills".

LARGESPILLSinvolvemanysmallleakingpackagesoraleakingpackageofgreaterthan200litres,suchas

acargotank,portabletankora"one-tonne"compressedgascylinder.

Guide126istakenfromtheUSDOTemergencyresponseguidebook.

IERGinformationisderivedfromCANUTEC-TransportCanada.

Personal Protective Equipment advice is contained in Section 8 of the MSDS.

Section 7 - HANDLING AND STORAGE

PROCEDURE FOR HANDLING

Avoid all personal contact, including inhalation.

Wear protective clothing when risk of exposure occurs.

Use in a well-ventilated area.

Prevent concentration in hollows and sumps.

DO NOT enter confined spaces until atmosphere has been checked.

Avoid smoking, naked lights or ignition sources.

Avoid contact with incompatible materials.

When handling, DO NOT eat, drink or smoke.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 8 of 34

Section 7 - HANDLING AND STORAGE

DO NOT incinerate or puncture aerosol cans.

DO NOT spray directly on humans, exposed food or food utensils.

Avoid physical damage to containers.

Always wash hands with soap and water after handling.

Work clothes should be laundered separately.

Use good occupational work practice.

Observe manufacturer's storing and handling recommendations.

Atmosphere should be regularly checked against established exposure standards to ensure safe working

conditions are maintained.

SUITABLE CONTAINER

Aerosol dispenser.

Check that containers are clearly labelled.

STORAGE INCOMPATIBILITY

■Phthalates:

react with strong acids, strong oxidisers, permanganates and nitrates

attack some form of plastics.

Acetone:

may react violently with chloroform, activated charcoal, aliphatic amines, bromine, bromine trifluoride,

chlorotriazine, chromic(IV) acid, chromic(VI) acid, chromium trioxide, chromyl chloride, hexachloromelamine,

iodine heptafluoride, iodoform, liquid oxygen, nitrosyl chloride, nitrosyl perchlorate, nitryl perchlorate,

perchloromelamine, peroxomonosulfuric acid, platinum, potassium tert-butoxide, strong acids, sulfur

dichloride, trichloromelamine, xenon tetrafluoride

reacts violently with bromoform and chloroform in the presence of alkalies or in contact with alkaline

surfaces.

may form unstable and explosive peroxides in contact with strong oxidisers, fluorine, hydrogen peroxide

(90%), sodium perchlorate, 2-methyl-1,3-butadiene

can increase the explosive sensitivity of nitromethane on contact flow or agitation may generate

electrostatic charges due to low conductivity

dissolves or attacks most rubber, resins, and plastics (polyethylenes, polyester, vinyl ester, PVC,

Neoprene, Viton).

Ethers may react violently with strong oxidising agents and acids.

Ethers are generally stable to water under neutral conditions and ambient temperatures. The ether function

is hydrolysed by heating in the presence of halogen acids, particularly hydrogen iodide.

Ketones in this group:

are reactive with many acids and bases liberating heat and flammable gases (e.g., H2).

react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and

heat.

are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.

react violently with aldehydes, HNO3 (nitric acid), HNO3 + H2O2 (mixture of nitric acid and hydrogen

peroxide), and HClO4 (perchloric acid).

may react with hydrogen peroxide to form unstable peroxides; many are heat- and shock-sensitive explosives.

A significant property of most ketones is that the hydrogen atoms on the carbons next to the carbonyl group

are relatively acidic when compared to hydrogen atoms in typical hydrocarbons. Under strongly basic

conditions these hydrogen atoms may be abstracted to form an enolate anion. This property allows ketones,

especially methyl ketones, to participate in condensation reactions with other ketones and aldehydes. This

type of condensation reaction is favoured by high substrate concentrations and high pH (greater than 1 wt%

NaOH).

The tendency of many ethers to form explosive peroxides is well documented.

Ethers lacking non-methyl hydrogen atoms adjacent to the ether link are thought to be relatively safe.

When solvents have been freed from peroxides (by percolation through a column of activated alumina for

example), the absorbed peroxides must promptly be desorbed by treatment with the polar solvents methanol or

water, which should be discarded safely.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 9 of 34

Section 7 - HANDLING AND STORAGE

Avoid oxidising agents, acids, acid chlorides, acid anhydrides, chloroformates.

Avoid strong bases.

Compressed gases may contain a large amount of kinetic energy over and above that potentially available

from the energy of reaction produced by the gas in chemical reaction with other substances.

STORAGE REQUIREMENTS

Keep dry to avoid corrosion of cans. Corrosion may result in container perforation and internal pressure

may eject contents of can.

Store in original containers in approved flammable liquid storage area.

DO NOT store in pits, depressions, basements or areas where vapours may be trapped.

No smoking, naked lights, heat or ignition sources.

Keep containers securely sealed. Contents under pressure.

Store away from incompatible materials.

Store in a cool, dry, well ventilated area.

Avoid storage at temperatures higher than 40 deg C.

Store in an upright position.

Protect containers against physical damage.

Check regularly for spills and leaks.

Observe manufacturer's storing and handling recommendations.

_____________________________________________________

SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS

_____________________________________________________

+: Maybestoredtogether

O: Maybestoredtogetherwithspecificpreventions

X: Mustnotbestoredtogether

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

EXPOSURE CONTROLS

Source Material TWAppm TWAmg/m³ STELppm STELmg/m³

___________ ___________ _______ _______ _______ _______

AustraliaExposure DY-MARKLEADER 100 369 150 553

Standards STOCKMARKERLEADFREE

COLOURSAEROSOL

(Propyleneglycol

monomethylether)

AustraliaExposure ethanol(Ethylalcohol) 1000 1880

Standards

AustraliaExposure acetone(Acetone) 500 1185 1000 2375

Standards

AustraliaExposure propyleneglycol 100 369 150 553

Standards monomethylether-alpha

isomer(Propyleneglycol

monomethylether)

AustraliaExposure dibutylphthalate 5

Standards (Dibutylphthalate)

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 10 of 34

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

Source Material TWAppm TWAmg/m³ STELppm STELmg/m³

___________ ___________ _______ _______ _______ _______

AustraliaExposure dimethylether(Dimethyl 400 760 500 950

Standards ether)

EMERGENCY EXPOSURE LIMITS

Material RevisedIDLHValue(mg/m3) RevisedIDLHValue(ppm)

ethanol 3,300[LEL]

acetone 2,500[LEL]

dibutylphthalate 4,000

NOTES

ValuesmarkedLELindicatethattheIDLHwasbasedon10%ofthelowerexplosivelimit

forsafetyconsiderationseventhoughtherelevanttoxicologicaldataindicatedthat

irreversiblehealtheffectsorimpairmentofescapeexistedonlyathigherconcentrations.

MATERIAL DATA

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

PROPYLENEGLYCOLMONOMETHYLETHER-ALPHAISOMER:

■forpropyleneglycolmonomethylether(PGME)

OdourThreshold:10ppm.

TheTLV-TWAisprotectiveagainstdiscomfortcausedbyodour,againsteyeandskinirritation,andchronic

effects(includingpossibleliverandkidneydamage).

Individualsexposedto100ppmreportedatransientunpleasantodourwithslighteyeirritationafter

about1or2hours.At300ppm,mildirritationoftheeyesandnosedevelopedwithin5minutes;some

individualsfoundtheirritationhardlybearableafteraboutanhour.Aconcentrationof750ppmwashighly

irritating.Signsofcentralnervoussystemdepressiondevelopedat1000ppm.Neurological,clinicalchemical

andgeneralmedicalexaminationsshowednootherconspicuoustoxicity.

Concentrationsofthebeta-isomer,2-methoxy-1-propylacetatearelowincommercialgradesofPGMEand

teratogeniceffectsassociatedwiththisisomerareexpectedtobeabsent.

OdourSafetyFactor(OSF)

OSF=10(propyleneglycolmonomethylether).

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

ETHANOL:

■Forethanol:

OdourThresholdValue:49-716ppm(detection),101ppm(recognition)

Eyeandrespiratorytractirritationdonotappeartooccuratexposurelevelsoflessthan5000ppmand

theTLV-TWAisthoughttoprovideanadequatemarginofsafetyagainstsucheffects.Experimentsinmanshow

thatinhalationof1000ppmcausedslightsymptomsofpoisoningand5000ppmcausedstrongstuporandmorbid

sleepiness.Subjectsexposedto5000ppmto10000ppmexperiencedsmartingoftheeyesandnoseandcoughing.

Symptomsdisappearedwithinminutes.Inhalationalsocauseslocalirritatingeffectstotheeyesandupper

respiratorytract,headaches,sensationofheatintraoculartension,stupor,fatigueandaneedtosleep.At

15000ppmtherewascontinuouslachrymationandcoughing.

DIBUTYLPHTHALATE:

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

■Dibutylphosphatehascausedrespiratorytractirritationandheadacheinworkers.TheTLV-TWAis

thoughttobeprotectiveagainsttheseeffectsalthoughitispossiblethatthelimitisnotsufficientlylow

topreventsensoryeffects.

ACETONE:

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 11 of 34

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

■OdourThresholdValue:3.6ppm(detection),699ppm(recognition)

Saturationvapourconcentration:237000ppm@20C

NOTE:Detectortubesmeasuringinexcessof40ppm,areavailable.

ExposureatorbelowtherecommendedTLV-TWAisthoughttoprotecttheworkeragainstmildirritation

associatedwithbriefexposuresandthebioaccumulation,chronicirritationoftherespiratorytractand

headachesassociatedwithlong-termacetoneexposures.TheNIOSHREL-TWAissubstantiallylowerandhastaken

intoaccountslightirritationexperiencedbyvolunteersubjectsat300ppm.Mildirritationtoacclimatised

workersbeginsatabout750ppm-unacclimatisedsubjectswillexperienceirritationatabout350-500ppmbut

acclimatisationcanoccurrapidly.DisagreementbetweenthepeakbodiesisbasedlargelyontheviewbyACGIH

thatwidespreaduseofacetone,withoutevidenceofsignificantadversehealtheffectsathigher

concentrations,allowsacceptanceofahigherlimit.

Half-lifeofacetoneinbloodis3hourswhichmeansthatnoadjustmentforshift-lengthhastobemade

withreferencetothestandard8hour/day,40hoursperweekbecausebodyclearanceoccurswithinanyshift

withlowpotentialforaccumulation.

ASTELhasbeenestablishedtopreventexcursionsofacetonevapoursthatcouldcausedepressionofthe

centralnervoussystem.

OdourSafetyFactor(OSF)

OSF=38(ACETONE).

DIMETHYLETHER:

ETHANOL:

■Sensoryirritantsarechemicalsthatproducetemporaryandundesirableside-effectsontheeyes,noseor

throat.Historicallyoccupationalexposurestandardsfortheseirritantshavebeenbasedonobservationof

workers'responsestovariousairborneconcentrations.Presentdayexpectationsrequirethatnearlyevery

individualshouldbeprotectedagainstevenminorsensoryirritationandexposurestandardsareestablished

usinguncertaintyfactorsorsafetyfactorsof5to10ormore.Onoccasionanimalno-observable-effect-

levels(NOEL)areusedtodeterminetheselimitswherehumanresultsareunavailable.Anadditionalapproach,

typicallyusedbytheTLVcommittee(USA)indeterminingrespiratorystandardsforthisgroupofchemicals,

hasbeentoassignceilingvalues(TLVC)torapidlyactingirritantsandtoassignshort-termexposure

limits(TLVSTELs)whentheweightofevidencefromirritation,bioaccumulationandotherendpointscombine

towarrantsuchalimit.IncontrasttheMAKCommission(Germany)usesafive-categorysystembasedon

intensiveodour,localirritation,andeliminationhalf-life.Howeverthissystemisbeingreplacedtobe

consistentwiththeEuropeanUnion(EU)ScientificCommitteeforOccupationalExposureLimits(SCOEL);this

ismorecloselyalliedtothatoftheUSA.

OSHA(USA)concludedthatexposuretosensoryirritantscan:

causeinflammation

causeincreasedsusceptibilitytootherirritantsandinfectiousagents

leadtopermanentinjuryordysfunction

permitgreaterabsorptionofhazardoussubstancesand

acclimatetheworkertotheirritantwarningpropertiesofthesesubstancesthusincreasingtheriskof

overexposure.

ACETONE:

■Exposedindividualsarereasonablyexpectedtobewarned,bysmell,thattheExposureStandardisbeing

exceeded.

OdourSafetyFactor(OSF)isdeterminedtofallintoeitherClassAorB.

TheOdourSafetyFactor(OSF)isdefinedas:

OSF=ExposureStandard(TWA)ppm/OdourThresholdValue(OTV)ppm

Classificationintoclassesfollows:

Class OSF Description

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 12 of 34

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

Over90%ofexposedindividuals

areawarebysmellthatthe

ExposureStandard(TLV-TWAfor

example)isbeingreached,even

whendistractedbyworking

activities

26-550 As"A"for50-90%ofpersons

beingdistracted

1-26 As"A"forlessthan50%of

personsbeingdistracted

0.18-1 10-50%ofpersonsawareof

beingtestedperceivebysmell

thattheExposureStandardis

beingreached

<0.18 As"D"forlessthan10%of

personsawareofbeingtested

DIMETHYLETHER:

■fordimethylether:

Theno-effect-levelfordimethyletherissomewherebetween2000ppm(rabbits)and50,000ppm(humans)

withpossiblecardiacsensitisationoccurringaround200,000ppm(dogs).TheAIHAhasadoptedasafetyfactor

of100inrespecttothe50,000ppmlevelinitsrecommendationforaworkplaceenvironmentalexposurelevel

(WEEL)whichisthoughttoprotectagainstbothnarcoticandsensitisingeffects.Thislevelisconsistent

withtheTLV-TWAof400ppmfordiethyletherandshouldbeeasilyachievableusingcurrenttechnologies.The

useofthetraditionallyallowableexcursionof1.25tothelevelof6.25ppmisfelttobemorethan

adequateasanuppersafelimitofexposure.

Humandata:

50,000ppm(12mins):Feelingsofmildintoxication.

75,000ppm(12mins):Asaboveplusslightlackofattenuation.

82,000ppm(12mins):Someincoordination,slightblurringofvision

(30mins):Asaboveplusanalgesiaofthefaceandrushingofbloodtotheface.

100,000ppm(10-20mins):Narcoticsymptoms;(64mins):Sickness(assumedtobenausea)

144,000ppm(36mins):Unconsciousness.

Mayactasasimpleasphyxiants;thesearegaseswhich,whenpresentinhighconcentrations,reducethe

oxygencontentinairbelowthatrequiredtosupportbreathing,consciousnessandlife;lossofconsciousness,

withdeathbysuffocationmayrapidlyoccurinanoxygendeficientatmosphere.

CARE:Mostsimpleasphyxiantsareodourlessorpossesslowodourandthereisnowarningonentryintoan

oxygendeficientatmosphere.Ifthereisanydoubt,oxygencontentcanbecheckedsimplyandquickly.Itmay

notbeappropriatetoonlyrecommendanexposurestandardforsimpleasphyxiantsratheritisessentialthat

sufficientoxygenbemaintained.Airnormallyhas21percentoxygenbyvolume,with18percentregardedas

minimumundernormalatmosphericpressuretomaintainconsciousness/life.Atpressuressignificantlyhigher

orlowerthannormalatmosphericpressure,expertguidanceshouldbesought.

PERSONAL PROTECTION

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 13 of 34

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

EYE

Safetyglasseswithsideshields.

Chemicalgoggles.

Contactlensesmayposeaspecialhazard;softcontactlensesmayabsorbandconcentrateirritants.A

writtenpolicydocument,describingthewearingoflensorrestrictionsonuse,shouldbecreatedforeach

workplaceortask.Thisshouldincludeareviewoflensabsorptionandadsorptionfortheclassof

chemicalsinuseandanaccountofinjuryexperience.Medicalandfirst-aidpersonnelshouldbetrainedin

theirremovalandsuitableequipmentshouldbereadilyavailable.Intheeventofchemicalexposure,begin

eyeirrigationimmediatelyandremovecontactlensassoonaspracticable.Lensshouldberemovedatthe

firstsignsofeyerednessorirritation-lensshouldberemovedinacleanenvironmentonlyafterworkers

havewashedhandsthoroughly.[CDCNIOSHCurrentIntelligenceBulletin59].

HANDS/FEET

Neoprenegloves.

Nospecialequipmentneededwhenhandlingsmallquantities.

OTHERWISE:

Forpotentiallymoderateexposures:

Weargeneralprotectivegloves,eg.lightweightrubbergloves.

Forpotentiallyheavyexposures:

Wearchemicalprotectivegloves,eg.PVC.andsafetyfootwear.

OTHER

■Nospecialequipmentneededwhenhandlingsmallquantities.

OTHERWISE:

Overalls.

Skincleansingcream.

Eyewashunit.

Donotsprayonhotsurfaces.

Theclothingwornbyprocessoperatorsinsulatedfromearthmaydevelopstaticchargesfarhigher(upto

100times)thantheminimumignitionenergiesforvariousflammablegas-airmixtures.Thisholdstruefora

widerangeofclothingmaterialsincludingcotton.

Avoiddangerouslevelsofchargebyensuringalowresistivityofthesurfacematerialwornoutermost.

BRETHERICK:HandbookofReactiveChemicalHazards.

RESPIRATOR

Positivepressure,fullface,air-suppliedbreathingapparatusshouldbeusedforworkinenclosedspaces

ifaleakissuspectedortheprimarycontainmentistobeopened(e.g.foracylinderchange)

Air-suppliedbreathingapparatusisrequiredwherereleaseofgasfromprimarycontainmentiseither

suspectedordemonstrated.

Thelocalconcentrationofmaterial,quantityandconditionsofusedeterminethetypeofpersonalprotective

equipmentrequired.ForfurtherinformationconsultsitespecificCHEMWATCHdata(ifavailable),oryour

OccupationalHealthandSafetyAdvisor.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 14 of 34

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION

ENGINEERING CONTROLS

■Generalexhaustisadequateundernormalconditions.Ifriskofoverexposureexists,wearSAAapproved

respirator.Correctfitisessentialtoobtainadequateprotection.

Provideadequateventilationinwarehouseorclosedstorageareas.

Aircontaminantsgeneratedintheworkplacepossessvarying"escape"velocitieswhich,inturn,determinethe

"capturevelocities"offreshcirculatingairrequiredtoeffectivelyremovethecontaminant.

TypeofContaminant: Speed:

aerosols,(releasedatlowvelocityintozone 0.5-1m/s

ofactivegeneration)

directspray,spraypaintinginshallowbooths, 1-2.5m/s(200-500f/min.)

gasdischarge(activegenerationintozoneof

rapidairmotion)

Withineachrangetheappropriatevaluedependson:

Lowerendoftherange Upperendoftherange

1:Roomaircurrentsminimalorfavourableto 1:Disturbingroomaircurrents

capture

2:Contaminantsoflowtoxicityorofnuisance 2:Contaminantsofhightoxicity

valueonly.

3:Intermittent,lowproduction. 3:Highproduction,heavyuse

4:Largehoodorlargeairmassinmotion 4:Smallhood-localcontrolonly

Simpletheoryshowsthatairvelocityfallsrapidlywithdistanceawayfromtheopeningofasimple

extractionpipe.Velocitygenerallydecreaseswiththesquareofdistancefromtheextractionpoint(in

simplecases).Thereforetheairspeedattheextractionpointshouldbeadjusted,accordingly,after

referencetodistancefromthecontaminatingsource.Theairvelocityattheextractionfan,forexample,

shouldbeaminimumof1-2m/s(200-400f/min.)forextractionofsolventsgeneratedinatank2meters

distantfromtheextractionpoint.Othermechanicalconsiderations,producingperformancedeficitswithinthe

extractionapparatus,makeitessentialthattheoreticalairvelocitiesaremultipliedbyfactorsof10or

morewhenextractionsystemsareinstalledorused.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

APPEARANCE

■Notethatallofthemonopropyleneglycolethersmayexistintwoisomericforms,alphaorbeta.Thealpha

form,whichisthermodynamicallyfavoredduringsynthesis,consistsofasecondaryalcoholconfiguration.The

betaformconsistsofaprimaryalcohol.Thetwoisomericformsareshownabove.Thedi-andtripropylene

glycolethersmayformupto4and8isomericforms,respectively.Evenso,allisomersexhibiteitherthe

"alpha"or"beta"configuration,existingassecondaryorprimaryalcohols,respectively.Thedistributionof

isomericformsforthedi-andtripropyleneglycols,aswiththemono-PGEs,alsoresultsinpredominantlythe

alphaform(i.e.,asecondaryalcohol).Itshouldbenotedthatonlythealphaisomerandisomericmixtures

(consistingpredominantlyofthealphaisomer)areproducedcommercially;thepurifiedbetaisomerisnot

producedatthistime.

Suppliedasanaerosolpack.ContentsunderPRESSURE.Containshighlyflammablehydrocarbonpropellant.

Colouredflammableliquid;doesnotmixwithwater.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 15 of 34

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL PROPERTIES

Liquid.

Gas.

Does not mix with water.

State Liquid MolecularWeight NotApplicable

MeltingRange(°C) NotAvailable Viscosity NotAvailable

BoilingRange(°C) NotAvailable Solubilityinwater(g/L) Immiscible

FlashPoint(°C) NotAvailable pH(1%solution) NotApplicable

DecompositionTemp(°C) NotAvailable pH(assupplied) NotApplicable

AutoignitionTemp(°C) NotAvailable VapourPressure(kPa) NotAvailable

UpperExplosiveLimit(%) NotAvailable SpecificGravity(water=1) NotAvailable

LowerExplosiveLimit(%) NotAvailable RelativeVapourDensity NotAvailable

(air=1)

VolatileComponent(%vol) NotAvailable EvaporationRate NotAvailable

ethanol

■logKow(Sangster1997): -0.3

acetone

■logKow(Prager1995): -0.24

■logKow(Sangster1997): -0.24

dibutylphthalate

■logKow(Sangster1997): 4.72

dimethylether

logKow(Sangster1997):0.1

Section 10 - CHEMICAL STABILITY

CONDITIONS CONTRIBUTING TO INSTABILITY

Elevated temperatures.

Presence of open flame.

Product is considered stable.

Hazardous polymerisation will not occur.

For incompatible materials - refer to Section 7 - Handling and Storage.

Section 11 - TOXICOLOGICAL INFORMATION

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

■Accidentalingestionofthematerialmaybedamagingtothehealthoftheindividual.

Notnormallyahazardduetophysicalformofproduct.

Consideredanunlikelyrouteofentryincommercial/industrialenvironments.

EYE

■Notconsideredtobeariskbecauseoftheextremevolatilityofthegas.

Eyecontactwithalkylethers(vapourorliquid)mayproduceirritation,rednessandtears.

Thereisevidencethatmaterialmayproduceeyeirritationinsomepersonsandproduceeyedamage24hoursor

moreafterinstillation.Severeinflammationmaybeexpectedwithpain.Theremaybedamagetothecornea.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 16 of 34

Section 11 - TOXICOLOGICAL INFORMATION

Unlesstreatmentispromptandadequatetheremaybepermanentlossofvision.Conjunctivitiscanoccur

followingrepeatedexposure.

Directcontactoftheeyewithethanol(alcohol)maycauseanimmediatestingingandburningsensation,with

reflexclosureofthelid,andatemporary,tearinginjurytothecorneatogetherwithrednessofthe

conjunctiva.Discomfortmaylast2daysbutusuallytheinjuryhealswithouttreatment.

Theliquidmayproduceeyediscomfortandiscapableofcausingtemporaryimpairmentofvisionand/or

transienteyeinflammation,ulceration.

SKIN

■Repeatedexposuremaycauseskincracking,flakingordryingfollowingnormalhandlinganduse.

Skincontactwiththematerialmaydamagethehealthoftheindividual;systemiceffectsmayresultfollowing

absorption.

Thereissomeevidencetosuggestthatthematerialmaycausemoderateinflammationoftheskineither

followingdirectcontactorafteradelayofsometime.Repeatedexposurecancausecontactdermatitiswhich

ischaracterisedbyredness,swellingandblistering.

Spraymistmayproducediscomfort.

Alkylethersmaydefatanddehydratetheskinproducingdermatoses.Absorptionmayproduceheadache,

dizziness,andcentralnervoussystemdepression.

Opencuts,abradedorirritatedskinshouldnotbeexposedtothismaterial.

Entryintotheblood-stream,through,forexample,cuts,abrasionsorlesions,mayproducesystemicinjury

withharmfuleffects.Examinetheskinpriortotheuseofthematerialandensurethatanyexternaldamage

issuitablyprotected.

INHALED

■Inhalationofvapoursmaycausedrowsinessanddizziness.Thismaybeaccompaniedbysleepiness,reduced

alertness,lossofreflexes,lackofco-ordination,andvertigo.

Inhalationofaerosols(mists,fumes),generatedbythematerialduringthecourseofnormalhandling,maybe

damagingtothehealthoftheindividual.

Thereissomeevidencetosuggestthatthematerialcancauserespiratoryirritationinsomepersons.The

body'sresponsetosuchirritationcancausefurtherlungdamage.

Inhalationoftoxicgasesmaycause:

CentralNervousSystemeffectsincludingdepression,headache,confusion,dizziness,stupor,comaand

seizures;

respiratory:acutelungswellings,shortnessofbreath,wheezing,rapidbreathing,othersymptomsand

respiratoryarrest;

heart:collapse,irregularheartbeatsandcardiacarrest;

gastrointestinal:irritation,ulcers,nauseaandvomiting(maybebloody),andabdominalpain.

Followinginhalation,etherscauselethargyandstupor.Inhalingloweralkylethersresultsinheadache,

dizziness,weakness,blurredvision,seizuresandpossiblecoma.Lowbloodpressure,slowheartbeatand

cardiovascularcollapsemaybeseenwiththroatirritation,irregularbreathing,pulmonaryoedemaand

respiratoryarrest.Nausea,vomitingandsalivationmaybeseen.Therehavebeendeathsreported,and

convulsionsandparalysiscanbefoundinseverecases.Massiveexposurescancausedamagetothekidneyand

liver.

Materialishighlyvolatileandmayquicklyformaconcentratedatmosphereinconfinedorunventilatedareas.

Vapourisheavierthanairandmaydisplaceandreplaceairinbreathingzone,actingasasimpleasphyxiant.

Thismayhappenwithlittlewarningofoverexposure.

Inhalationofhighconcentrationsofgas/vapourcauseslungirritationwithcoughingandnausea,central

nervousdepressionwithheadacheanddizziness,slowingofreflexes,fatigueandinco-ordination.

WARNING:Intentionalmisusebyconcentrating/inhalingcontentsmaybelethal.

CHRONIC HEALTH EFFECTS

■Ampleevidenceexists,fromresultsinexperimentation,thatdevelopmentaldisordersaredirectlycausedby

humanexposuretothematerial.

Prolongedorrepeatedskincontactmaycausedryingwithcracking,irritationandpossibledermatitis

following.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

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Section 11 - TOXICOLOGICAL INFORMATION

Substanceaccumulation,inthehumanbody,mayoccurandmaycausesomeconcernfollowingrepeatedorlong-

termoccupationalexposure.

Principalrouteofoccupationalexposuretothegasisbyinhalation.

Chronicexposuretoalkylethersmayresultinlossofappetite,excessivethirst,fatigue,andweightloss.

Workersexposedtoacetoneforlongperiodsshowedinflammationoftheairways,stomachandsmallbowel,

attacksofgiddinessandlossofstrength.Exposuretoacetonemayenhancethelivertoxicityofchlorinated

solvents.

TOXICITY AND IRRITATION

■unlessotherwisespecifieddataextractedfromRTECS-RegisterofToxicEffectsofChemicalSubstances.

■forpropyleneglycolethers(PGEs):

Typicalpropyleneglycolethersincludepropyleneglycoln-butylether(PnB);dipropyleneglycoln-butyl

ether(DPnB);dipropyleneglycolmethyletheracetate(DPMA);tripropyleneglycolmethylether(TPM).

TestingofawidevarietyofpropyleneglycolethersTestingofawidevarietyofpropyleneglycolethershas

shownthatpropyleneglycol-basedethersarelesstoxicthansomeethersoftheethyleneseries.Thecommon

toxicitiesassociatedwiththelowermolecularweighthomologuesoftheethyleneseries,suchasadverse

effectsonreproductiveorgans,thedevelopingembryoandfetus,blood(haemolyticeffects),orthymus,are

notseenwiththecommercial-gradepropyleneglycolethers.Intheethyleneseries,metabolismofthe

terminalhydroxylgroupproducesanalkoxyaceticacid.Thereproductiveanddevelopmentaltoxicitiesofthe

lowermolecularweighthomologuesintheethyleneseriesareduespecificallytotheformationof

methoxyaceticandethoxyaceticacids.

Longerchainlengthhomologuesintheethyleneseriesarenotassociatedwiththereproductivetoxicitybut

cancausehaemolysisinsensitivespecies,alsothroughformationofanalkoxyaceticacid.Thepredominant

alphaisomerofallthePGEs(thermodynamicallyfavoredduringmanufactureofPGEs)isasecondaryalcohol

incapableofforminganalkoxypropionicacid.Incontrastbeta-isomersareabletoformthealkoxypropionic

acidsandthesearelinkedtoteratogeniceffects(andpossiblyhaemolyticeffects).

Thisalphaisomercomprisesgreaterthan95%oftheisomericmixtureinthecommercialproduct.

Becausethealphaisomercannotformanalkoxypropionicacid,thisisthemostlikelyreasonforthelackof

toxicityshownbythePGEsasdistinctfromthelowermolecularweightethyleneglycolethers.More

importantly,however,veryextensiveempiricaltestdatashowthatthisclassofcommercial-gradeglycol

etherpresentsalowtoxicityhazard.PGEs,whethermono,di-ortripropyleneglycol-based(andnomatter

whatthealcoholgroup),showaverysimilarpatternoflowtonon-detectabletoxicityofanytypeatdoses

orexposurelevelsgreatlyexceedingthoseshowingpronouncedeffectsfromtheethyleneseries.Oneofthe

primarymetabolitesofthepropyleneglycolethersispropyleneglycol,whichisoflowtoxicityand

completelymetabolisedinthebody.

Asaclass,thepropyleneglycolethersarerapidlyabsorbedanddistributedthroughoutthebodywhen

introducedbyinhalationororalexposure.Dermalabsorptionissomewhatslowerbutsubsequentdistribution

israpid.MostexcretionforPGEsisviatheurineandexpiredair.Asmallportionisexcretedinthefaeces.

AsagroupPGEsexhibitslowacutetoxicitybytheoral,dermal,andinhalationroutes.RatoralLD50srange

from>3,000mg/kg(PnB)to>5,000mg/kg(DPMA).DermalLD50sareall>2,000mg/kg(PnB,&DPnB;whereno

deathsoccurred),andrangingupto>15,000mg/kg(TPM).InhalationLC50valueswerehigherthan5,000mg/m3

forDPMA(4-hourexposure),andTPM(1-hourexposure).ForDPnBthe4-hourLC50is>2,040mg/m3.ForPnB,the

4-hourLC50was>651ppm(>3,412mg/m3),representingthehighestpracticallyattainablevaporlevel.No

deathsoccurredattheseconcentrations.PnBandTPMaremoderatelyirritatingtoeyeswhiletheremaining

categorymembersareonlyslightlyirritatingtononirritating.PnBismoderatelyirritatingtoskinwhile

theremainingcategorymembersareslightlytonon-irritating

Noneareskinsensitisers.

Inrepeateddosestudiesrangingindurationfrom2to13weeks,fewadverseeffectswerefoundevenathigh

exposurelevelsandeffectsthatdidoccurweremildinnature.Bytheoralrouteofadministration,NOAELs

of350mg/kg-d(PnB–13wk)and450mg/kg-d(DPnB–13wk)wereobservedforliverandkidneyweight

increases(withoutaccompanyinghistopathology).LOAELsforthesetwochemicalswere1000mg/kg-d(highest

dosetested).

Dermalrepeated-dosetoxicitytestshavebeenperformedformanyPGEs.ForPnB,noeffectswereseenina13-

wkstudyatdosesashighas1,000mg/kg-d.Adoseof273mg/kg-dconstitutedaLOAEL(increasedorgan

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 18 of 34

Section 11 - TOXICOLOGICAL INFORMATION

weightswithouthistopathology)ina13-weekdermalstudyforDPnB.ForTPM,increasedkidneyweights(no

histopathology)andtransientlydecreasedbodyweightswerefoundatadoseof2,895mg/kg-dina90-day

studyinrabbits.Byinhalation,noeffectswereobservedin2-weekstudiesinratsatthehighesttested

concentrationsof3244mg/m3(600ppm)forPnBand2,010mg/m3(260ppm)forDPnB.TPMcausedincreasedliver

weightswithouthistopathologybyinhalationina2-weekstudyataLOAELof360mg/m3(43ppm).Inthis

study,thehighesttestedTPMconcentration,1010mg/m3(120ppm),alsocausedincreasedliverweights

withoutaccompanyinghistopathology.Althoughnorepeated-dosestudiesareavailablefortheoralroutefor

TPM,orforanyrouteforDPMA,itisanticipatedthatthesechemicalswouldbehavesimilarlytoother

categorymembers.

Oneandtwo-generationreproductivetoxicitytestinghasbeenconductedinmice,rats,andrabbitsviathe

oralorinhalationroutesofexposureonPMandPMA.InaninhalationratstudyusingPM,theNOAELfor

parentaltoxicityis300ppm(1106mg/m3)withdecreasesinbodyandorganweightsoccurringattheLOAELof

1000ppm(3686mg/m3).ForoffspringtoxicitytheNOAELis1000ppm(3686mg/m3),withdecreasedbodyweights

occurringat3000ppm(11058mg/m3).ForPMA,theNOAELforparentalandoffspringtoxicityis1000mg/kg/d.

inatwogenerationgavagestudyinrats.Noadverseeffectswerefoundonreproductiveorgans,fertility

rates,orotherindicescommonlymonitoredinsuchstudies.Inaddition,thereisnoevidencefrom

histopathologicaldatafromrepeated-dosestudiesforthecategorymembersthatwouldindicatethatthese

chemicalswouldposeareproductivehazardtohumanhealth.

IndevelopmentaltoxicitystudiesmanyPGEshavebeentestedbyvariousroutesofexposureandinvarious

speciesatsignificantexposurelevelsandshownofrankdevelopmentaleffects.Duetotherapidhydrolysis

ofDPMAtoDPM,DPMAwouldnotbeexpectedtoshowteratogeniceffects.Athighdoseswherematernaltoxicity

occurs(e.g.,significantbodyweightloss),anincreasedincidenceofsomeanomaliessuchasdelayed

skeletalossificationorincreased13thribs,havebeenreported.CommerciallyavailablePGEsshowedno

teratogenicity.

Theweightoftheevidenceindicatesthatpropyleneglycolethersarenotlikelytobegenotoxic.Invitro,

negativeresultshavebeenseeninanumberofassaysforPnB,DPnB,DPMAandTPM.Positiveresultswereonly

seenin3outof5chromosomeaberrationassaysinmammaliancellswithDPnB.However,negativeresultswere

seeninamousemicronucleusassaywithDPnBandPM.Thus,thereisnoevidencetosuggestthesePGEswould

begenotoxicinvivo.Ina2-yearbioassayonPM,therewerenostatisticallysignificantincreasesintumors

inratsandmice.

Thematerialmaycauseskinirritationafterprolongedorrepeatedexposureandmayproduceoncontactskin

redness,swelling,theproductionofvesicles,scalingandthickeningoftheskin.

foracetone:

Theacutetoxicityofacetoneislow.Acetoneisnotaskinirritantorsensitiserbutisadefattingagent

totheskin.Acetoneisaneyeirritant.Thesubchronictoxicityofacetonehasbeenexaminedinmiceand

ratsthatwereadministeredacetoneinthedrinkingwaterandagaininratstreatedbyoralgavage.Acetone-

inducedincreasesinrelativekidneyweightchangeswereobservedinmaleandfemaleratsusedintheoral13-

weekstudy.Acetonetreatmentcausedincreasesintherelativeliverweightinmaleandfemaleratsthatwere

notassociatedwithhistopathologiceffectsandtheeffectsmayhavebeenassociatedwithmicrosomalenzyme

induction.Haematologiceffectsconsistentwithmacrocyticanaemiawerealsonotedinmaleratsalongwith

hyperpigmentationinthespleen.Themostnotablefindingsinthemicewereincreasedliveranddecreased

spleenweights.Overall,theno-observed-effect-levelsinthedrinkingwaterstudywere1%formalerats(900

mg/kg/d)andmalemice(2258mg/kg/d),2%forfemalemice(5945mg/kg/d),and5%forfemalerats(3100

mg/kg/d).Fordevelopmentaleffects,astatisticallysignificantreductioninfoetalweight,andaslight,

butstatisticallysignificantincreaseinthepercentincidenceoflaterresorptionswereseeninmiceat15,

665mg/m3andinratsat26,100mg/m3.Theno-observable-effectlevelfordevelopmentaltoxicitywas

determinedtobe5220mg/m3forbothratsandmice.

Teratogeniceffectswerenotobservedinratsandmicetestedat26,110and15,665mg/m3,respectively.

Lifetimedermalcarcinogenicitystudiesinmicetreatedwithupto0.2mLofacetonedidnotrevealany

increaseinorgantumorincidencerelativetountreatedcontrolanimals.

Thescientificliteraturecontainsmanydifferentstudiesthathavemeasuredeithertheneurobehavioural

performanceorneurophysiologicalresponseofhumansexposedtoacetone.Effectlevelsrangingfromabout600

togreaterthan2375mg/m3havebeenreported.Neurobehavioralstudieswithacetone-exposedemployeeshave

recentlyshownthat8-hrexposuresinexcessof2375mg/m3werenotassociatedwithanydose-relatedchanges

inresponsetime,vigilance,ordigitspanscores.Clinicalcasestudies,controlledhumanvolunteerstudies,

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Section 11 - TOXICOLOGICAL INFORMATION

animalresearch,andoccupationalfieldevaluationsallindicatethattheNOAELforthiseffectis2375mg/m3

orgreater.

ETHANOL:

TOXICITY IRRITATION

Oral(rat)LD50:7060mg/kg Skin(rabbit):20mg/24hr-Moderate

Oral(human)LDLo:1400mg/kg Skin(rabbit):400mg(open)-Mild

Oral(man)TDLo:50mg/kg Eye(rabbit):100mg/24hr-Moderate

Oral(man)TDLo:1.40mg/kg Eye(rabbit):500mgSEVERE

Oral(woman)TDLo:256mg/kg/12wks

Inhalation(rat)LC50:20,000ppm/10h

Inhalation(rat)LC50:64000ppm/4h

■Thematerialmaycauseskinirritationafterprolongedorrepeatedexposureandmayproduceoncontactskin

redness,swelling,theproductionofvesicles,scalingandthickeningoftheskin.

ACETONE:

TOXICITY IRRITATION

Oral(man)TDLo:2857mg/kg Eye(human):500ppm-Irritant

Oral(rat)LD50:5800mg/kg Eye(rabbit):3.95mg-SEVERE

Inhalation(human)TCLo:500ppm Eye(rabbit):20mg/24hr-Moderate

Inhalation(man)TCLo:12000ppm/4hr Skin(rabbit):395mg(open)-Mild

Inhalation(man)TCLo:10mg/m³/6hr Skin(rabbit):500mg/24hr-Mild

Inhalation(rat)LC50:50100mg/m³/8hr

Dermal(rabbit)LD50:20000mg/kg

■Thematerialmaycauseskinirritationafterprolongedorrepeatedexposureandmayproduceoncontactskin

redness,swelling,theproductionofvesicles,scalingandthickeningoftheskin.

foracetone:

Theacutetoxicityofacetoneislow.Acetoneisnotaskinirritantorsensitiserbutisadefattingagent

totheskin.Acetoneisaneyeirritant.Thesubchronictoxicityofacetonehasbeenexaminedinmiceand

ratsthatwereadministeredacetoneinthedrinkingwaterandagaininratstreatedbyoralgavage.Acetone-

inducedincreasesinrelativekidneyweightchangeswereobservedinmaleandfemaleratsusedintheoral13-

weekstudy.Acetonetreatmentcausedincreasesintherelativeliverweightinmaleandfemaleratsthatwere

notassociatedwithhistopathologiceffectsandtheeffectsmayhavebeenassociatedwithmicrosomalenzyme

induction.Haematologiceffectsconsistentwithmacrocyticanaemiawerealsonotedinmaleratsalongwith

hyperpigmentationinthespleen.Themostnotablefindingsinthemicewereincreasedliveranddecreased

spleenweights.Overall,theno-observed-effect-levelsinthedrinkingwaterstudywere1%formalerats(900

mg/kg/d)andmalemice(2258mg/kg/d),2%forfemalemice(5945mg/kg/d),and5%forfemalerats(3100

mg/kg/d).Fordevelopmentaleffects,astatisticallysignificantreductioninfoetalweight,andaslight,

butstatisticallysignificantincreaseinthepercentincidenceoflaterresorptionswereseeninmiceat15,

665mg/m3andinratsat26,100mg/m3.Theno-observable-effectlevelfordevelopmentaltoxicitywas

determinedtobe5220mg/m3forbothratsandmice.

Teratogeniceffectswerenotobservedinratsandmicetestedat26,110and15,665mg/m3,respectively.

Lifetimedermalcarcinogenicitystudiesinmicetreatedwithupto0.2mLofacetonedidnotrevealany

increaseinorgantumorincidencerelativetountreatedcontrolanimals.

Thescientificliteraturecontainsmanydifferentstudiesthathavemeasuredeithertheneurobehavioural

performanceorneurophysiologicalresponseofhumansexposedtoacetone.Effectlevelsrangingfromabout600

togreaterthan2375mg/m3havebeenreported.Neurobehavioralstudieswithacetone-exposedemployeeshave

recentlyshownthat8-hrexposuresinexcessof2375mg/m3werenotassociatedwithanydose-relatedchanges

inresponsetime,vigilance,ordigitspanscores.Clinicalcasestudies,controlledhumanvolunteerstudies,

animalresearch,andoccupationalfieldevaluationsallindicatethattheNOAELforthiseffectis2375mg/m3

orgreater.

PROPYLENEGLYCOLMONOMETHYLETHER-ALPHAISOMER:

TOXICITY IRRITATION

continued...

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Section 11 - TOXICOLOGICAL INFORMATION

Oral(rat)LD50:3739mg/kg Skin(rabbit)500mgOpen-Mild

Inhalation(human)TCLo:3000ppm Eye(rabbit)230mgMild

Inhalation(rat)LC50:10000ppm/5h. Eye(rabbit)500mg/24h.-Mild

Dermal(rabbit)LD50:13000mg/kg Eye(rabbit):100mgSEVERE

■forpropyleneglycolethers(PGEs):

Typicalpropyleneglycolethersincludepropyleneglycoln-butylether(PnB);dipropyleneglycoln-butyl

ether(DPnB);dipropyleneglycolmethyletheracetate(DPMA);tripropyleneglycolmethylether(TPM).

TestingofawidevarietyofpropyleneglycolethersTestingofawidevarietyofpropyleneglycolethershas

shownthatpropyleneglycol-basedethersarelesstoxicthansomeethersoftheethyleneseries.Thecommon

toxicitiesassociatedwiththelowermolecularweighthomologuesoftheethyleneseries,suchasadverse

effectsonreproductiveorgans,thedevelopingembryoandfetus,blood(haemolyticeffects),orthymus,are

notseenwiththecommercial-gradepropyleneglycolethers.Intheethyleneseries,metabolismofthe

terminalhydroxylgroupproducesanalkoxyaceticacid.Thereproductiveanddevelopmentaltoxicitiesofthe

lowermolecularweighthomologuesintheethyleneseriesareduespecificallytotheformationof

methoxyaceticandethoxyaceticacids.

Longerchainlengthhomologuesintheethyleneseriesarenotassociatedwiththereproductivetoxicitybut

cancausehaemolysisinsensitivespecies,alsothroughformationofanalkoxyaceticacid.Thepredominant

alphaisomerofallthePGEs(thermodynamicallyfavoredduringmanufactureofPGEs)isasecondaryalcohol

incapableofforminganalkoxypropionicacid.Incontrastbeta-isomersareabletoformthealkoxypropionic

acidsandthesearelinkedtoteratogeniceffects(andpossiblyhaemolyticeffects).

Thisalphaisomercomprisesgreaterthan95%oftheisomericmixtureinthecommercialproduct.

Becausethealphaisomercannotformanalkoxypropionicacid,thisisthemostlikelyreasonforthelackof

toxicityshownbythePGEsasdistinctfromthelowermolecularweightethyleneglycolethers.More

importantly,however,veryextensiveempiricaltestdatashowthatthisclassofcommercial-gradeglycol

etherpresentsalowtoxicityhazard.PGEs,whethermono,di-ortripropyleneglycol-based(andnomatter

whatthealcoholgroup),showaverysimilarpatternoflowtonon-detectabletoxicityofanytypeatdoses

orexposurelevelsgreatlyexceedingthoseshowingpronouncedeffectsfromtheethyleneseries.Oneofthe

primarymetabolitesofthepropyleneglycolethersispropyleneglycol,whichisoflowtoxicityand

completelymetabolisedinthebody.

Asaclass,thepropyleneglycolethersarerapidlyabsorbedanddistributedthroughoutthebodywhen

introducedbyinhalationororalexposure.Dermalabsorptionissomewhatslowerbutsubsequentdistribution

israpid.MostexcretionforPGEsisviatheurineandexpiredair.Asmallportionisexcretedinthefaeces.

AsagroupPGEsexhibitslowacutetoxicitybytheoral,dermal,andinhalationroutes.RatoralLD50srange

from>3,000mg/kg(PnB)to>5,000mg/kg(DPMA).DermalLD50sareall>2,000mg/kg(PnB,&DPnB;whereno

deathsoccurred),andrangingupto>15,000mg/kg(TPM).InhalationLC50valueswerehigherthan5,000mg/m3

forDPMA(4-hourexposure),andTPM(1-hourexposure).ForDPnBthe4-hourLC50is>2,040mg/m3.ForPnB,the

4-hourLC50was>651ppm(>3,412mg/m3),representingthehighestpracticallyattainablevaporlevel.No

deathsoccurredattheseconcentrations.PnBandTPMaremoderatelyirritatingtoeyeswhiletheremaining

categorymembersareonlyslightlyirritatingtononirritating.PnBismoderatelyirritatingtoskinwhile

theremainingcategorymembersareslightlytonon-irritating

Noneareskinsensitisers.

Inrepeateddosestudiesrangingindurationfrom2to13weeks,fewadverseeffectswerefoundevenathigh

exposurelevelsandeffectsthatdidoccurweremildinnature.Bytheoralrouteofadministration,NOAELs

of350mg/kg-d(PnB–13wk)and450mg/kg-d(DPnB–13wk)wereobservedforliverandkidneyweight

increases(withoutaccompanyinghistopathology).LOAELsforthesetwochemicalswere1000mg/kg-d(highest

dosetested).

Dermalrepeated-dosetoxicitytestshavebeenperformedformanyPGEs.ForPnB,noeffectswereseenina13-

wkstudyatdosesashighas1,000mg/kg-d.Adoseof273mg/kg-dconstitutedaLOAEL(increasedorgan

weightswithouthistopathology)ina13-weekdermalstudyforDPnB.ForTPM,increasedkidneyweights(no

histopathology)andtransientlydecreasedbodyweightswerefoundatadoseof2,895mg/kg-dina90-day

studyinrabbits.Byinhalation,noeffectswereobservedin2-weekstudiesinratsatthehighesttested

concentrationsof3244mg/m3(600ppm)forPnBand2,010mg/m3(260ppm)forDPnB.TPMcausedincreasedliver

weightswithouthistopathologybyinhalationina2-weekstudyataLOAELof360mg/m3(43ppm).Inthis

study,thehighesttestedTPMconcentration,1010mg/m3(120ppm),alsocausedincreasedliverweights

withoutaccompanyinghistopathology.Althoughnorepeated-dosestudiesareavailablefortheoralroutefor

continued...

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Section 11 - TOXICOLOGICAL INFORMATION

TPM,orforanyrouteforDPMA,itisanticipatedthatthesechemicalswouldbehavesimilarlytoother

categorymembers.

Oneandtwo-generationreproductivetoxicitytestinghasbeenconductedinmice,rats,andrabbitsviathe

oralorinhalationroutesofexposureonPMandPMA.InaninhalationratstudyusingPM,theNOAELfor

parentaltoxicityis300ppm(1106mg/m3)withdecreasesinbodyandorganweightsoccurringattheLOAELof

1000ppm(3686mg/m3).ForoffspringtoxicitytheNOAELis1000ppm(3686mg/m3),withdecreasedbodyweights

occurringat3000ppm(11058mg/m3).ForPMA,theNOAELforparentalandoffspringtoxicityis1000mg/kg/d.

inatwogenerationgavagestudyinrats.Noadverseeffectswerefoundonreproductiveorgans,fertility

rates,orotherindicescommonlymonitoredinsuchstudies.Inaddition,thereisnoevidencefrom

histopathologicaldatafromrepeated-dosestudiesforthecategorymembersthatwouldindicatethatthese

chemicalswouldposeareproductivehazardtohumanhealth.

IndevelopmentaltoxicitystudiesmanyPGEshavebeentestedbyvariousroutesofexposureandinvarious

speciesatsignificantexposurelevelsandshownofrankdevelopmentaleffects.Duetotherapidhydrolysis

ofDPMAtoDPM,DPMAwouldnotbeexpectedtoshowteratogeniceffects.Athighdoseswherematernaltoxicity

occurs(e.g.,significantbodyweightloss),anincreasedincidenceofsomeanomaliessuchasdelayed

skeletalossificationorincreased13thribs,havebeenreported.CommerciallyavailablePGEsshowedno

teratogenicity.

Theweightoftheevidenceindicatesthatpropyleneglycolethersarenotlikelytobegenotoxic.Invitro,

negativeresultshavebeenseeninanumberofassaysforPnB,DPnB,DPMAandTPM.Positiveresultswereonly

seenin3outof5chromosomeaberrationassaysinmammaliancellswithDPnB.However,negativeresultswere

seeninamousemicronucleusassaywithDPnBandPM.Thus,thereisnoevidencetosuggestthesePGEswould

begenotoxicinvivo.Ina2-yearbioassayonPM,therewerenostatisticallysignificantincreasesintumors

inratsandmice.

NOTE: ForPGE-mixedisomers:Exposureofpregnantratsandrabbitstothesubstancedidnotgiveriseto

teratogeniceffectsatconcentrationsupto3000ppm.Foetotoxiceffectswereseeninratsbutnotinrabbits

atthis concentration;maternaltoxicitywasnotedinbothspecies.

DIBUTYLPHTHALATE:

TOXICITY IRRITATION

Oral(human)TDLo:140mg/kg NilReported

Oral(rat)LD50:8000mg/kg

Inhalation(rat)LD50:4250mg/m³

Oral(None)None:ratLOAEL66mg/kg/day

■Fordibutylphthalate(DBP):

Instudiesonrats,DBPisabsorbedthroughtheskin,althoughininvitrostudieshumanskinhasbeenfound

tobelesspermeablethanratskintothiscompound.StudiesinlaboratoryanimalsindicatethatDBPis

rapidlyabsorbedfromthegastrointestinaltract,distributedprimarilytotheliverandkidneysofratsand

excretedinurineasmetabolitesfollowingoralorintravenousadministration.Followinginhalation,itwas

consistentlydetectedatlowconcentrationsinthebrain.Availabledataindicatethatinrats,following

ingestion,DBPismetabolisedbynonspecificesterasesmainlyinthesmallintestinetoyieldmono-n-butyl

phthalate(MBP)withlimitedsubsequentbiochemicaloxidationofthealkylsidechainofMBP.MBPisstable

andresistanttohydrolysisofthesecondestergroup.Accumulationhasnotbeenobservedinanyorgan.The

profileofeffectsfollowingexposuretoDBPissimilartothatofotherphthalateesters,which,in

susceptiblespecies,caninducehepatomegaly,increasednumbersofhepaticperoxisomes,foetotoxicity,

teratogenicityandtesticulardamage.

Acutetoxicity:TheacutetoxicityofDBPinratsandmiceislow.Signsofacutetoxicityinlaboratory

animalsincludedepressionofactivity,labouredbreathingandlackofcoordination.Inacaseofaccidental

poisoningofaworkerwhoingestedapproximately10gramsofDBP,recoverywasgradualwithintwoweeksand

completeafter1month.

Onthebasisoflimitedavailabledatainanimalspecies,DBPappearstohavelittlepotentialtoirritate

skinoreyesortoinducesensitization.Inhumans,afewcasesofsensitizationafterexposuretoDBPhave

beenreported,althoughthiswasnotconfirmedincontrolledstudiesoflargernumbersofindividuals

reportedonlyinsecondaryaccounts

Repeatdosetoxicity:Inshort-termrepeated-dosetoxicitystudies,effectsatlowestlevelsinratsafter

oraladministrationfor5to21daysincludedperoxisomeproliferationandhepatomegalyatdosesof420mg/kg

continued...

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Section 11 - TOXICOLOGICAL INFORMATION

bodyweightperdayormore.Inlonger-termstudies,theeffectsinratsobservedfollowingingestionofDBP

forperiodsupto7monthsincludedreducedrateofweightgainatdosesof250mg/kgbodyweightperdayor

more.Increaseinrelativeliverweighthasbeenobservedatdosesof120mg/kgbodyweightormore.

Peroxisomalproliferationwithincreasedperoxisomalenzymeactivityhasbeenobservedatdosesof279mg/kg

bodyweightperdayormore.NecrotichepaticchangesinWistarratshavebeenreportedatdosesof250mg/kg

bodyweightperdayormorebutnotinF-344orSprague-Dawleyratsexposedtoupto2500mg/kgbodyweight

perday.Alterationintesticularenzymesanddegenerationoftesticulargerminalcellsofratshavebeen

observedatdosesof250and571mg/kgbodyweightperday.Thereareconsiderablespeciesdifferencesin

effectsonthetestesfollowingexposuretoDBP,minimaleffectsbeingobservedinmiceandhamstersatdoses

ashighas2000mg/kgbodyweightperday.Inmice,effectsonbodyandorganweightsandhistological

alterationsintheliverindicativeofmetabolicstresshavebeenreportedinarecentsubchronicbioassay,

forwhichtheno-observed-effect-level(NOEL)was353mg/kgbodyweightperday.

Developmentaltoxicity:.Inacontinuousbreedingprotocol,whichincludedcross-overmatingandoffspring

assessmentphases,ratswereexposedto0,1000,5000or10000mgDBP/kginthediet(equivalentto0,66,

320and651mg/kgbodyweightperday).Inthefirstgenerationthereductioninpupweightinthemid-dose

group,intheabsenceofanyadverseeffectonmaternalweight,couldberegardedasadevelopmentaltoxicity

effect.Therewasalsoasignificantreductionoflivelitternumbersatallthreedoselevels.Theeffects

inthesecondgenerationweremoresevere,withreducedpupweightinallgroupsincludingthelow-dosegroup,

structuraldefects(suchasprepucial/penilemalformations,seminiferoustubuledegeneration,andabsenceor

underdevelopmentoftheepididymides)inthemid-andhigh-dosegroups,andsevereeffectsonspermatogenesis

inthehigh-dosegroupthatwerenotseenintheparentanimals.Theseresultssuggestthattheadverse

effectsofDBParemoremarkedinanimalsexposedduringdevelopmentandmaturationthaninanimalsexposed

asadultsonly.NoclearNOELwasestablishedinthisstudy.Thelowest-observed-adverse-effect-level

(LOAEL)wasconsideredtobe66mg/kgbodyweightperday.TheavailablestudiesshowthatDBPgenerally

inducesfoetotoxiceffectsintheabsenceofmaternaltoxicity.AvailabledataalsoindicatethatDBPis

teratogenicathighdosesandthatsusceptibilitytoteratogenesisvarieswithdevelopmentalstageandperiod

ofadministration.Inmice,DBPcauseddose-dependentincreasesinthenumberofresorptionsanddeadfetuses

atoraldosesof400mg/kgbodyweightperdayormore.Dose-dependentdecreasesinfetalweightsandnumber

ofviablelitterswerealsoobservedinmiceatthesedoses.AdequatecarcinogenesisbioassaysforDBPhave

notbeenconducted.TheweightoftheavailableevidenceindicatesthatDBPisnotgenotoxic.

Thematerialmayproduceperoxisomeproliferation.Peroxisomesaresingle,membranelimitedorganellesinthe

cytoplasmthatarefoundinthecellsofanimals,plants,fungi,andprotozoa.Proxisomeproliferators

includecertainhypolipidaemicdrugs,phthalateesterplasticisers,industrialsolvents,herbicides,food

flavours,leukotrieneD4antagonistsandhormones.Animalstudieshaveshownthatperoxisomeproliferators

clearlycausecancer,especiallyoftheliver.

TransitionalPhthalateEsters:producedfromalcoholswithstraight-chaincarbonbackbonesofC4toC6.This

subcategoryalsoincludesaphthalateproducedfrombenzylalcoholasoneestergroupwiththesecondester

composedofanalkylgroupwithaC5carbonbackboneandbutyrategroup.Phthalateesterscontaining>10%C4

toC6moleculeswereconservativelyincludedinthissubcategory.BranchedC7andC8isomers(di-iso-heptyl,

di-iso-octylanddiethylhexylphthalates)incontrasttolineardihexylanddioctylphthalatearemembersof

thisfamily.

Transitionalphthalateshavevarieduses,butarelargelyusedasplasticisersforPVC.Physicochemical

propertiesalsovaryinthatthelowermolecularweighttransitionalphthalatesaremorewater-solublethan

highermolecularweighttransitionalphthalates,butnonewouldbecharacterisedashighlywatersoluble.

Transitionalphthalateshavelowerwatersolubilitythanthelowmolecularweightphthalatesandexceptfor

butylbenzylphthalate(BBP),existingdatasuggesttheydonotexhibitacuteorchronicaquatictoxicity.

Whatdistinguishessomeofthetransitionalphthalatesfromothersistheirgreatermammaliantoxicity

potential,particularlywithregardtoreproductiveanddevelopmentaleffects,comparedtoeitherthelowor

highmolecularweightphthalatesubcategories

AcuteToxicity.TheavailabledataonphthalatesspanningthecarbonrangefromC4toC6indicatethat

phthalateestersinthetransitionalsubcategoryareminimallytoxicbyacuteoralanddermaladministration.

TheoralLD50valueforBBPexceeds2g/kg,andformaterialswithhighermolecularweights,theLD50values

exceedthemaximumamountswhichcanbeadministeredtotheanimalsinamannerconsistentwiththe

principlesofresponsibleanimaluse.

Onememberofthissubcategory,diethylhexylphthalate(DEHP),hasbeentestedforacuteinhalationtoxicity.

continued...

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Section 11 - TOXICOLOGICAL INFORMATION

Itdidnotcauseaneffectatthehighestconcentrationtested.Further,consideringthelowvolatilityof

thesesubstances,inhalationexposureattoxicologicallysignificantlevelsisnotanticipated.

RepeatedDoseToxicity.SeveralsubstancesintheC4toC6range,includingBBP,havebeentestedfor

repeateddosetoxicityinstudiesrangingfrom3weeksto2years.Theprincipaleffectsfoundinthese

studieswerethoseassociatedwithperoxisomeproliferationincludingliverenlargementandinductionof

peroxisomalenzymes.Asshowninacomparativestudyoflivereffects,thestrongestinducersofperoxisome

proliferationarediisononylphthalate(DINP)anddi-iso-decylphthalate(DIDP)withsubstancesofshorter

chainlength(e.g.,BBP)showingmuchlesspronouncedeffects.Thusitisreasonabletoconcludethatother

membersofthissubcategorywouldshoweffectssimilartoBBPandlesspronouncedthanDINPorDIDP.It

shouldalsobenotedthattherelevanceofthesefindingstohumanhealthis,atbest,questionable.Ithas

beenshownthattheseeffectsaremediatedthroughtheperoxisomeproliferation-activatedreceptoralpha

(PPARa)andthatlevelsofPPARaaremuchhigherinrodentsthantheyareinhumans.Thusonewouldexpect

humanstobesubstantiallylessresponsivethanrodentstoperoxisomeproliferatingagents.Empirical

evidencethatthisistrueisprovidedbystudiesinprimatesinwhichrepeatedadministrationofDINPhadno

effectsonliver,kidneyortesticularparameters.

Severalofthesubstancesinthetransitionalphthalateesterssubcategory,however,havebeenshownto

producetesticularatrophywhengiventojuvenileratsathighlevels.Testicularatrophyhasbeenassociated

withBBPandothersubstanceswithC4toC6linearcarbonchains.However,moleculeswithfewerthan4or

morethan6carbonsdidnotproducetesticularatrophyinthesestudies.Althoughtherelevanceofthesedata

areuncertain,asthetestesisnotatargetorganfordiethylhexylphthalate(DEHP)inprimates, thesedata

doprovideoneofthedistinguishingtoxicologicalcharacteristicsofthissubcategoryandareoneofthe

underlyingreasonssupportingthedifferentiationofphthalateestersonthebasisoflengthofthelinear

regionofthecarbon chain.

GeneticToxicity(Salmonella).Anumberofthesubstancesinthissubcategoryincludingthereference

substanceBBPhasbeenassessedintheSalmonellaandmouselymphomaassays.Allofthesesubstanceswere

inactiveintheseassays.

ChromosomalAberrations.BBPanddihexylphthalate(DHP)wereinactiveinmicronucleusassaysinmice.DEHP

wasinactiveinacytogeneticsassayinratbonemarrow.DiisoheptylphthalatewasinactiveinCHOcells,in

vitro..

Reproductivetoxicity: Aseriesofstudiesassessedthestructure-activityrelationshipoftheeffectsof

phthalateestersonfertilityusingacontinuousbreedingprotocol.Thetestsubstancesincludedinthese

studieswerediethyl-,dipropyl-,dibutyl-,dipentyl-,d-n-hexyl-,di-2(ethylhexyl)-,anddi-n-octyl

phthalates.Themostprofoundeffectswereonfertility(i.e.,numberoffemalesdelivering/numbermated)

andnumberoflivebirths.ThesubstanceshowingthegreatestactivitywasDEHPwhichproducedeffectsat

dietarylevelsof0.1%withanoeffectlevelof0.01%.Thenextmostactivecompoundsweredi-n-hexyl-and

di-n-pentylphthalatewhichshowedeffectsintherangeof0.3to0.5%;noeffectlevelswerenot

experimentallydefined.Dipropylphthalatehadaneffectonlivebirthindexat2.5%butproducednoeffects

at1.25%.Diethylphthalateanddi-n-octylphthalatewereinactiveatthehighestlevelstested,2.5%and

5.0%,respectively.Thesedatademonstratedthatmoleculeswithlinearalkylchainsof4to6carbons

profoundlyaffectfertilityinrodents,withDEHPbeingthemostactive.Moleculeswithlongerorshorter

sidechainsareessentiallyinactiveintheseassays.Thesedatawerealsoabasisfortheseparationof

phthalatesintothreecategoriesbasedonlengthofsidechain.

InadditiontothesedatatherearereproductivetoxicitystudiesonBBPandDEHP.

A2-generationreproductivestudywasconductedinratsinwhichBBPwasadministeredviathediet.Parental

effectswerelimitedtochangesinbodyweight,weightgain,andincreasedabsoluteandrelativeliver

weights.IntheF1parents,treatmentwithBBPaffectedmatingandfertilityindicesandspermnumberand

motility.TheF1maleoffspringexhibitedshortenedanogenitaldistance,delayedacquisitionofpubertyand

retentionofnipplesandareolaeaswellasreproductiveeffects.TheNOAELofthestudywasreportedtobe

3750mg/kgforreproductiveeffects.However,formaleF1andF2offspring,theNOELforreproductive

effectswasreportedtobe50mg/kgbasedonreductionsinanogenitaldistance.Thesestudiesalongwith

previousdataprovideagoodbasistoassessthereproductiveeffectsofC4toC6phthalateesters.Although

severalsubstances(diheptyl,heptylnonyl,heptylundecyl)haveestersidechainconstituentsthat

predominatelyfallinthehighmolecularweightsubcategory,thesesubstancesareconservativelyassumedto

exhibitreproductiveeffectssimilartoothertransitionalphthalates.

Developmentaltoxicity:TherehavebeenextensivestudiesofthedevelopmentaltoxicityofBBPandDEHP.

continued...

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NC317TCP Version No:2.0

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Section 11 - TOXICOLOGICAL INFORMATION

Thesesubstancesproducestructuralmalformationsandalsoaffectmalereproductivedevelopment.Noeffect

levelsareintherangeof50to300mg/kgbw/day.Thereisalsoanunpublisheddevelopmentaltoxicity

studyofdi-isoheptylphthalate(DIHP).Theresultsofthesestudiesarebroadlyconsistentwiththe

structure-activityrelationshipspreviouslydescribed,i.e.,thatphthalateesterswithlinearcarbonchains

ofC4toC6carbonsproducemuchmoreprofoundeffectsthateithershorterorlongermolecules.

Phthalateesterswith>10%C4toC6isomerswereconservativelyplacedinthetransitionalsubcategory.This

conclusionissupportedbydevelopmentaltestdataon"711P*"(whichshowedstructuralmalformationsinrats

at1000mg/kg/ daywithaNOAELof200mg/kg/day."711P" isanequalcompositionmixtureofsix

phthalateestersconsistingoflinearandmethyl-branchedC7,C9,andC11estersidechains.Thistest

substanceisconsideredbyEPAunderthefollowingCASNumbers.:68515-44-6(diC7),68515-45-7(diC9),3648-

20-2(diC1I),111381-89-6(C7,C9),111381-90-9(C7,C11),and111381-91-0(C9,C11).Theoverallcontent

ofC4toC6isomersin"711P"isapproximately10%,basedonthecontributionfrommethyl-branchedC7

isomerse.g.,diC7(30%C4-C6);C7,C9(15%C4-C6);andC7,C11(15%C4-C6).Testdataon711Pwereused

selectivelyasread-acrossdatatotheC7-containingsubstancesinthemixture,basedontheC4toC6content

ofeachsubstanceinthemixture.

DIMETHYLETHER:

TOXICITY IRRITATION

Inhalation(rat)LC50:308000mg/m³ NilReported

Section 12 - ECOLOGICAL INFORMATION

Refertodataforingredients,whichfollows:

ETHANOL:

ACETONE:

PROPYLENEGLYCOLMONOMETHYLETHER-ALPHAISOMER:

DIBUTYLPHTHALATE:

DIMETHYLETHER:

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

■DONOTdischargeintosewerorwaterways.

DIBUTYLPHTHALATE:

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

■DoNOTallowproducttocomeincontactwithsurfacewatersortointertidalareasbelowthemeanhigh

watermark.Donotcontaminatewaterwhencleaningequipmentordisposingofequipmentwash-waters.

Wastesresultingfromuseoftheproductmustbedisposedofonsiteoratapprovedwastesites.

DIMETHYLETHER:

ETHANOL:

■Whenethanolisreleasedintothesoilitreadilyandquicklybiodegradesbutmayleachintogroundwater;

mostislostbyevaporation.Whenreleasedintowaterthematerialreadilyevaporatesandisbiodegradable.

Ethanoldoesnotbioaccumulatetoanappreciableextent.

Thematerialisreadilydegradedbyreactionwithphotochemicallyproducedhydroxyradicals;releaseintoair

willresultinphotodegradationandwetdeposition.

EnvironmentalFate:

TERRESTRIALFATE:AnestimatedKocvalueof1indicatesthatethanolisexpectedtohaveveryhighmobility

insoil.Volatilisationofethanolfrommoistsoilsurfacesisexpectedtobeanimportantfateprocessgiven

aHenry'sLawconstantof5X10-6atm-m3/mole.Thepotentialforvolatilisationofethanolfromdrysoil

surfacesmayexistbaseduponanextrapolatedvaporpressureof59.3mmHg.Biodegradationisexpectedtobe

animportantfateprocessforethanolbasedonhalf-livesontheorderofafewdaysforethanolinsandy

soil/groundwatermicrocosms.

continued...

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Chemwatch Material Safety Data Sheet

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NC317TCP Version No:2.0

CD 2010/3 Page 25 of 34

Section 12 - ECOLOGICAL INFORMATION

AQUATICFATE:AnestimatedKocvalueof1indicatesthatethanolisnotexpectedtoadsorbtosuspended

solidsandsediment.VolatilisationfromwatersurfacesisexpectedbaseduponaHenry'sLawconstantof5X10-

6atm-m3/mole.UsingthisHenry'sLawconstantandanestimationmethod,volatilisationhalf-livesfora

modelriverandmodellakeare3and39days,respectively.AnestimatedBCF=3,fromalogKowof-0.31

suggestsbioconcentrationinaquaticorganismsislow.Hydrolysisandphotolysisinsunlitsurfacewatersis

notexpectedtobeanimportantenvironmentalfateprocessforethanolsincethiscompoundlacksfunctional

groupsthathydrolyseorabsorblightunderenvironmentallyrelevantconditions.Ethanolwasdegradedwith

half-livesontheorderofafewdaysinaquaticstudiesconductedusingmicrocosmsconstructedwithalow

organicsandysoilandgroundwater,indicatingitisunlikelytobepersistentinaquaticenvironments(8).

ATMOSPHERICFATE:Ethanol,whichhasanextrapolatedvaporpressureof59.3mmHgat25degC,isexpectedto

existsolelyasavaporintheambientatmosphere.Vapour-phaseethanolisdegradedintheatmosphereby

reactionwithphotochemically-producedhydroxylradicals;thehalf-lifeforthisreactioninairisestimated

tobe5days,calculatedfromitsrateconstantof3.3X10-12m3/molecule-secat25degC.

Ecotoxicity:

logKow:-0.31--0.32

Half-life(hr)air:144

Half-life(hr)H2Osurfacewater:144

Henry'satmm3/mol:6.29E-06

BOD5ifunstated:0.93-1.67,63%

COD:1.99-2.11,97%

ThOD:2.1.

DY-MARKLEADERSTOCKMARKERLEADFREECOLOURSAEROSOL:

■Harmfultoaquaticorganisms,maycauselong-termadverseeffectsintheaquaticenvironment.

ETHANOL:

■FishLC50(96hr.)(mg/l): 13480

■AlgaeIC50(72hr.)(mg/l): 1450

■logKow(Sangster1997): -0.3

■BOD5: 63%

■ThOD: 2.1

■Half-lifeSoil-High(hours): 24

■Half-lifeSoil-Low(hours): 2.6

■Half-lifeAir-High(hours): 122

■Half-lifeAir-Low(hours): 12.2

■Half-lifeSurfacewater-High(hours): 26

■Half-lifeSurfacewater-Low(hours): 6.5

■Half-lifeGroundwater-High(hours): 52

■Half-lifeGroundwater-Low(hours): 13

■Aqueousbiodegradation-Aerobic-High(hours): 26

■Aqueousbiodegradation-Aerobic-Low(hours): 6.5

■Aqueousbiodegradation-Anaerobic-High(hours): 104

■Aqueousbiodegradation-Anaerobic-Low(hours): 26

■Aqueousbiodegradation-Removalsecondarytreatment-High(hours): 67%

■Photooxidationhalf-lifewater-High(hours): 3.20E+05

■Photooxidationhalf-lifewater-Low(hours): 8020

■Photooxidationhalf-lifeair-High(hours): 122

■Photooxidationhalf-lifeair-Low(hours): 12.2

ACETONE:

■FishLC50(96hr.)(mg/l): 8300-40000

■DaphniamagnaEC50(48hr.)(mg/l): 10

■logKow(Prager1995): -0.24

■logKow(Sangster1997): -0.24

■logPow(Verschueren1983): -0.24

continued...

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Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 26 of 34

Section 12 - ECOLOGICAL INFORMATION

■BOD5: 122%

■ThOD: 72

■Half-lifeSoil-High(hours): 168

■Half-lifeSoil-Low(hours): 24

■Half-lifeAir-High(hours): 2790

■Half-lifeAir-Low(hours): 279

■Half-lifeSurfacewater-High(hours): 168

■Half-lifeSurfacewater-Low(hours): 24

■Half-lifeGroundwater-High(hours): 336

■Half-lifeGroundwater-Low(hours): 48

■Aqueousbiodegradation-Aerobic-High(hours): 168

■Aqueousbiodegradation-Aerobic-Low(hours): 24

■Aqueousbiodegradation-Anaerobic-High(hours): 672

■Aqueousbiodegradation-Anaerobic-Low(hours): 96

■Aqueousbiodegradation-Removalsecondarytreatment-High(hours): 75%

■Aqueousbiodegradation-Removalsecondarytreatment-Low(hours): 54%

■Aqueousphotolysishalf-life-High(hours): 270

■Photooxidationhalf-lifewater-High(hours): 3.97E+06

■Photooxidationhalf-lifewater-Low(hours): 9.92E+04

■Photooxidationhalf-lifeair-High(hours): 2790

■Photooxidationhalf-lifeair-Low(hours): 279

■Forketones:

Ketones,unlesstheyarealpha,beta--unsaturatedketones,canbeconsideredasnarcosisorbaselinetoxicity

compounds

Hydrolysismayalsoinvolvetheadditionofwatertoketonestoyieldketalsundermildacidconditions.

However,thisadditionofwateristhermodynamicallyfavorableonlyforlowmolecularweightketones.This

additionisanequilibriumreactionthatisreversibleuponachangeofwaterconcentrationandthereaction

ultimatelyleadstonopermanentchangeinthestructureoftheketonesubstrateThehighermolecularweight

ketonesdonoformstableketals.Therefore,theketonesarestabletowaterunderambientenvironmental

conditions

Anotherpossiblereactionofketonesinwaterinvolvestheenolichydrogenonthecarbonsbondedtothe

carbonylfunction.UnderconditionsofhighpH(pHgreaterthan10),theenolicprotonisabstractedbybase

(OH-)formingacarbanionintermediatethatmayreactwithotherorganicsubstrates(e.g.,ketones,esters,

aldehydes)containingacenterfornucleophilicattack.Thereactions,commonlyrecognizedascondensation

reactions,producehighermolecularweightproducts.Underambientconditionsoftemperature,pH,andlow

concentration,thesecondensationreactionsareunfavorable.

Basedonitsreactionsinair,itseemslikelythatketonesundergophotolysisinwater.Itisprobablethat

ketoneswillbebiodegradedtoanappreciabledegreebymicro-organismsinsoilandwater.Theyareunlikely

tobioconcentrateorbiomagnify.

■foracetone:

logKow:-0.24

Half-life(hr)air:312-1896

Half-life(hr)H2Osurfacewater:20

Henry'satmm3/mol:3.67E-05

BOD5:0.31-1.76,46-55%

COD:1.12-2.07

ThOD:2.2

BCF:0.69

Environmentalfate:

Acetonepreferentiallylocatesintheaircompartmentwhenreleasedtotheenvironment.Asubstantialamount

ofacetonecanalsobefoundinwater,whichisconsistentwiththehighwatertoairpartitioncoefficient

anditssmall,butdetectable,presenceinrainwater,seawater,andlakewatersamples.Verylittleacetone

isexpectedtoresideinsoil,biota,orsuspendedsolids.Thisisentirelyconsistentwiththephysicaland

chemicalpropertiesofacetoneandwithmeasurementsshowingalowpropensityforsoilabsorptionandahigh

continued...

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NC317TCP Version No:2.0

CD 2010/3 Page 27 of 34

Section 12 - ECOLOGICAL INFORMATION

preferenceformovingthroughthesoilandintothegroundwater

Inair,acetoneislostbyphotolysisandreactionwithphotochemicallyproducedhydroxylradicals;the

estimatedhalf-lifeofthesecombinedprocessesisabout22days.Therelativelylonghalf-lifeallows

acetonetobetransportedlongdistancesfromitsemissionsource.

Acetoneishighlysolubleandslightlypersistentinwater,withahalf-lifeofabout20hours;itis

minimallytoxictoaquaticlife.

Acetonereleasedtosoilvolatilisesalthoughsomemayleachintothegroundwhereitrapidlybiodegrades.

Acetonedoesnotconcentrateinthefoodchain.

AcetonemeetstheOECDdefinitionofreadilybiodegradablewhichrequiresthatthebiologicaloxygendemand

(BOD)isatleast70%ofthetheoreticaloxygendemand(THOD)withinthe28-daytestperiod

DrinkingWaterStandard:noneavailable.

SoilGuidelines:noneavailable.

AirQualityStandards:noneavailable.

Ecotoxicity:

Testingshowsthatacetoneexhibitsaloworderoftoxicity

FishLC50:brooktrout6070mg/l;fatheadminnow15000mg/l

BirdLC0(5day):Japanesequail,ring-neckpheasant40,000mg/l

DaphniamagnaLC50(48h):15800mg/l;NOEC8500mg/l

Aquaticinvertebrate2100-16700mg/l

AquaticplantNOEC:5400-7500mg/l

DaphniamagnachronicNOEC1660mg/l

Acetonevaporswereshowntoberelativelytoxictotwotypesinsectsandtheireggs.Thetimeto50%

lethality(LT50)wasfoundtobe51.2hrand67.9hrwhentheflourbeetle(Triboliumconfusum)andtheflour

moth(Ephestiakuehniella)wereexposedtoanairborneacetoneconcentrationof61.5mg/m3.TheLT50values

fortheeggswere30-50%lowerthanfortheadult.Thedirectapplicationofacetoneliquidtothebodyof

theinsectsorsurfaceoftheeggsdidnot,however,causeanymortality.

Theabilityofacetonetoinhibitcellmultiplicationhasbeenexaminedinawidevarietyofmicroorganisms.

TheresultshavegenerallyindicatedmildtominimaltoxicitywithNOECsgreaterthan1700mg/Lforexposures

lastingfrom6hrto4days.Longerexposureperiodsof7to8dayswithbacteriaproducedmixedresults;but

overallthedataindicatealowdegreeoftoxicityforacetone.Theonlyexceptiontothesefindingswerethe

resultsobtainedwiththeflagellatedprotozoa(Entosiphonsulcatum)whichyieldeda3-dayNOECof28mg/L.

PROPYLENEGLYCOLMONOMETHYLETHER-ALPHAISOMER:

■Forglycolethers:

Environmentalfate:

Ethergroupsaregenerallystabletohydrolysisinwaterunderneutralconditionsandambienttemperatures.

OECDguidelinestudiesindicatereadybiodegradabilityforseveralglycolethersalthoughhighermolecular

weightspeciesseemtobiodegradeataslowerrate.Noglycolethersthathavebeentesteddemonstratemarked

resistancetobiodegradativeprocesses.Uponreleasetotheatmospherebyevaporation,highboilingglycol

ethersareestimatedtoundergophotodegradation(atmospherichalflives=2.4-2.5hr).Whenreleasedto

water,glycolethersundergobiodegradation(typically47-92%after8-21days)andhavealowpotentialfor

bioaccumulation(logKowrangesfrom-1.73to+0.51).

Ecotoxicity:

Aquatictoxicitydataindicatethatthetri-andtetraethyleneglycolethersare"practicallynon-toxic"to

aquaticspecies.Nomajordifferencesareobservedintheorderoftoxicitygoingfromthemethyl-tothe

butylethers.

Glycolsexertahighoxygendemandfordecompositionandoncereleasedtotheenvironmentscausethedeathof

aquaticorganismsifdissolvedoxygenisdepleted.

■forpropyleneglycolethers:

Environmentalfate:

Mostareliquidsatroomtemperatureandallarewater-soluble.

Typicalpropyleneglycolethersincludepropyleneglycoln-butylether(PnB);dipropyleneglycoln-butyl

ether(DPnB);dipropyleneglycolmethyletheracetate(DPMA);tripropyleneglycolmethylether(TPM)

Environmentalfate:Logoctanol-waterpartitioncoefficients(logKow's)rangefrom0.309forTPMto1.523

forDPnB.CalculatedBCFsrangefrom1.47forDPnBto3.16forDPMAandTPM,indicatinglowbioaccumulation.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 28 of 34

Section 12 - ECOLOGICAL INFORMATION

Henry'sLawConstants,whichindicatepropensitytopartitionfromwatertoair,arelowforallcategory

members,rangingfrom5.7x10-9atm-m3/moleforTPMto2.7x10-9atm-m3/moleforPnB.Fugacitymodeling

indicatesthatmostpropyleneglycolethersarelikelytopartitionroughlyequallyintothesoilandwater

compartmentsintheenvironmentwithsmalltonegligibleamountsremaininginotherenvironmental

compartments(air,sediment,andaquaticbiota).Propyleneglycolethersareunlikelytopersistinthe

environment.Onceinair,thehalf-lifeofthecategorymembersduetodirectreactionswithphotochemically

generatedhydroxylradicals,rangefrom2.0hoursforTPMto4.6hoursforPnB.Inwater,most membersof

thisfamily are"readilybiodegradable"underaerobicconditions.(DPMAdegradedwithin28days(andwithin

thespecified10-daywindow)butonlyusingpre-adaptedor"acclimated"inoculum.).Insoil,biodegradation

israpidforPMandPMA.

Ecotoxicity:

Acuteaquatictoxicitytestingindicateslowtoxicityforbothethersandacetates.Forethers,effect

concentrationsare>500mg/L.Foracetates,effectconcentrationsare>151mg/L.

logKow:-0.53

Dissolvesrapidlyinwater;thematerialisvolatileandwillpartitiontotheaircompartment.

Readilybiodegradable.

Degradationbyactivatedsludgein29days=90%

Notexpectedtobioaccumulate

FishLC50(96h):fatheadminnow>2000mg/l

DIBUTYLPHTHALATE:

MarinePollutant: Yes

■HazardousAirPollutant: Yes

■AlgaeIC50(72hr.)(mg/l): 10-50(24h

■logKow(Sangster1997): 4.72

■Half-lifeSoil-High(hours): 552

■Half-lifeSoil-Low(hours): 48

■Half-lifeAir-High(hours): 74

■Half-lifeAir-Low(hours): 7.4

■Half-lifeSurfacewater-High(hours): 336

■Half-lifeSurfacewater-Low(hours): 24

■Half-lifeGroundwater-High(hours): 552

■Half-lifeGroundwater-Low(hours): 48

■Aqueousbiodegradation-Aerobic-High(hours): 552

■Aqueousbiodegradation-Aerobic-Low(hours): 24

■Aqueousbiodegradation-Anaerobic-High(hours): 552

■Aqueousbiodegradation-Anaerobic-Low(hours): 48

■Aqueousbiodegradation-Removalsecondarytreatment-High(hours): 95%

■Aqueousbiodegradation-Removalsecondarytreatment-Low(hours): 35%

■Photolysismaximumlightabsorption-High(nano-m): 274

■Photolysismaximumlightabsorption-Low(nano-m): 224.5

■Aqueousphotolysishalf-life-Low(hours): 3466

■Photooxidationhalf-lifewater-High(hours): 1.10E+06

■Photooxidationhalf-lifewater-Low(hours): 2.10E+04

■Photooxidationhalf-lifeair-High(hours): 74

■Photooxidationhalf-lifeair-Low(hours): 7.4

■Firstorderhydrolysishalf-life(hours): 10

■Onthebasisofavailableevidenceconcerningeithertoxicity,persistence,potentialtoaccumulateandor

observedenvironmentalfateandbehaviour,thematerialmaypresentadanger,immediateorlong-termand/or

delayed,tothestructureand/orfunctioningofnaturalecosystems.

■Verytoxictoaquaticorganisms,maycauselong-termadverseeffectsintheaquaticenvironment.

■Fortransitionalphthalateesters:

Ecotoxicity:

Thelowermolecularweighttransitionalphthalate,butylbenzylphthalateBBP,ismorewatersolublethanthe

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

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Section 12 - ECOLOGICAL INFORMATION

remaininghighermolecularweighttransitionalphthalates(dihexylandhigher)andcausesacuteandchronic

aquatictoxicitybelow1mg/L.Thereisanapparentcut-offinacutetoxicityatdihexylphthalateandhigher;

theseresultsarefurtherconfirmedwithQSARmodeling.Bothcalculatedandmeasuredvaluesforenvironmental

toxicityendpointspredictnoeffectsatthelimitofwatersolubilityfordihexylphthalateandhigher.The

dataforthehighermolecularweighttransitionalphthalatestogetherwithread-acrossdataprovide

sufficienttestdatatosuggestthatthesephthalateshavenoassociatedacuteorchronicaquatictoxicity.

Thiscut-offinacutetoxicityisduetotheconcentrationcausingacutetoxicitybeinghigherthanthewater

solubilityofthephthalateester.

Thesamesituationexistsforthosephthalateswhicharemorenon-polar(highercarbonnumber)thandihexyl

phthalate.Thisisconfirmedbyalackofacutetoxicitytofish,invertebrates,oralgaefordiheptyl

phthalate(DHP),di-iso-heptylphthalate(DIHP).Thesamesituationexistsforthosephthalateswhichare

morenon-polar(highercarbonnumber)thandihexylphthalate.Thisisconfirmedbyalackofacutetoxicity

tofish,invertebrates,oralgaeforDHP,DIHP,

Thebettersolubilityandthusthehigheravailabilityofthephthalateswithshortalkylchainsleadstoa

highertoxicity.Concurrentlytheyareavailablefordegradingmicroorganismsandthereforenotpersistent.

Thecompoundswithhighermolecularweightandalowsolubilityarestronglyadsorbedtosoilandto

suspendedparticulatematterinwater.Thereforetheyarenotveryaccessibletobiochemicalprocesses

leadingtodegradation.

■fordibutylphthalate(DBP):

logKow :4.72

:160-6400

Half-life(hr)air :18

Half-life(hr)H2Osurfacewater :1824

Henry'satmm3/mol:4.60E-07

BOD5ifunstated:0.43

ThOD:2.24

BCF:5000

logBCF :1.07-1.5

Environmentalfate:

DBPisrelativelynon-persistentinairandsurfacewaters,andhasahalf-lifeinthesecompartmentsofonly

afewdays.CompletebiodegradationofDBPisrapidunderaerobicconditionsbutmuchslowerunderanaerobic

conditions.Forsoil,similarhalf-livestoairandwaterhavebeenpredicted;however,somestudiessuggest

thatDBPmaybemorepersistentinsoil.DBPwouldbeexpectedtobioaccumulateasaresultofitshigh

octanol-waterpartitioncoefficient.However,itisquitereadilymetabolisedinfishand,consequently,

bioconcentrationfactorstendtobelowerthenpredicted.Thehighestbioconcentrationfactor,basedonthe

parentcompound(DBP),is590forthefatheadminnow.Biomagnificationisunlikelyinterrestrialanimals,

baseduponlimiteddataonbirdsandtherapidmetabolismandexcretionobservedinlaboratorymammals.

Ecotoxicity:

Fish-SalmogairdneriLC50(96h):1.6mg/L.

DaphniaMagnaEC50(48h):3.4mg/L.

Algae-SelenastrumcapricornutumEC50(96h):0.75mg/L.

Phytotoxicity:VapoursofDBPatlowconcentrationscancauseseriousdamagetoplants

InformationontheecotoxicityofDBPincludesacuteandchronicdataforanumberofspeciesfromvarious

trophiclevelsintheaquaticenvironment.Forfreshwateralgaethelowestreported96-hEC50was750ug

DBP/litre.Thelowestreportedvaluesinacutetoxicitytestsonaquaticinvertebrateswerea96-hLC50of

750ug/litre(mysidshrimp)anda48-hEC50of760ug/litre(midgelarvae).Inchronicstudies,themost

sensitiveinvertebratespecieswasDaphniamagna,witha21-dayNOEC(parentsurvival)of500ug/litre.Ina

non-standardtestwiththescud(Gammaruspulex)a10-dayLOECof500ug/litreandaNOECof100ug/litre,

bothbasedonreducedlocomotoractivity,werereported.

Inacutetoxicitytestswithfishthelowestreported96-hLC50forafreshwaterspecieswas350ug/litre

(yellowperch)andforamarinespecies600ug/litre(sheepsheadminnow).Themostsensitivechronicstudy

wasbasedontherainbowtroutwitha99-dayNOEC(growth)of100ug/litreanda99-dayLOECof190ug/litre

(growthreducedbyabout27%).

TheacutetoxicityofDBPtobirdsislow.

TherisktoaquaticorganismsassociatedwiththepresentmeanconcentrationsofDBPinsurfacewaterislow.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 30 of 34

Section 12 - ECOLOGICAL INFORMATION

However,inhighlypollutedriversthesafetymarginismuchsmaller.Thereisinadequatedatatoassessthe

riskofDBPtosediment-dwellingorganisms.Atcurrentlevelsofexposure,itcanbeconcludedthattherisk

tofish-eatingbirdsandmammalsislow.

■forphthalateesters:

Environmentalfate;

Underaerobicandanaerobicconditions,studiesrevealthatmanyphthalateestersaredegradedbyawide

rangeofbacteriaandactinomycetes.Standardizedaerobicbiodegradationtestswithsewagesludgeinocula

showthatwithin28daysapproximately50%ultimatedegradationoccurs.Biodegradationis,therefore,

expectedtobethedominantpathwayinsurfacesoilsandsediments.Intheatmosphere,photodegradationvia

freeradicalattackistheanticipateddominantpathway.Thehalf-lifeofmanyphthalateestersisca.1day

intheair,from<1dayto2weeksinsurfaceandmarinewaters,andfrom<1weektoseveralmonthsin

soils.

Phthalatesarehighmolecularweightchemicals,andarenotexpectedtopartitionsignificantlytoair.

Howeverfortheminoramountthatmaypartitiontoair,modelledpredictionsindicatethattheywouldbe

rapidlyoxidised:witha predictedatmosphericoxidationhalf-lifeofaround0.52days.Theyareexpected

toreactappreciablywithotherphotooxidativespeciesintheatmosphere,suchasO3.Therefore,itis

expectedthatreactionswithhydroxylradicalswillbethemostimportantfateprocessintheatmospherefor

phthalates.

Bioaccumulationofphthalateestersintheaquaticandterrestrialfoodchainislimitedbybiotransformation.

Mostphthalateshaveexperimentalbioaccumulationfactor(BCFs)andbioconcentrationfactor(BAFs)below5000

L/kg,astheyarereadilymetabolisedbyfish

Astudyof18commercialphthalateesterswithalkylchainsrangingfromoneto13carbonsfoundaneight

orderofmagnitudeincreaseinoctanol-watercoefficients(Kow)andafourorderofmagnitudedecreasein

vaporpressurewithincreasinglength.ThisincreaseinKowanddecreaseinvaporpressureresultsin

increasedpartitioningofthephthalateesterstosuspendedsolids,soils,sediments,andaerosols

Thephthalateestersaredistributedthroughouttheenvironmentubiquitously.Theyarefoundcomplexedwith

fulvicacidcomponentsofthehumicsubstancesinsoilandmarineandestuarinewaters.Fulvicacidappears

toactasasolubiliserfortheotherwiseinsolubleesterandservestomediateitstransportand

mobilisationinwaterorimmobilisationinsoil.Phthalateestershavebeenfoundinopenoceanenvironments,

indeepseajellyfish,Atlanticherringandinmackerel.Phthalicesterplasticisersareclearlyrecognised

asgeneralcontaminantsofalmosteverysoilandwaterecosystem.Ingeneraltheyhavelowacutetoxicitybut

theweightofevidencesupportingtheircarcinogenicityissubstantial.Othersubtlechroniceffectshave

alsobeenreported.Aslittleas4ug/mlinculturemediumislethaltochickembryoheartcells.This

concentrationissimilartothatreachedinhumanbloodstoredinvinylplasticbagsforaslittleasone

day.Asphthalatesarepresentindrinkingwaterandfood,concernshavebeenraisedabouttheirlongterm

effectsonhumans.

Ecotoxicity:

Somephthalates(notablydi-2-ethylhexylphthalateanddibutylphthalate)maybedetrimentaltothe

reproductionofthewaterflea(Daphniamagna),zebrafishandguppies

Whilephthalatesmayhaveverylowtruewatersolubilities,theypossesstheabilitytoformsuspensions

whichmaycauseadverseeffectsthroughphysicalcontactwithDaphniaatverylowconcentrations.

Availabletoxicityandwatersolubilityinformationsuggestthatthehighmolecularweightphthalates,form

thesesuspensionsandareabletoelicitchronictoxiceffectsatconcentrationsofapproximately0.05mg/L.

Therefore,thesesubstancesareconsideredtohavethepotentialtoharmaquaticorganismsatrelativelylow

concentrations.

DIMETHYLETHER:

■Watersolubility(g/l): 35300

■logKow(Sangster1997): 0.1

logKow:0.1-0.12

Koc:14

Half-life(hr)air:528

Half-life(hr)H2Osurfacewater:2.6-30

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 31 of 34

Section 12 - ECOLOGICAL INFORMATION

Henry'satmm³/mol:9.78E-04

BCF:1.7

Bioaccumulation:notsig

processesAbiotic:RxnOH*

Ecotoxicity

Ingredient Persistence: Persistence:Air Bioaccumulation Mobility

Water/Soil

ethanol LOW MED LOW HIGH

acetone LOW HIGH LOW HIGH

propyleneglycolmonomethyl LOW LOW LOW HIGH

ether-alphaisomer

dibutylphthalate LOW MED LOW MED

dimethylether LOW LOW HIGH

GESAMP/EHS COMPOSITE LIST - GESAMP Hazard Profiles

Name/ EHSTRNA1a A1b A1 A2 B1 B2 C1 C2 C3 D1 D2 D3 E1 E2 E3

CasNo/

RTECSNo

_________ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___

Propylene 195 628 0 NI 0 NR 0 NI 0 1 0 2 3 D 3

glycol 8

monoalkyl

ether/

Legend:

EHS=EHS Number (EHS=GESAMP Working Group on the Evaluation of the Hazards of Harmful Substances Carried by

Ships) NRT=Net Register Tonnage, A1a=Bioaccumulation log Pow, A1b=Bioaccumulation BCF, A1=Bioaccumulation,

A2=Biodegradation, B1=Acuteaquatic toxicity LC/ECIC50 (mg/l), B2=Chronic aquatic toxicity NOEC (mg/l),

C1=Acute mammalian oral toxicity LD50 (mg/kg), C2=Acutemammalian dermal toxicity LD50 (mg/kg), C3=Acute

mammalian inhalation toxicity LC50 (mg/kg), D1=Skin irritation & corrosion, D2=Eye irritation& corrosion,

D3=Long-term health effects, E1=Tainting, E2=Physical effects on wildlife & benthic habitats, E3=Interference

with coastal amenities,

For column A2: R=Readily biodegradable, NR=Not readily biodegradable.

For column D3: C=Carcinogen, M=Mutagenic, R=Reprotoxic, S=Sensitising, A=Aspiration hazard, T=Target organ

systemic toxicity, L=Lunginjury, N=Neurotoxic, I=Immunotoxic.

For column E1: NT=Not tainting (tested), T=Tainting test positive.

For column E2: Fp=Persistent floater, F=Floater, S=Sinking substances.

The numerical scales start from 0 (no hazard), while higher numbers reflect increasing hazard.

(GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships)

Section 13 - DISPOSAL CONSIDERATIONS

DO NOT allow wash water from cleaning or process equipment to enter drains.

It may be necessary to collect all wash water for treatment before disposal.

In all cases disposal to sewer may be subject to local laws and regulations and these should be considered

first.

Where in doubt contact the responsible authority.

Consult State Land Waste Management Authority for disposal.

Discharge contents of damaged aerosol cans at an approved site.

Allow small quantities to evaporate.

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 32 of 34

Section 13 - DISPOSAL CONSIDERATIONS

DO NOT incinerate or puncture aerosol cans.

Bury residues and emptied aerosol cans at an approved site.

Section 14 - TRANSPORTATION INFORMATION

LabelsRequired:FLAMMABLEGAS

HAZCHEM:

(ADG7)

Land Transport UNDG:

Classordivision: 2 Subsidiaryrisk: None

UNNo.: 1950 UNpackinggroup: None

ShippingName:AEROSOLS

Air Transport IATA:

ICAO/IATAClass: 2.1 ICAO/IATASubrisk: None

UN/IDNumber: 1950 PackingGroup: -

Specialprovisions: A145

CargoOnly

PackingInstructions: 203 MaximumQty/Pack: 150kg

PassengerandCargo PassengerandCargo

PackingInstructions: 203 MaximumQty/Pack: 75kg

PassengerandCargoLimitedQuantity PassengerandCargoLimitedQuantity

PackingInstructions: Y203 MaximumQty/Pack: 30kgG

ShippingName:AEROSOLS,FLAMMABLE

Maritime Transport IMDG:

IMDGClass: 2 IMDGSubrisk: SP63

UNNumber: 1950 PackingGroup: None

EMSNumber: F-D,S-U Specialprovisions: 63190277327959

LimitedQuantities: SeeSP277

ShippingName:AEROSOLS

GESAMP hazard profiles for this material can be found in section 12 of the MSDS.

Section 15 - REGULATORY INFORMATION

POISONS SCHEDULE None

REGULATIONS

Regulations for ingredients

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 33 of 34

Section 15 - REGULATORY INFORMATION

ethanol (CAS: 64-17-5) is found on the following regulatory lists;

"Australia Exposure Standards","Australia Hazardous Substances","Australia High Volume Industrial Chemical

List (HVICL)","Australia Illicit Drug Reagents/Essential Chemicals - Category III","Australia Inventory of

Chemical Substances (AICS)","Australia National Pollutant Inventory","Australia Standard for the Uniform

Scheduling of Drugs and Poisons (SUSDP) - Schedule 5","GESAMP/EHS Composite List - GESAMP Hazard Profiles",

"IMO IBC Code Chapter 18: List of products to which the Code does not apply","IMO MARPOL 73/78 (Annex II) -

List of Other Liquid Substances","IMO Provisional Categorization of Liquid Substances - List 2: Pollutant

only mixtures containing at least 99% by weight of components already assessed by IMO","International Agency

for Research on Cancer (IARC) - Agents Reviewed by the IARC Monographs","International Air Transport

Association (IATA) Dangerous Goods Regulations","International Council of Chemical Associations (ICCA) - High

Production Volume List","International Fragrance Association (IFRA) Survey: Transparency List","OECD

Representative List of High Production Volume (HPV) Chemicals"

acetone (CAS: 67-64-1) is found on the following regulatory lists;

"Australia Exposure Standards","Australia Hazardous Substances","Australia High Volume Industrial Chemical

List (HVICL)","Australia Illicit Drug Reagents/Essential Chemicals - Category III","Australia Inventory of

Chemical Substances (AICS)","Australia National Pollutant Inventory","Australia Standard for the Uniform

Scheduling of Drugs and Poisons (SUSDP) - Appendix E (Part 2)","Australia Standard for the Uniform Scheduling

of Drugs and Poisons (SUSDP) - Appendix F (Part 3)","Australia Standard for the Uniform Scheduling of Drugs

and Poisons (SUSDP) - Schedule 5","GESAMP/EHS Composite List - GESAMP Hazard Profiles","IMO IBC Code Chapter

18: List of products to which the Code does not apply","IMO MARPOL 73/78 (Annex II) - List of Other Liquid

Substances","International Fragrance Association (IFRA) Survey: Transparency List","OECD Representative List

of High Production Volume (HPV) Chemicals","United Nations List of Precursors and Chemicals Frequently used

in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances Under International Control - Table

II"

propylene glycol monomethyl ether - alpha isomer (CAS: 107-98-2) is found on the following

regulatory lists;

"Australia Exposure Standards","Australia Hazardous Substances","Australia Inventory of Chemical Substances

(AICS)","IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk","International

Council of Chemical Associations (ICCA) - High Production Volume List","International Fragrance Association

(IFRA) Survey: Transparency List","OECD Representative List of High Production Volume (HPV) Chemicals"

dibutyl phthalate (CAS: 84-74-2) is found on the following regulatory lists;

"Australia - Australian Capital Territory Environment Protection Regulation Ecosystem maintenance - Organic

chemicals - Non-pesticide anthropogenic organics","Australia Exposure Standards","Australia Hazardous

Substances","Australia Inventory of Chemical Substances (AICS)","Australia National Pollutant Inventory",

"GESAMP/EHS Composite List - GESAMP Hazard Profiles","IMO IBC Code Chapter 17: Summary of minimum

requirements","IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk",

"International Chemical Secretariat (ChemSec) REACH SIN* List (*Substitute It Now!) 1.0","OECD Representative

List of High Production Volume (HPV) Chemicals","OSPAR List of Chemicals for Priority Action","OSPAR List of

Substances of Possible Concern"

dimethyl ether (CAS: 115-10-6) is found on the following regulatory lists;

"Australia Exposure Standards","Australia Hazardous Substances","Australia Inventory of Chemical Substances

(AICS)","International Council of Chemical Associations (ICCA) - High Production Volume List","OECD

Representative List of High Production Volume (HPV) Chemicals"

No data for DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL (CW: 22-0916)

continued...

DY-MARK LEADER STOCKMARKER LEAD FREE COLOURS AEROSOL

Hazard Alert Code: EXTREME

Chemwatch Material Safety Data Sheet

Issue Date: 4-Sep-2009 CHEMWATCH 22-0916

NC317TCP Version No:2.0

CD 2010/3 Page 34 of 34

Section 16 - OTHER INFORMATION

REPRODUCTIVE HEALTH GUIDELINES

Ingredient ORG UF Endpoint CRAdeqTLV

ethanol 1880mg/m3 NA NA NA Yes

dibutylphthalate 0.72mg/m3 1000 D NA -

■Theseexposureguidelineshavebeenderivedfromascreeninglevelofriskassessmentandshouldnotbe

construedasunequivocallysafelimits.ORGSrepresentan8-hourtime-weightedaverageunlessspecified

otherwise.

CR=CancerRisk/10000;UF=Uncertaintyfactor:

TLVbelievedtobeadequatetoprotectreproductivehealth:

LOD:Limitofdetection

Toxicendpointshavealsobeenidentifiedas:

D=Developmental;R=Reproductive;TC=Transplacentalcarcinogen

JankovicJ.,DrakeF.:AScreeningMethodforOccupationalReproductive

AmericanIndustrialHygieneAssociationJournal57:641-649(1996).

■Classification of the preparation and its individual components has drawn on official and authoritative

sources as well as independent review by the Chemwatch Classification committee using available literature

references.

A list of reference resources used to assist the committee may be found at:

www.chemwatch.net/references.

■The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors

determine whether the reported Hazards are Risks in the workplace or other settings. Risks may be determined

by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering

controls must be considered.

This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or

criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written

permission from CHEMWATCH. TEL (+61 3) 9572 4700.

Issue Date: 4-Sep-2009

Print Date: 15-Oct-2010

This is the end of the MSDS.

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