Karvezide

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Irbesartan; Hydrochlorothiazide

Available from:

Sanofi-Aventis Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

KARVEZIDE
®

_irbesartan & hydrochlorothiazide_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Karvezide. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
benefits of you taking this medicine
against the risks it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT KARVEZIDE IS
USED FOR
Karvezide is used to lower high
blood pressure, which doctors call
hypertension.
Everyone has blood pressure. This
pressure helps get your blood all
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
There are often no symptoms of high
blood pressure. The only way of
knowing that you have high blood
pressure is to have your blood
pressure checked on a regular basis.
If high blood pressure is not treated it
can lead to serious health problems,
such as stroke, heart disease and
kidney failure.
_HOW KARVEZIDE WORKS_
Karvezide contains irbesartan and
hydrochlorothiazide. Both medicines
reduce blood pressure in different
ways. Irbesartan belongs to a group
of medicines known as angiotensin-II
receptor antagonists. Angiotensin-II
is a substance produced in the body
that causes blood vessels to narrow.
Irbesartan blocks angiotensin-II and
therefore widens your blood vessels,
making it easier for your heart to
pump blood throughout your body.
This helps to lower your blood
pressure.
Hydrochlorothiazide belongs to the
class of medicines known as
diuretics. Diuretics cause an increase
in the volume of urine. They also
help with lowering blood pressure
particularly when combined with
other blood pressu

Summary of Product characteristics

PRODUCT INFORMATION  
May-2013 
Karvezide - irbesartan hydrochlorothiazide 

Property of the sanofi-aventis group - strictly confidential 
karvezide-ccdsv8-piv9-10may13 
1 
PRODUCT INFORMATION 
KARVEZIDE
®

NAME OF MEDICINE 
AUSTRALIAN APPROVED NAME 
Irbesartan/Hydrochlorothiazide 
Irbesartan:  2-butyl-3-[(2'-(1_H_-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,3-diazaspiro[4.4] non-1-en-4-
one 
Hydrochlorothiazide:
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide   
CHEMICAL STRUCTURE 
The chemical structure of irbesartan is:  
The empiric formula is C
25
H
28
N
6
O and the molecular weight, 428.5.   
The CAS registry number for irbesartan is: CAS-138402-11-6. 
The chemical structure of hydrochlorothiazide is: 

The empiric formula is C
7
H
8
ClN
3
O
4
S
2
 and the molecular weight, 297.7.   
N
N
O
(CH
2
)
3
CH
3
N
N
N
N
H
N
N
S
CL
H
H
O
O
S
H
2
N
O
O
PRODUCT INFORMATION  
May-2013 
Karvezide - irbesartan hydrochlorothiazide 

Property of the sanofi-aventis group - strictly confidential 
karvezide-ccdsv8-piv9-10may13 
2 
The CAS registry number for hydrochlorothiazide is: CAS-58-93-5 
DESCRIPTION 
Karvezide  (irbesartan/hydrochlorothiazide)  is  an  oral  antihypertensive  agent  combining  a 
nonpeptide  angiotensin  II  receptor  (AT
1
  subtype)  antagonist,  irbesartan,  and  a  thiazide  diuretic, 
hydrochlorothiazide. 
Irbesartan is a white to off-white crystalline powder.  It is a relatively non-polar compound with a 
partition coefficient (octanol-water) of 10.1 at a pH
of 7.4.  Irbesartan is slightly soluble in alcohol 
and methylene chloride, and practically insoluble in water. 
Hydrochlorothiazide is a white crystalline powder.  It is
slightly soluble in water but freely soluble 
in sodium hydroxide solution. 
Karvezide 150/12.5 tablets contain 150 mg of irbesartan and 12.5 mg of hydrochlorothiazid